Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals (Q37873745)

24 August 2017

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title

Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals (English)

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24 August 2017

Meghan A Campbell

1

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Jesper Wengel

object named as

Jesper Wengel

series ordinal

2

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publication date

10 May 2011

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24 August 2017

Chemical Society Reviews

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24 August 2017

40

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24 August 2017

5680-5689

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24 August 2017

12

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Antisense technologies. Improvement through novel chemical modifications

24 August 2017

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Perspectives on chemistry and therapeutic applications of Locked Nucleic Acid (LNA).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

UNA (unlocked nucleic acid): a flexible RNA mimic that allows engineering of nucleic acid duplex stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Unlocked nucleic acid--an RNA modification with broad potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Synthesis of 2′-O,4′-C-methyleneuridine and -cytidine. Novel bicyclic nucleosides having a fixed C3, -endo sugar puckering

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

A simplified and efficient route to 2'-O, 4'-C-methylene-linked bicyclic ribonucleosides (locked nucleic acid).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

The adenine derivative of alpha-L-LNA (alpha-L-ribo configured locked nucleic acid): synthesis and high-affinity hybridization towards DNA, RNA, LNA and alpha-L-LNA complementary sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Synthesis of 2'-amino-LNA: a new strategy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

2'-O,4'-C-ethylene-bridged nucleic acids (ENA): highly nuclease-resistant and thermodynamically stable oligonucleotides for antisense drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Multilabeled pyrene-functionalized 2'-amino-LNA probes for nucleic acid detection in homogeneous fluorescence assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Amino acids attached to 2'-amino-LNA: synthesis and excellent duplex stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Efficient RNase H-directed cleavage of RNA promoted by antisense DNA or 2'F-ANA constructs containing acyclic nucleotide inserts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Synthesis of an unlocked nucleic acid terpyridine monomer and binding of divalent metal ion in nucleic acid duplexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Sequence-dependent thermodynamic parameters for locked nucleic acid (LNA)-DNA duplex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Thermodynamics of DNA-RNA heteroduplex formation: effects of locked nucleic acid nucleotides incorporated into the DNA strand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Contributions of stacking, preorganization, and hydrogen bonding to the thermodynamic stability of duplexes between RNA and 2'-O-methyl RNA with locked nucleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Thermodynamics of RNA duplexes modified with unlocked nucleic acid nucleotides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Duplex formation of the simplified nucleic acid GNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA:RNA hybrids

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

The crystal structure of an 'All Locked' nucleic acid duplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Design of antisense oligonucleotides stabilized by locked nucleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Inhibition of HIV-1 Tat-dependent trans activation by steric block chimeric 2'-O-methyl/LNA oligoribonucleotides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Implications of high-affinity hybridization by locked nucleic acid oligomers for inhibition of human telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Locked nucleic acid oligonucleotides: the next generation of antisense agents?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Down-modulation of survivin expression and inhibition of tumor growth in vivo by EZN-3042, a locked nucleic acid antisense oligonucleotide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

LNA-mediated microRNA silencing in non-human primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

An endogenous TNF-alpha antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Antisense gapmers selectively suppress individual oncogenic p73 splice isoforms and inhibit tumor growth in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Stimulation of ribosomal frameshifting by antisense LNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

A general purpose RNA-cleaving DNA enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

LNAzymes: incorporation of LNA-type monomers into DNAzymes markedly increases RNA cleavage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

RNA cleaving '10-23' DNAzymes with enhanced stability and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

The advantages of being locked. Assessing the cleavage of short and long RNAs by locked nucleic acid-containing 8-17 deoxyribozymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

“Locked onto the target”: increasing the efficiency of antagomirzymes using locked nucleic acid modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Inhibiting gene expression with locked nucleic acids (LNAs) that target chromosomal DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Killing the messenger: short RNAs that silence gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

siRNAs: applications in functional genomics and potential as therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

RNA interference in mammalian cells by chemically-modified RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Design of LNA-modified siRNAs against the highly structured 5' UTR of coxsackievirus B3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Improved silencing properties using small internally segmented interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Filling the gap in LNA antisense oligo gapmers: the effects of unlocked nucleic acid (UNA) and 4'-C-hydroxymethyl-DNA modifications on RNase H recruitment and efficacy of an LNA gapmer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

RNAi-based therapeutics targeting survivin and PLK1 for treatment of bladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Application of locked nucleic acids to improve aptamer in vivo stability and targeting function

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Aptamers as a model for functional evaluation of LNA and 2'-amino LNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Polymerase chain reaction and transcription using locked nucleic acid nucleotide triphosphates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Efficient enzymatic synthesis of LNA-modified DNA duplexes using KOD DNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Synthesis and evaluation of oligodeoxynucleotides containing acyclic nucleosides: Introduction of three novel analogues and a summary

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

LNA (Locked Nucleic Acid): An RNA Mimic Forming Exceedingly Stable LNA:LNA Duplexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

Stopped-flow kinetics of locked nucleic acid (LNA)-oligonucleotide duplex formation: studies of LNA-DNA and DNA-DNA interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

NMR Studies of Fully Modified Locked Nucleic Acid (LNA) Hybrids: Solution Structure of an LNA:RNA Hybrid and Characterization of an LNA:DNA Hybrid

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1CS15048K

21 January 2018

Identifiers

DOI

10.1039/C1CS15048K

1 reference

24 August 2017

1 reference

PubMed ID

21556437