The importance of interfaces in protein drug delivery - why is protein adsorption of interest in pharmaceutical formulations? (Q37873947)

24 August 2017

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title

The importance of interfaces in protein drug delivery - why is protein adsorption of interest in pharmaceutical formulations? (English)

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24 August 2017

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Lene Jorgensen

4

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Natalie Medlicott

object named as

Natalie J Medlicott

series ordinal

3

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author name string

Charlotte Pinholt

series ordinal

1

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PubMed ID

21557707

24 August 2017

Rune Andersen Hartvig

series ordinal

2

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PubMed ID

21557707

24 August 2017

language of work or name

English

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publication date

11 May 2011

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Expert Opinion on Drug Delivery

24 August 2017

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24 August 2017

8

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24 August 2017

7

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24 August 2017

949-964

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Understanding protein adsorption phenomena at solid surfaces.

24 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Adsorption of proteins from solution at the solid-liquid interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

The interaction of proteins with solid surfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Protein adsorption to solid surfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Why proteins prefer interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

My voyage of discovery to proteins in flatland ...and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Thermodynamics, adsorption kinetics and rheology of mixed protein-surfactant interfacial layers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Irreversible inactivation of interleukin 2 in a pump-based delivery environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Structure, Stability, and Activity of Adsorbed Enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Silica nanoparticle size influences the structure and enzymatic activity of adsorbed lysozyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Structure, stability, and activity of myoglobin adsorbed onto phosphate-grafted zirconia nanoparticles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Interpretation of protein adsorption: surface-induced conformational changes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Solid lipid nanoparticles as a drug delivery system for peptides and proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Protein adsorption and excipient effects on kinetic stability of silicone oil emulsions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Surface-enhanced nucleation of insulin amyloid fibrillation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Energy landscapes for adsorption of a protein-like HP chain as a function of native-state stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Adsorption of proteins at the oil/water interface--observation of protein adsorption by interfacial shear stress measurements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Volumetric interpretation of protein adsorption: kinetics of protein-adsorption competition from binary solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Adsorption of poly(ethylene glycol)-modified lysozyme to silica.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Aggregation of lysozyme and of poly(ethylene glycol)-modified lysozyme after adsorption to silica.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Ellipsometric study of the displacement of milk proteins from the oil-water interface by the non-ionic surfactant C(10)E(8).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Adsorption of monoclonal antibodies to glass microparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Probing structural changes of proteins incorporated into water-in-oil emulsions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Protein adsorption and displacement at lipid layers determined by total internal reflection fluorescence (TIRF).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Adsorption behavior of lysozyme and Tween 80 at hydrophilic and hydrophobic silica-water interfaces.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Interaction of ovalbumin with phospholipids Langmuir-Blodgett film.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Reduction of irreversible protein adsorption on solid surfaces by protein engineering for increased stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Droplet surface properties and rheology of concentrated oil in water emulsions stabilized by heat-modified beta-lactoglobulin B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Modulation of the adsorption properties at air-water interfaces of complexes of egg white ovalbumin with pectin by the dielectric constant

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

The adsorbed conformation of globular proteins at the air/water interface.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Film formation and surface gelation of gelatin molecules at the water/air interface.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Adsorption of lysozyme, beta-casein and their layer-by-layer formation on hydrophilic surfaces: Effect of ionic strength

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Interfacial adsorption of insulin conformational changes and reversibility of adsorption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Staining proteins: a simple method to increase the sensitivity of ellipsometric measurements in adsorption studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Volumetric interpretation of protein adsorption: mass and energy balance for albumin adsorption to particulate adsorbents with incrementally increasing hydrophilicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Volumetric interpretation of protein adsorption: Partition coefficients, interphase volumes, and free energies of adsorption to hydrophobic surfaces.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Volumetric interpretation of protein adsorption: capacity scaling with adsorbate molecular weight and adsorbent surface energy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Influence of glycosylation on the adsorption of Thermomyces lanuginosus lipase to hydrophobic and hydrophilic surfaces.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Assembling fibrinogen at air/water and solid/liquid interfaces using Langmuir and Langmuir-Blodgett films.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Adsorption of bovine serum albumin (BSA) onto lecithin studied by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Adsorption of insulin with varying self-association profiles to a solid Teflon surface--influence on protein structure, fibrillation tendency and thermal stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Aggregation of a monoclonal antibody induced by adsorption to stainless steel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Evidence of partial unfolding of proteins at the ice/freeze-concentrate interface by infrared microscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Ice nucleation temperature influences recovery of activity of a model protein after freeze drying.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Nucleation of protein fibrillation by nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Protein Denaturation in Foam.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Effect of environmental factors on the kinetics of insulin fibril formation: elucidation of the molecular mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Mechanism of insulin aggregation and stabilization in agitated aqueous solutions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Adsorption of poly(ethylene glycol)-modified ribonuclease A to a poly(lactide-co-glycolide) surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Competitive protein adsorption--multilayer adsorption and surface induced protein aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Effect of surface concentration on secondary and tertiary conformational changes of lysozyme adsorbed on silica nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Adsorption and function of recombinant factor VIII at solid-water interfaces in the presence of Tween-80.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Heterogeneous nucleation-controlled particulate formation of recombinant human platelet-activating factor acetylhydrolase in pharmaceutical formulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Inhibition of Amyloid β Protein Fibrillation by Polymeric Nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Strategic approaches for overcoming peptide and protein instability within biodegradable nano- and microparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Preparation and characterization of liposomes as therapeutic delivery systems: a review.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Protein instability in poly(lactic-co-glycolic acid) microparticles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Preparation of biodegradable insulin nanocapsules from biocompatible microemulsions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Stable formulations of recombinant human growth hormone and interferon-gamma for microencapsulation in biodegradable microspheres

