The in vitro MN assay in 2011: origin and fate, biological significance, protocols, high throughput methodologies and toxicological relevance (Q37871420)

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scientific article published on 03 May 2011

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English	The in vitro MN assay in 2011: origin and fate, biological significance, protocols, high throughput methodologies and toxicological relevance	scientific article published on 03 May 2011

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

24 August 2017

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Europe PubMed Central

The in vitro MN assay in 2011: origin and fate, biological significance, protocols, high throughput methodologies and toxicological relevance (English)

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Europe PubMed Central

PubMed publication ID

24 August 2017

Laetitia Gonzalez

5

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Europe PubMed Central

PubMed publication ID

24 August 2017

Micheline Kirsch-Volders

1

object named as

Micheline Kirsch-Volders

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2

object named as

Gina Plas

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Europe PubMed Central

PubMed publication ID

24 August 2017

7

object named as

Ilse Decordier

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Europe PubMed Central

PubMed publication ID

24 August 2017

Azeddine Elhajouji

3

object named as

Azeddine Elhajouji

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Europe PubMed Central

PubMed publication ID

24 August 2017

author name string

Magdalena Lukamowicz

4

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Europe PubMed Central

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24 August 2017

Kim Vande Loock

6

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Europe PubMed Central

PubMed publication ID

24 August 2017

publication date

3 May 2011

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Europe PubMed Central

PubMed publication ID

24 August 2017

Archives of Toxicology

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Europe PubMed Central

PubMed publication ID

24 August 2017

85

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Europe PubMed Central

PubMed publication ID

24 August 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

24 August 2017

873-899

1 reference

Europe PubMed Central

PubMed publication ID

24 August 2017

https://scigraph.springernature.com/pub.10.1007/s00204-011-0691-4

0 references

Biomarkers in population studies: environmental mutagenesis and risk for cancer

1 reference

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In vitro micronucleus scoring by flow cytometry: differential staining of micronuclei versus apoptotic and necrotic chromatin enhances assay reliability

1 reference

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Flow cytometric analysis of micronuclei in mammalian cell cultures: past, present and future

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Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition

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Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

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Carcinogenicity categorization of chemicals-new aspects to be considered in a European perspective.

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HUman MicroNucleus project: international database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes: I. Effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei

1 reference

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Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus project

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An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans.

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In vitro micronucleus assay scored by flow cytometry provides a comprehensive evaluation of cytogenetic damage and cytotoxicity

1 reference

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Interlaboratory evaluation of a flow cytometric, high content in vitro micronucleus assay

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Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose-response relationships

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Aneuploidy: a matter of bad connections.

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ECVAM retrospective validation of in vitro micronucleus test (MNT)

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Elimination of micronucleated cells by apoptosis after treatment with inhibitors of microtubules

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Influence of caspase activity on micronuclei detection: a possible role for caspase-3 in micronucleation

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Survival of aneuploid, micronucleated and/or polyploid cells: crosstalk between ploidy control and apoptosis

1 reference

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21 January 2018

Automated image analysis of cytokinesis-blocked micronuclei: an adapted protocol and a validated scoring procedure for biomonitoring

1 reference

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21 January 2018

Phenotyping for DNA repair capacity

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21 January 2018

Automated image analysis of micronuclei by IMSTAR for biomonitoring

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21 January 2018

Genetic polymorphisms of genes involved in DNA repair and metabolism influence micronucleus frequencies in human peripheral blood lymphocytes

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Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens

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Confounding experimental considerations in nanogenotoxicology

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Manipulation of the oocyte: possible damage to the spindle apparatus.

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Potential thresholds for genotoxic effects by micronucleus scoring

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Cytokinesis-blocked micronucleus assay as a novel biomarker for lung cancer risk.

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Hypermethylation of the AKAP12 promoter is a biomarker of Barrett's-associated esophageal neoplastic progression

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The Genome Health Clinic and Genome Health Nutrigenomics concepts: diagnosis and nutritional treatment of genome and epigenome damage on an individual basis

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Cytokinesis-block micronucleus cytome assay.

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Low intake of calcium, folate, nicotinic acid, vitamin E, retinol, beta-carotene and high intake of pantothenic acid, biotin and riboflavin are significantly associated with increased genome instability--results from a dietary intake and micronucleu

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Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults

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The HUman MicroNucleus Project--An international collaborative study on the use of the micronucleus technique for measuring DNA damage in humans

1 reference

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Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN project

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0691-4

21 January 2018

HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-011-0691-4

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Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells

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Three-dimensional organization of micronuclei induced by colchicine in PtK1 cells

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In vivo studies in the mouse to define a threshold for the genotoxicity of EMS and ENU.

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Genotoxicity of engineered nanomaterials: A critical review

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Adaptations of the in vitro MN assay for the genotoxicity assessment of nanomaterials.

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Genotoxicity testing of nanomaterials--conclusions

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Resolution of anaphase bridges in cancer cells

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The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: the HUMN project perspective on current status and knowledge gaps

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Human interphase chromosomes: a review of available molecular cytogenetic technologies.

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Elevated G2 chromosomal radiosensitivity in Irish breast cancer patients: a comparison with other studies

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Micronuclei frequency in peripheral blood lymphocytes of cancer patients: a meta-analysis

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Do dose response thresholds exist for genotoxic alkylating agents?

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Evaluation of different cytotoxic and cytostatic measures for the in vitro micronucleus test (MNVit): summary of results in the collaborative trial

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Inclusion of micronuclei in non-divided mononuclear lymphocytes and necrosis/apoptosis may provide a more comprehensive cytokinesis block micronucleus assay for biomonitoring purposes

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Importance of detecting numerical versus structural chromosome aberrations

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Report from the in vitro micronucleus assay working group

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Indirect mechanisms of genotoxicity

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Micronuclei with multiple copies of the X chromosome: do chromosomes replicate in micronuclei?

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SFTG international collaborative study on in vitro micronucleus test I. General conditions and overall conclusions of the study

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Baseline micronuclei frequency in children: estimates from meta- and pooled analyses.

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What do human micronuclei contain?

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Clastogenic and aneugenic effects of three benzimidazole derivatives in the in vitro micronucleus test using human lymphocytes.

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An automated scoring procedure for the micronucleus test by image analysis.

1 reference

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On the difference of micronucleus frequencies in peripheral blood lymphocytes between breast cancer patients and controls.

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Chromosomal aberrations and in vitro radiosensitivity: intra-individual versus inter-individual variability.

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Flow cytometric detection of micronuclei by combined staining of DNA and membranes

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Live cell imaging of micronucleus formation and development

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Identifiers

10.1007/S00204-011-0691-4

1 reference

Europe PubMed Central

PubMed publication ID

24 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 August 2017

ResearchGate publication ID

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