Calpain inhibitors: a survey of compounds reported in the patent and scientific literature (Q37857282)

24 August 2017

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title

Calpain inhibitors: a survey of compounds reported in the patent and scientific literature (English)

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24 August 2017

scientific literature

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Isaac O Donkor

1

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PubMed ID

21434837

24 August 2017

language of work or name

English

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publication date

24 March 2011

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Expert Opinion on Therapeutic Patents

24 August 2017

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24 August 2017

21

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24 August 2017

5

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24 August 2017

601-636

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The therapeutic potential of the calpain family: new aspects.

24 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

The calpains: modular designs and functional diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Expanding members and roles of the calpain superfamily and their genetically modified animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Calpain-mediated regulation of platelet signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Calpastatin levels affect calpain activation and calpain proteolytic activity in APP transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Involvement of calpain activation in neurodegenerative processes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Mechanistic role of calpains in postischemic neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Implication of calpain in neuronal apoptosis. A possible regulation of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Calpain as a therapeutic target in traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Calpain-mediated signaling mechanisms in neuronal injury and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

The role of calpain in diabetes-associated platelet hyperactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Calpains and their multiple roles in diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

The role of calcium-activated protease calpain in experimental retinal pathology

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Calpain activity in retinal degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Regulation of calpain-2 in neurons: implications for synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Calpains and muscular dystrophies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Calpains as potential anti-cancer targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Evidence for calpain-mediated androgen receptor cleavage as a mechanism for androgen independence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

HIV-1 Tat C-terminus is cleaved by calpain 1: implication for Tat-mediated neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Calpain is involved in the HIV replication from the latently infected OM10.1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Human immunodeficiency virus (HIV)-induced neurotoxicity: roles for the NMDA receptor subtypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Calpains: attractive targets for the development of synthetic inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Neuroprotection with delayed calpain inhibition after transient forebrain ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Evaluation of a novel calpain inhibitor as a treatment for cataract

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Calpain inhibition and insulin action in cultured human muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Calpain inhibition: a therapeutic strategy targeting multiple disease states.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Calpain as a potential therapeutic target in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

A Ca(2+) switch aligns the active site of calpain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Structure, activation, and biology of calpain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

A survey of calpain inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Comprehensive behavioral phenotyping of calpastatin-knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Structural determinants of the calpain inhibitory activity of calpastatin peptide B27-WT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: enhancing cell permeability by conjugation with penetratin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

A new cell-permeable calpain inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Poly-arginine-fused calpastatin peptide, a living cell membrane-permeable and specific inhibitor for calpain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Molecular modeling studies of peptide inhibitors highlight the importance of conformational prearrangement for inhibition of calpain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Identification of a novel calpain inhibitor using phage display

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Inhibition of calpain-mediated cell death by a novel peptide inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

VE-cadherin-derived cell-penetrating peptide, pVEC, with carrier functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Cellular uptake of an alpha-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior non-endocytically

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

A novel series of urea-based peptidomimetic calpain inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Synthesis and calpain inhibitory activity of alpha-ketoamides with 2,3-methanoleucine stereoisomers at the P2 position

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Synthesis and calpain inhibitory activity of peptidomimetic compounds with constrained amino acids at the P2 position

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Calpain inhibition by alpha-ketoamide and cyclic hemiacetal inhibitors revealed by X-ray crystallography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Molecular mode of action of a covalently inhibiting peptidomimetic on the human calpain protease core

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Crystal structures of calpain-E64 and -leupeptin inhibitor complexes reveal mobile loops gating the active site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Investigation into the P3 binding domain of m-calpain using photoswitchable diazo- and triazene-dipeptide aldehydes: new anticataract agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Synthesis and evaluation of eight-membered cyclic pseudo-dipeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Molecular modeling, synthesis, and biological evaluation of macrocyclic calpain inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Proteases universally recognize beta strands in their active sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Calpain inhibitor, SJA6017, reduces the rate of formation of selenite cataract in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

