Chronic obstructive pulmonary disease and lung cancer: new molecular insights (Q37856648)

24 August 2017

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title

Chronic obstructive pulmonary disease and lung cancer: new molecular insights (English)

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chronic obstructive pulmonary disease

24 August 2017

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1

Ian M Adcock

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24 August 2017

Gaetano Caramori

2

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PubMed ID

21430413

24 August 2017

Peter J Barnes

series ordinal

3

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24 August 2017

24 March 2011

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24 August 2017

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24 August 2017

81

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24 August 2017

265-284

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24 August 2017

4

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Chronic obstructive pulmonary disease in non-smokers

24 August 2017

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Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data

21 January 2018

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Systemic inflammation and mortality in chronic obstructive pulmonary disease

21 January 2018

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The growing burden of chronic obstructive pulmonary disease and lung cancer in women: examining sex differences in cigarette smoke metabolism

21 January 2018

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Epidemiology and global impact of chronic obstructive pulmonary disease

21 January 2018

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Lung cancer and chronic obstructive pulmonary disease: needs and opportunities for integrated research

21 January 2018

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Impaired lung function and lung cancer incidence in a cohort of Swedish construction workers

21 January 2018

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Airways obstruction and the risk for lung cancer

21 January 2018

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COPD prevalence is increased in lung cancer, independent of age, sex and smoking history

21 January 2018

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Relationship between reduced forced expiratory volume in one second and the risk of lung cancer: a systematic review and meta-analysis

21 January 2018

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Epigenetics and environmental lung disease

21 January 2018

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Lung carcinoma in African Americans

21 January 2018

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21 January 2018

Cancer statistics, 2009

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The International Epidemiology of Lung Cancer: geographical distribution and secular trends.

21 January 2018

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Population-based trends in lung cancer incidence in women

21 January 2018

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Nonsmall cell lung cancer in never smokers

21 January 2018

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Current concepts on the role of inflammation in COPD and lung cancer

21 January 2018

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Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship

21 January 2018

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COPD increases the risk of squamous histological subtype in smokers who develop non-small cell lung carcinoma

21 January 2018

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Trends in incidence and prognosis of the histological subtypes of lung cancer in North America, Australia, New Zealand and Europe

21 January 2018

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Lung cancer--time to move on from chemotherapy

21 January 2018

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Global cancer statistics, 2002

21 January 2018

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The nature of small-airway obstruction in chronic obstructive pulmonary disease

21 January 2018

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Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction.

21 January 2018

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Pathophysiology of airflow limitation in chronic obstructive pulmonary disease

21 January 2018

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Medicine. Neutrophils find smoke attractive

21 January 2018

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Immunopathology of the small-airway submucosa in smokers with and without chronic obstructive pulmonary disease.

21 January 2018

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Sputum eosinophilia predicts benefit from prednisone in smokers with chronic obstructive bronchitis

21 January 2018

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Cigarette smoke-induced emphysema: A role for the B cell?

21 January 2018

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Antielastin autoimmunity in tobacco smoking-induced emphysema

21 January 2018

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Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease.

21 January 2018

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Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction

21 January 2018

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Incidence of chronic obstructive pulmonary disease in a cohort of young adults according to the presence of chronic cough and phlegm.

21 January 2018

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Airway epithelial repair, regeneration, and remodeling after injury in chronic obstructive pulmonary disease

21 January 2018

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The relations between structural changes in small airways and pulmonary-function tests

21 January 2018

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Cigarette smoke induces an unfolded protein response in the human lung: a proteomic approach

21 January 2018

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Expression of ErbB receptors and mucins in the airways of long term current smokers.

21 January 2018

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Smoking cessation and bronchial epithelial remodelling in COPD: a cross-sectional study

21 January 2018

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Epidermal growth factor receptor family in lung cancer and premalignancy

21 January 2018

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Molecular damage in the bronchial epithelium of current and former smokers

21 January 2018

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Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis

21 January 2018

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Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium

21 January 2018

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Changes in bronchial epithelium in relation to cigarette smoking, 1955-1960 vs. 1970-1977

21 January 2018

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The field of tissue injury in the lung and airway

21 January 2018

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Genetics of preneoplasia: lessons from lung cancer

21 January 2018

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Computer simulations of particle deposition in the lungs of chronic obstructive pulmonary disease patients

21 January 2018

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Lung cancer and lung stem cells: strange bedfellows?

21 January 2018

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Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion

21 January 2018

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Identification of bronchioalveolar stem cells in normal lung and lung cancer

21 January 2018

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Paving the road for lung stem cell biology: bronchioalveolar stem cells and other putative distal lung stem cells

21 January 2018

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Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis

21 January 2018

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Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease.

21 January 2018

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Gene expression profiling of human lung tissue from smokers with severe emphysema.

