Regulation of the SREBP transcription factors by mTORC1. (Q37856383)

24 August 2017

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title

Regulation of the SREBP transcription factors by mTORC1. (English)

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24 August 2017

Almut Schulze

5

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author name string

Caroline A Lewis

1

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24 August 2017

Beatrice Griffiths

2

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24 August 2017

Claudio R Santos

3

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24 August 2017

Mario Pende

4

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24 August 2017

1 April 2011

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Biochemical Society Transactions

24 August 2017

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24 August 2017

39

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24 August 2017

495-499

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24 August 2017

2

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SREBP in signal transduction: cholesterol metabolism and beyond

24 August 2017

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

AKT/PKB signaling: navigating downstream

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Perturbations of the AKT signaling pathway in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Defining the role of mTOR in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Bidirectional transport of amino acids regulates mTOR and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAkt

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST0390495

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST0390495

The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST0390495

A phosphorylation cascade controls the degradation of active SREBP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Sirolimus modifies cholesterol homeostasis in hepatic cells: a potential molecular mechanism for sirolimus-associated dyslipidemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Rapamycin down-regulates LDL-receptor expression independently of SREBP-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Sterol regulatory element-binding proteins are negatively regulated through SUMO-1 modification independent of the ubiquitin/26 S proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7).

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

New insights into mTOR signaling: mTORC2 and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

mTOR and cancer: many loops in one pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

Genetic ablation of S6-kinase does not prevent processing of SREBP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390495

21 January 2018

Identifiers

DOI

10.1042/BST0390495

1 reference

24 August 2017

1 reference