Raltegravir: the first HIV-1 integrase strand transfer inhibitor in the HIV armamentarium (Q37857334)

24 August 2017

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title

Raltegravir: the first HIV-1 integrase strand transfer inhibitor in the HIV armamentarium (English)

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24 August 2017

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Bach-Yen T Nguyen

1

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Robin D Isaacs

2

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Hedy Teppler

3

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Randi Y Leavitt

4

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Peter Sklar

5

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Marian Iwamoto

6

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Larissa A Wenning

7

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Michael D Miller

8

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Joshua Chen

9

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Ramon Kemp

10

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Wei Xu

11

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Robert A Fromtling

12

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Joseph P Vacca

13

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Steven D Young

14

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Michael Rowley

15

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Michael W Lower

16

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Keith M Gottesdiener

17

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Daria J Hazuda

18

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language of work or name

English

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publication date

1 March 2011

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Annals of the New York Academy of Sciences

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published in

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volume

1222

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24 August 2017

page(s)

83-89

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Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel

24 August 2017

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HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase

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Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes

21 January 2018

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Safety, tolerability, and pharmacokinetics of raltegravir after single and multiple doses in healthy subjects.

21 January 2018

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Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme

21 January 2018

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Lack of a clinically important effect of moderate hepatic insufficiency and severe renal insufficiency on raltegravir pharmacokinetics

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Lack of a pharmacokinetic effect of raltegravir on midazolam: in vitro/in vivo correlation

21 January 2018

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Minimal effects of ritonavir and efavirenz on the pharmacokinetics of raltegravir

21 January 2018

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Atazanavir modestly increases plasma levels of raltegravir in healthy subjects

21 January 2018

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Effect of tipranavir-ritonavir on pharmacokinetics of raltegravir

21 January 2018

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Lack of a significant drug interaction between raltegravir and tenofovir.

21 January 2018

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Minimal pharmacokinetic interaction between the human immunodeficiency virus nonnucleoside reverse transcriptase inhibitor etravirine and the integrase inhibitor raltegravir in healthy subjects

21 January 2018

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Effect of rifampin, a potent inducer of drug-metabolizing enzymes, on the pharmacokinetics of raltegravir

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Raltegravir versus Efavirenz regimens in treatment-naive HIV-1-infected patients: 96-week efficacy, durability, subgroup, safety, and metabolic analyses

21 January 2018

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Long-term efficacy and safety of Raltegravir combined with optimized background therapy in treatment-experienced patients with drug-resistant HIV infection: week 96 results of the BENCHMRK 1 and 2 Phase III trials

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21 January 2018

Identifiers

DOI

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24 August 2017

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