21 January 2018

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Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer

21 January 2018

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Comparison of proteomic and transcriptomic profiles in the bronchial airway epithelium of current and never smokers

21 January 2018

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Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression

21 January 2018

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Effects of cigarette smoke on the human airway epithelial cell transcriptome

21 January 2018

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Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers' non-small cell lung carcinomas.

21 January 2018

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A prediction model for lung cancer diagnosis that integrates genomic and clinical features

21 January 2018

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Gene expression profiling of non-small-cell lung cancer

21 January 2018

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A small-cell lung cancer genome with complex signatures of tobacco exposure

21 January 2018

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A comprehensive catalogue of somatic mutations from a human cancer genome

21 January 2018

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Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma.

21 January 2018

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MicroRNA expression differentiates histology and predicts survival of lung cancer

21 January 2018

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A translational view of the molecular pathogenesis of lung cancer

21 January 2018

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Gene-environment interactions in chronic obstructive pulmonary disease

21 January 2018

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Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease.

21 January 2018

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Risk of lung cancer among white and black relatives of individuals with early-onset lung cancer

21 January 2018

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A major lung cancer susceptibility locus maps to chromosome 6q23-25.

21 January 2018

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Familial lung cancer: genetic susceptibility and relationship to chronic obstructive pulmonary disease

21 January 2018

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Polymorphism of selected enzymes involved in detoxification and biotransformation in relation to lung cancer

21 January 2018

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Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression

21 January 2018

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Xenobiotic-metabolizing enzymes in human lung

21 January 2018

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Gene-environment interactions in the development of chronic obstructive pulmonary disease.

21 January 2018

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Genetic polymorphisms of cytochrome p450 and matrix metalloproteinase in chronic obstructive pulmonary disease.

21 January 2018

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Association between polymorphisms of microsomal epoxide hydrolase and COPD: results from meta-analyses

21 January 2018

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Association of susceptibility to the development of lung adenocarcinoma with the heme oxygenase-1 gene promoter polymorphism.

21 January 2018

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Association of COPD candidate genes with computed tomography emphysema and airway phenotypes in severe COPD

21 January 2018

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21 January 2018

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Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

21 January 2018

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Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.

21 January 2018

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Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

21 January 2018

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Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice

21 January 2018

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Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema

21 January 2018

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Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1

21 January 2018

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Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease

21 January 2018

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Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

21 January 2018

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Promoter polymorphisms and transcript levels of nicotinic receptor CHRNA5.

21 January 2018

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A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

21 January 2018

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A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

21 January 2018

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Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer

21 January 2018

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Role of NF-kappaB and DNA repair protein Ku on apoptosis in pancreatic acinar cells

21 January 2018

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Oxidative stress induces nuclear loss of DNA repair proteins Ku70 and Ku80 and apoptosis in pancreatic acinar AR42J cells

21 January 2018

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Acetylcholine-induced proliferation of fibroblasts and myofibroblasts in vitro is inhibited by tiotropium bromide

21 January 2018

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Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells

21 January 2018

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The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans

21 January 2018

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Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals

21 January 2018

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Acquired somatic mutations in the molecular pathogenesis of COPD.

21 January 2018

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Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

21 January 2018

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The DNA-dependent protein kinase: the director at the end.

21 January 2018

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DNA-PK: the means to justify the ends?

21 January 2018

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A means to a DNA end: the many roles of Ku.

21 January 2018

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State of the art. Chronic obstructive pulmonary disease, inflammation, and lung cancer

21 January 2018

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Specific combinations of DNA repair gene variants and increased risk for non-small cell lung cancer.

21 January 2018

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Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: a molecular epidemiologic study

21 January 2018

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DNA demethylation by DNA repair

21 January 2018

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Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

21 January 2018

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p300-mediated acetylation of histone H3 lysine 56 functions in DNA damage response in mammals

21 January 2018

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SIRT1 regulates the function of the Nijmegen breakage syndrome protein

21 January 2018

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Decreased histone deacetylase activity in chronic obstructive pulmonary disease.

21 January 2018

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A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9.

21 January 2018

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SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease.

21 January 2018

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Cigarette smoke triggers code red: p21CIP1/WAF1/SDI1 switches on danger responses in the lung.

21 January 2018

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Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer

21 January 2018

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High-throughput molecular analysis in lung cancer: insights into biology and potential clinical applications

21 January 2018

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DNA methylomes, histone codes and miRNAs: tying it all together

21 January 2018

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Update in lung cancer 2008

21 January 2018

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21 January 2018

Epigenetics in cancer

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The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

21 January 2018

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Epigenetics and airways disease

21 January 2018

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High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer

21 January 2018

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Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis

21 January 2018

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DNA methylation markers and early recurrence in stage I lung cancer

21 January 2018

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Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate.

21 January 2018

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A functional genetic variant in microRNA-196a2 is associated with increased susceptibility of lung cancer in Chinese

21 January 2018

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MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium

21 January 2018

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Reduced miR-146a increases prostaglandin E₂in chronic obstructive pulmonary disease fibroblasts

21 January 2018

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Inflammation and cancer: back to Virchow?

