Scar wars: mapping the fate of epithelial-mesenchymal-myofibroblast transition (Q37856705)

24 August 2017

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title

Scar wars: mapping the fate of epithelial-mesenchymal-myofibroblast transition (English)

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24 August 2017

Susan E Quaggin

1

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24 August 2017

András Kapus

series ordinal

2

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24 August 2017

language of work or name

English

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publication date

23 March 2011

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24 August 2017

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24 August 2017

80

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24 August 2017

41-50

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24 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/ki.2011.77

24 August 2017

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cites work

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Progression in chronic kidney disease.

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Renal fibrosis: new insights into the pathogenesis and therapeutics

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Cellular and molecular mechanisms of fibrosis

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7 January 2021

TGF-beta in renal injury and disease

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7 January 2021

Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Integrin-mediated transforming growth factor-beta activation, a potential therapeutic target in fibrogenic disorders

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Tissue stiffness, latent TGF-beta1 activation, and mechanical signal transduction: implications for the pathogenesis and treatment of fibrosis.

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Fibroblast activation and myofibroblast generation in obstructive nephropathy

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Renal fibroblasts and myofibroblasts in chronic kidney disease

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Fibrocytes: bringing new insights into mechanisms of inflammation and fibrosis

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Review: Endothelial-myofibroblast transition, a new player in diabetic renal fibrosis.

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Evidence that fibroblasts derive from epithelium during tissue fibrosis

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

New insights into epithelial-mesenchymal transition in kidney fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Identification and characterization of a fibroblast marker: FSP1

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Transformations between epithelium and mesenchyme: normal, pathological, and experimentally induced

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Epithelial-mesenchymal-epithelial cycling in kidney repair

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Epithelial-mesenchymal transition and its implications for fibrosis

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

The role of epithelial-to-mesenchymal transition in renal fibrosis

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

The basics of epithelial-mesenchymal transition

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Epithelial-mesenchymal transitions in development and disease

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Biomarkers for epithelial-mesenchymal transitions

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Pathogenesis of tubulointerstitial fibrosis in chronic allograft dysfunction

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

miR-200b precursor can ameliorate renal tubulointerstitial fibrosis

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Inhibition of integrin-linked kinase blocks podocyte epithelial-mesenchymal transition and ameliorates proteinuria

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Tranilast modulates fibrosis, epithelial-mesenchymal transition and peritubular capillary injury in unilateral ureteral obstruction rats

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

HGF and BMP-7 ameliorate high glucose-induced epithelial-to-mesenchymal transition of peritoneal mesothelium

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Epithelial-mesenchymal interactions in pulmonary fibrosis

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https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Autophagy is a component of epithelial cell fate in obstructive uropathy

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Resolved: EMT produces fibroblasts in the kidney

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

TGF-beta-induced epithelial to mesenchymal transition

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Epithelial-mesenchymal transitions in development and pathologies

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

EMT, the cytoskeleton, and cancer cell invasion

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Cooperation between snail and LEF-1 transcription factors is essential for TGF-beta1-induced epithelial-mesenchymal transition

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Oncostatin M-induced effects on EMT in human proximal tubular cells: differential role of ERK signaling.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

RGC-32 mediates transforming growth factor-beta-induced epithelial-mesenchymal transition in human renal proximal tubular cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

The characterization of alpha5-integrin expression on tubular epithelium during renal injury

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Integrity of cell-cell contacts is a critical regulator of TGF-beta 1-induced epithelial-to-myofibroblast transition: role for beta-catenin

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Snail1 is involved in the renal epithelial-mesenchymal transition.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Snail is required for transforming growth factor-beta-induced epithelial-mesenchymal transition by activating PI3 kinase/Akt signal pathway

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Transient overexpression of TGF-{beta}1 induces epithelial mesenchymal transition in the rodent peritoneum.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Twist relates to tubular epithelial-mesenchymal transition and interstitial fibrogenesis in the obstructed kidney

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Twist: a regulator of epithelial-mesenchymal transition in lung fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Defining the E-cadherin repressor interactome in epithelial-mesenchymal transition: the PMC42 model as a case study

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

The role of the ZEB family of transcription factors in development and disease.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Cell contact-dependent regulation of epithelial-myofibroblast transition via the rho-rho kinase-phospho-myosin pathway.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

MKL1 mediates TGF-beta1-induced alpha-smooth muscle actin expression in human renal epithelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Linking actin dynamics and gene transcription to drive cellular motile functions

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

A proximal activator of transcription in epithelial-mesenchymal transition

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

TGFbeta1 induces epithelial-mesenchymal transition, but not myofibroblast transdifferentiation of human kidney tubular epithelial cells in primary culture.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Disruption of E-cadherin by matrix metalloproteinase directly mediates epithelial-mesenchymal transition downstream of transforming growth factor-beta1 in renal tubular epithelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Cell phenotype-specific down-regulation of Smad3 involves decreased gene activation as well as protein degradation

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Regulation of Smad3 expression in bleomycin-induced pulmonary fibrosis: a negative feedback loop of TGF-beta signaling

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Smaddening complexity: the role of Smad3 in epithelial-myofibroblast transition

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Progressive renal fibrosis in murine polycystic kidney disease: an immunohistochemical observation

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Origin of interstitial fibroblasts in an accelerated model of angiotensin II-induced renal fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Plasmin(ogen) Promotes Renal Interstitial Fibrosis by Promoting Epithelial-to-Mesenchymal Transition: Role of Plasmin-Activated Signals

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Mice lacking the matrix metalloproteinase-9 gene reduce renal interstitial fibrosis in obstructive nephropathy.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Epithelial-to-mesenchymal transition and oxidative stress in chronic allograft nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

HIVAN phenotype: consequence of epithelial mesenchymal transdifferentiation

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Glomerular epithelial-mesenchymal transdifferentiation in pauci-immune crescentic glomerulonephritis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Immunolocalization of fibroblast growth factor-1 (FGF-1), its receptor (FGFR-1), and fibroblast-specific protein-1 (FSP-1) in inflammatory renal disease

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Tubular phenotypic change in progressive tubulointerstitial fibrosis in human glomerulonephritis.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Fibroblast-specific protein 1 is a specific prognostic marker for renal survival in patients with IgAN.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Gremlin: a novel mediator of epithelial mesenchymal transition and fibrosis in chronic allograft nephropathy.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Risk Factors for Early Epithelial to Mesenchymal Transition in Renal Grafts

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Epithelial to mesenchymal transition during late deterioration of human kidney transplants: the role of tubular cells in fibrogenesis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Phenotypic transitions and fibrosis in diabetic nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Mouse in red: red fluorescent protein expression in mouse ES cells, embryos, and adult animals.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Origin of new cells in the adult kidney: results from genetic labeling techniques

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Silencing inhibits Cre-mediated recombination of the Z/AP and Z/EG reporters in adult cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.77

7 January 2021

Identifiers

DOI

10.1038/KI.2011.77

1 reference

Dimensions Publication ID

24 August 2017

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1 reference