A tale on animal models of Parkinson's disease (Q37882583)

24 August 2017

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title

A tale on animal models of Parkinson's disease (English)

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24 August 2017

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2

Serge Przedborski

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24 August 2017

Erwan Bezard

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PubMed ID

21626544

24 August 2017

language of work or name

English

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publication date

1 May 2011

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24 August 2017

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24 August 2017

26

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24 August 2017

993-1002

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24 August 2017

6

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3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists

24 August 2017

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Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system.

21 January 2018

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Adenosine receptor antagonists potentiate dopamine receptor agonist-induced rotational behavior in 6-hydroxydopamine-lesioned rats.

21 January 2018

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Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model

21 January 2018

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Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer

21 January 2018

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Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

21 January 2018

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MPTP primate model of Parkinson's disease: a mechanographic and electromyographic study.

21 January 2018

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Regional brain uptake of 2-deoxyglucose in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the macaque monkey

21 January 2018

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Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice.

21 January 2018

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Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss.

21 January 2018

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Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat

21 January 2018

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Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity.

21 January 2018

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Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra.

21 January 2018

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 January 2018

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Treatment of mice with methamphetamine produces cell loss in the substantia nigra.

21 January 2018

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Isoquinoline neurotoxins in the brain and Parkinson's disease

21 January 2018

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Stereoselective effect of (R)- and (S)-1-methyl-1,2,3,4-tetrahydroisoquinolines on a mouse model of Parkinson's disease

21 January 2018

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Tetrahydroisoquinoline lacks dopaminergic nigrostriatal neurotoxicity in mice

21 January 2018

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Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons

21 January 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

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alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

21 January 2018

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Alpha-synuclein in Lewy bodies

21 January 2018

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Genetic animal models of Parkinson's disease

21 January 2018

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Alpha-synuclein and transgenic mouse models

21 January 2018

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Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.

21 January 2018

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

21 January 2018

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A Drosophila model of Parkinson's disease

21 January 2018

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In vivo alpha-synuclein overexpression in rodents: a useful model of Parkinson's disease?

21 January 2018

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alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

21 January 2018

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Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease

21 January 2018

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Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease

21 January 2018

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Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

21 January 2018

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Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease

21 January 2018

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A MicroRNA feedback circuit in midbrain dopamine neurons

21 January 2018

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Parkinson's disease: mechanisms and models

21 January 2018

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Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein

21 January 2018

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Alpha-synuclein expression in the substantia nigra of MPTP-lesioned non-human primates

21 January 2018

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The functional anatomy of basal ganglia disorders

21 January 2018

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Parallel Organization of Functionally Segregated Circuits Linking Basal Ganglia and Cortex

21 January 2018

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From single extracellular unit recording in experimental and human Parkinsonism to the development of a functional concept of the role played by the basal ganglia in motor control

21 January 2018

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Primate models of movement disorders of basal ganglia origin

21 January 2018

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The functional anatomy of disorders of the basal ganglia

21 January 2018

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Neural mechanisms underlying parkinsonian symptoms based upon regional uptake of 2-deoxyglucose in monkeys exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

21 January 2018

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Neural mechanisms mediating 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-induced parkinsonism in the monkey: relative contributions of the striatopallidal and striatonigral pathways as suggested by 2-deoxyglucose uptake

21 January 2018

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A hypothesis on the pathophysiological mechanisms that underlie levodopa- or dopamine agonist-induced dyskinesia in Parkinson's disease: implications for future strategies in treatment

21 January 2018

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Subcortical changes in the regional uptake of [3H]-2-deoxyglucose in the brain of the monkey during experimental choreiform dyskinesia elicited by injection of a gamma-aminobutyric acid antagonist into the subthalamic nucleus.

21 January 2018

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Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms.

21 January 2018

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Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate

21 January 2018

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Reversal of experimental parkinsonism by lesions of the subthalamic nucleus

21 January 2018

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Alleviation of parkinsonism by antagonism of excitatory amino acid transmission in the medial segment of the globus pallidus in rat and primate

21 January 2018

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The subthalamic nucleus: a possible target for stereotaxic surgery in Parkinson's disease.

21 January 2018

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Reversal of rigidity and improvement in motor performance by subthalamic high-frequency stimulation in MPTP-treated monkeys

21 January 2018

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MPTP induced hemiparkinsonism in monkeys: behavioral, mechanographic, electromyographic and immunohistochemical studies.

21 January 2018

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Attention and executive function deficits in chronic low-dose MPTP-treated non-human primates

21 January 2018

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Chronic exposure to low doses of MPTP. I. Cognitive deficits in motor asymptomatic monkeys.

21 January 2018

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Interaction between nicotinic and dopaminergic therapies on cognition in a chronic Parkinson model

21 January 2018

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Neurochemical plasticity in the enteric nervous system of a primate animal model of experimental Parkinsonism.

21 January 2018

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Nocturnal sleep structure and temperature slope in MPTP treated monkeys.

21 January 2018

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Sleep disorders in Parkinson's disease: the contribution of the MPTP non-human primate model.

21 January 2018

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Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on the regional distribution of brain monoamines in the rhesus monkey.

21 January 2018

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Pathophysiology of levodopa-induced dyskinesia: potential for new therapies

21 January 2018

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Molecular mechanisms of L-DOPA-induced dyskinesia

21 January 2018

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A model of L-DOPA-induced dyskinesia in 6-hydroxydopamine lesioned mice: relation to motor and cellular parameters of nigrostriatal function

21 January 2018

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Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

21 January 2018

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A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine.

21 January 2018

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Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities.

21 January 2018

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

21 January 2018

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Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

21 January 2018

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Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction.

21 January 2018

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Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling

21 January 2018

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Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila.

21 January 2018

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A Drosophila model for LRRK2-linked parkinsonism

21 January 2018

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Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

21 January 2018

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Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein

21 January 2018

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Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice

21 January 2018

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Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1

21 January 2018

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Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice

21 January 2018

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Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MDS.23696

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24 August 2017

1 reference

PubMed ID

21626544