21 January 2018

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Cancer and inflammation: implications for pharmacology and therapeutics

21 January 2018

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Tumor immunoediting and immunosculpting pathways to cancer progression.

21 January 2018

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The CXCR4/SDF-1 chemokine receptor axis: a new target therapeutic for non-small cell lung cancer

21 January 2018

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Lung cancer and inflammation: interaction of chemokines and hnRNPs

21 January 2018

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Cyclophilin A is required for CXCR4-mediated nuclear export of heterogeneous nuclear ribonucleoprotein A2, activation and nuclear translocation of ERK1/2, and chemotactic cell migration

21 January 2018

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Detection of plasma hnRNP B1 mRNA, a new cancer biomarker, in lung cancer patients by quantitative real-time polymerase chain reaction.

21 January 2018

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Association of nonsteroidal anti-inflammatory drugs with lung cancer: results from a large cohort study

21 January 2018

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Regular adult aspirin use decreases the risk of non-small cell lung cancer among women

21 January 2018

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Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung

21 January 2018

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NF-kappaB as a critical link between inflammation and cancer

21 January 2018

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Increased expression of nuclear factor-kappaB in bronchial biopsies from smokers and patients with COPD.

21 January 2018

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Increased staining for phospho-Akt, p65/RELA and cIAP-2 in pre-neoplastic human bronchial biopsies

21 January 2018

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The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer

21 January 2018

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Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation

21 January 2018

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Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

21 January 2018

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Kinase inhibitors and airway inflammation.

21 January 2018

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A role for phosphoinositol 3-kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease.

21 January 2018

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Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease.

21 January 2018

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Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci

21 January 2018

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Airway PI3K pathway activation is an early and reversible event in lung cancer development

21 January 2018

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Proteomic profiling identifies pathways dysregulated in non-small cell lung cancer and an inverse association of AMPK and adhesion pathways with recurrence

21 January 2018

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Mitogen-activated protein kinase activation in lung adenocarcinoma: a comparative study between ever smokers and never smokers

21 January 2018

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Involvement of p38alpha mitogen-activated protein kinase in lung metastasis of tumor cells

21 January 2018

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Cisplatin induces cytotoxicity through the mitogen-activated protein kinase pathways and activating transcription factor 3.

21 January 2018

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p38alpha: a suppressor of cell proliferation and tumorigenesis

21 January 2018

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Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: implications for future therapeutic approaches

21 January 2018

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Activity of the suppressor of cytokine signaling-3 promoter in human non-small-cell lung cancer.

21 January 2018

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Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: a biochemical and genetic study of established cancer cell lines and clinical isolated human cancer cells.

21 January 2018

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Targeting PPAR receptors in the airway for the treatment of inflammatory lung disease

21 January 2018

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Roles of peroxisome proliferator-activated receptor-alpha and -gamma in the development of non-small cell lung cancer

21 January 2018

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Treatment effects of low-dose theophylline combined with an inhaled corticosteroid in COPD.

21 January 2018

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Acetylation of non-histone proteins modulates cellular signalling at multiple levels

21 January 2018

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Nrf2 defends the lung from oxidative stress

21 January 2018

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Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2).

21 January 2018

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Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study.

21 January 2018

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Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease

21 January 2018

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Inhaled corticosteroids and risk of lung cancer among COPD patients who quit smoking.

21 January 2018

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CT detected indeterminate pulmonary nodules in a chemoprevention trial of fluticasone.

21 January 2018

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The influence of fluticasone inhalation on markers of carcinogenesis in bronchial epithelium.

21 January 2018

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A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium.

21 January 2018

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Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease

21 January 2018

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Basic and clinical aspects of non-neuronal acetylcholine: expression of non-neuronal acetylcholine in lung cancer provides a new target for cancer therapy

21 January 2018

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Activated cholinergic signaling provides a target in squamous cell lung carcinoma

21 January 2018

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A 4-year trial of tiotropium in chronic obstructive pulmonary disease

21 January 2018

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The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy

21 January 2018

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Proteasome inhibition sensitizes non-small cell lung cancer to histone deacetylase inhibitor-induced apoptosis through the generation of reactive oxygen species

21 January 2018

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Combined histone deacetylase and NF-kappaB inhibition sensitizes non-small cell lung cancer to cell death

21 January 2018

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Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis

21 January 2018

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Oxidative stress induced lung cancer and COPD: opportunities for epigenetic therapy

21 January 2018

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Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial

21 January 2018

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Animal and human studies with the mitochondria-targeted antioxidant MitoQ.

21 January 2018

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Oxidative stress and redox regulation of lung inflammation in COPD.

21 January 2018

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Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer

21 January 2018

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21 January 2018

Identifiers

DOI

10.1159/000324601

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24 August 2017

1 reference

PubMed ID

21430413