Metabolite identification by mass spectrometry: forty years of evolution (Q37857237)

24 August 2017

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title

Metabolite identification by mass spectrometry: forty years of evolution (English)

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metabolite identification

24 August 2017

main subject

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based on heuristic

inferred from title

object named as

metabolite identification

4 February 2023

author name string

Pat Wright

series ordinal

1

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24 August 2017

language of work or name

English

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publication date

24 March 2011

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24 August 2017

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24 August 2017

volume

41

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24 August 2017

issue

8

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24 August 2017

page(s)

670-686

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describes a project that uses

24 August 2017

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Strategies for dealing with metabolite elucidation in drug discovery and development

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Can density functional theory (DFT) be used as an aid to a deeper understanding of tandem mass spectrometric fragmentation pathways?

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Characterization of benzo(a)pyrene metabolites by high performance liquid chromatography-mass spectrometry with a direct liquid introduction interface and using negative chemical ionization

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Liquid chromatograph-mass spectrometer for analysis of nonvolatile samples

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Utilization of DBS Within Drug Discovery: Development of a Serial Microsampling Pharmacokinetic Study in Mice

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Versatile new ion source for the analysis of materials in open air under ambient conditions

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Fourier transform ion cyclotron resonance spectroscopy

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Use of the bromine isotope ratio in HPLC-ICP-MS and HPLC-ESI-MS analysis of a new drug in development.

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Sites of metabolic substitution: investigating metabolite structures utilising ion mobility and molecular modelling

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A new Method of Positive Ray Analysis

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Linear ion traps in mass spectrometry

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Metabolism of 3-chloro-4-fluoroaniline in rat using [14C]-radiolabelling, 19F-NMR spectroscopy, HPLC-MS/MS, HPLC-ICPMS and HPLC-NMR.

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A Simple Liquid Chromatography-Tandem Mass Spectrometry Method to Determine Relative Plasma Exposures of Drug Metabolites across Species for Metabolite Safety Assessments

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Accelerator mass spectrometry in pharmaceutical research and development--a new ultrasensitive analytical method for isotope measurement

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Uniformity of ionization response of structurally diverse analytes using a chip-based nanoelectrospray ionization source

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Inductively coupled argon plasma as an ion source for mass spectrometric determination of trace elements

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The Orbitrap: a new mass spectrometer

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On the evaporation of small ions from charged droplets

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Sensitive sulphur-specific detection of omeprazole metabolites in rat urine by high-performance liquid chromatography/inductively coupled plasma mass spectrometry

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Influence of the wavelength in high-irradiance ultraviolet laser desorption mass spectrometry of organic molecules

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Comparison of electrospray, atmospheric pressure chemical ionization, and atmospheric pressure photoionization in the identification of apomorphine, dobutamine, and entacapone phase II metabolites in biological samples

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Can the pharmaceutical industry reduce attrition rates?

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Application of mass spectrometry for metabolite identification

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Electrostatic axially harmonic orbital trapping: a high-performance technique of mass analysis

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The use of on-line high-performance liquid chromatography-mass spectrometry for the identification of ranitidine and its metabolites in urine

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Chemical Ionization Mass Spectrometry. I. General Introduction

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Looking back through the MIST: a perspective of evolving strategies and key focus areas for metabolite safety analysis

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Notizen: Ein neues Massenspektrometer ohne Magnetfeld

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Analytical strategies for identifying drug metabolites

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Applications of MALDI-MSI to Pharmaceutical Research

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Liquid chromatography/mass spectrometry methods for distinguishing N-oxides from hydroxylated compounds

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Response normalized liquid chromatography nanospray ionization mass spectrometry

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Comparison of triple quadrupole, hybrid linear ion trap triple quadrupole, time-of-flight and LTQ-Orbitrap mass spectrometers in drug discovery phase metabolite screening and identification in vitro--amitriptyline and verapamil as model compounds

21 January 2018

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Effect of different solution flow rates on analyte ion signals in nano-ESI MS, or: when does ESI turn into nano-ESI?

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Ion sampling effects under conditions of total solvent consumption

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High-performance liquid chromatography/inductively coupled plasma mass spectrometry and tandem mass spectrometry for the detection of carbon-containing compounds

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Mass spectrometry sampling under ambient conditions with desorption electrospray ionization

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High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-of-flight system as a 'first-line' approach for metabolite identification studies

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Fragmentation of N-oxides (deoxygenation) in atmospheric pressure ionization: investigation of the activation process

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Ultra-low flow nanospray for the normalization of conventional liquid chromatography/mass spectrometry through equimolar response: standard-free quantitative estimation of metabolite levels in drug discovery

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A controlled trial of 6-weeks' treatment with a novel inhaled phosphodiesterase type-4 inhibitor in COPD.

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Bioanalytical applications of accelerator mass spectrometry for pharmaceutical research

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Comparison of negative ion electrospray mass spectra measured by seven tandem mass analyzers towards library formation.

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A holistic strategy for characterizing the safety of metabolites through drug discovery and development

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The use of recently described ionisation techniques for the rapid analysis of some common drugs and samples of biological origin

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Desorption electrospray ionization mass spectrometry: Imaging drugs and metabolites in tissues

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Applications of metabolomics in drug discovery and development

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Using density functional theory to rationalise the mass spectral fragmentation of maraviroc and its metabolites

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'All-in-one' analysis for metabolite identification using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry with collision energy switching

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Selected ion fragmentation with a tandem quadrupole mass spectrometer

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An accurate-mass-based spectral-averaging isotope-pattern-filtering algorithm for extraction of drug metabolites possessing a distinct isotope pattern from LC-MS data

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Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data

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Fast atom bombardment of solids (F.A.B.): a new ion source for mass spectrometry

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A Mass Spectrometer for Isotope and Gas Analysis

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High efficiency collision-induced dissociation in an RF-only quadrupole

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10.3109/00498254.2011.564332

21 January 2018

Identifiers

DOI

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24 August 2017

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