The novel calpain inhibitor SJA6017 improves functional outcome after delayed administration in a mouse model of diffuse brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Peptidyl aldehyde inhibitors of calpain incorporating P2-proline mimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Synthesis, calpain inhibitory activity, and cytotoxicity of P2-substituted proline and thiaproline peptidyl aldehydes and peptidyl alpha-ketoamides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Development of calpain-specific inactivators by screening of positional scanning epoxide libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

1,2-Benzothiazine 1,1-dioxide alpha-ketoamide analogues as potent calpain I inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Design, synthesis, molecular modeling studies, and calpain inhibitory activity of novel alpha-ketoamides incorporating polar residues at the P1'-position

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Structural basis for the potent calpain inhibitory activity of peptidyl alpha-ketoacids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Calpain inhibitors, a treatment for Alzheimer's disease: position paper

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Cocrystal Structures of Primed Side-Extending α-Ketoamide Inhibitors Reveal Novel Calpain-Inhibitor Aromatic Interactions #

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Determination of peptide substrate specificity for mu-calpain by a peptide library-based approach: the importance of primed side interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Exploration of peptidyl hydrazones as water-soluble calpain inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Exploration of orally available calpain inhibitors 2: peptidyl hemiacetal derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Exploration of cornea permeable calpain inhibitors as anticataract agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Novel 6-hydroxy-3-morpholinones as cornea permeable calpain inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Exploration of orally available calpain inhibitors: peptidyl alpha-ketoamides containing an amphiphile at P3 site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Amelioration of retinal degeneration and proteolysis in acute ocular hypertensive rats by calpain inhibitor ((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Novel cell-penetrating alpha-keto-amide calpain inhibitors as potential treatment for muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Novel dual inhibitors of calpain and lipid peroxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Calpain inhibitors and antioxidants act synergistically to prevent cell necrosis: effects of the novel dual inhibitors (cysteine protease inhibitor and antioxidant) BN 82204 and its pro-drug BN 82270.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

A novel dual inhibitor of calpains and lipid peroxidation (BN82270) rescues the cochlea from sound trauma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Novel dual inhibitors of calpain and lipid peroxidation with enhanced cellular activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Synthesis and biological evaluation of chromone carboxamides as calpain inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Design and synthesis of 4-quinolinone 2-carboxamides as calpain inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

1,2-Benzothiazine 1,1-dioxide P(2)-P(3) peptide mimetic aldehyde calpain I inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Synthesis and biological evaluation of novel piperidine carboxamide derived calpain inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Discovery of phenyl alanine derived ketoamides carrying benzoyl residues as novel calpain inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Benzoylalanine-derived ketoamides carrying vinylbenzyl amino residues: discovery of potent water-soluble calpain inhibitors with oral bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Reduction of myocardial infarction by calpain inhibitors A-705239 and A-705253 in isolated perfused rabbit hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Studies on aromatic compounds: inhibition of calpain I by biphenyl derivatives and peptide-biphenyl hybrids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Solid-phase combinatorial synthesis of peptide-biphenyl hybrids as calpain inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Synthesis of a reported calpain inhibitor isolated from Streptomyces griseus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Synthesis of a small library of diketopiperazines as potential inhibitors of calpain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

A new epicatechin gallate and calpain inhibitory activity from Orostachys japonicus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Ritonavir inhibition of calcium-activated neutral proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Direct effect of human immunodeficiency virus protease inhibitors on neutrophil function and apoptosis via calpain inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Ritonavir does not inhibit calpain in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Synthesis of a 24-Membered Cyclic Peptide-Biphenyl Hybrid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.568480

Isolation and structure elucidation of two new calpain inhibitors from Streptomyces griseus

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.47.1195

Identifiers

DOI

10.1517/13543776.2011.568480

1 reference

24 August 2017

1 reference

PubMed ID

21434837