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

In situ study of insulin aggregation induced by water-organic solvent interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Stabilization of dichloromethane-induced protein denaturation during microencapsulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Biodegradable microspheres as controlled-release tetanus toxoid delivery systems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Role of organic solvents on Pa-hydroxynitrile lyase interfacial activity and stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Preparation and characterization of protein C-loaded PLA nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Preparing polymer-based sustained-release systems without exposing proteins to water-oil or water-air interfaces and cross-linking reagents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Protein adsorption at the oil/water interface: characterization of adsorption kinetics by dynamic interfacial tension measurements

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Adsorbed protein secondary and tertiary structures by circular dichroism and infrared spectroscopy with refractive index matched emulsions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Lipases at interfaces: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Immunogenicity of biopharmaceuticals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Effects of protein aggregates: an immunologic perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Interaction of gold nanoparticles with common human blood proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Poly(ethylene glycol)-modified proteins: implications for poly(lactide-co-glycolide)-based microsphere delivery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Oral insulin delivery using nanoparticles based on microemulsions with different structure-types: optimisation and in vivo evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Histidine residues in the peptide D-Lys(6)-GnRH: potential for copolymerization in polymeric nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Stability of a trivalent recombinant protein vaccine formulation against botulinum neurotoxin during storage in aqueous solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Enzyme-linked immunosorbent assays using immune complexes for the diagnosis of tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Second-generation biopharmaceuticals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Electrostatic and Hydrophobic Effects of Oligopeptide Insertions on Protein Adsorption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

An entropic perspective of protein stability on surfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

21 January 2018

Emerging PEGylated drugs

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Recent trends in stabilising peptides and proteins in pharmaceutical formulation - considerations in the choice of excipients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Adsorption of protein-surfactant complexes at the water/oil interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Interfacial properties of mixed beta-lactoglobulin-SDS layers at the water/air and water/oil interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Dynamics of protein and mixed protein/surfactant adsorption layers at the water/fluid interface.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Adsorption and function of recombinant Factor VIII at the air-water interface in the presence of Tween 80.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Role of a novel excipient poly(ethylene glycol)-b-poly(L-histidine) in retention of physical stability of insulin at aqueous/organic interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Why does PEG 400 co-encapsulation improve NGF stability and release from PLGA biodegradable microspheres?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

The effect of formulation variables on the characteristics of insulin-loaded poly(lactic-co-glycolic acid) microspheres prepared by a single phase oil in oil solvent evaporation method

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Physico-chemical studies of molecular interactions between non-ionic surfactants and bovine serum albumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Surface forces and protein adsorption on dextran- and polyethylene glycol-modified polydimethylsiloxane

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Competitive protein adsorption of albumin and immunoglobulin G from human serum onto polymer surfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Kinetic and thermodynamic control of protein adsorption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Bioinspired interface for nanobiodevices based on phospholipid polymer chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Unfolding and Intermolecular Association in Globular Proteins Adsorbed at Interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Probing insulin’s secondary structure after entrapment into alginate/chitosan nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Differential adsorption of variants of the Thermomyces lanuginosus lipase on a hydrophobic surface suggests a role for local flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Refolding of Adsorbed Bovine α-Lactalbumin during Surfactant Induced Displacement from a Hydrophobic Interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Proteins at interfaces and in emulsions Stability, rheology and interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Competitive protein adsorption as observed by surface plasmon resonance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Adsorption of surfactants and proteins at fluid interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

Poly(alkycyanoacrylate) nanoparticles for enhanced delivery of therapeutics – is there real potential?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2011.577062

10.1517/17425247.2011.577062

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference

PubMed ID

21557707