Tuning heavy metal compounds for anti-tumor activity: is diversity the key to ruthenium's success? (Q37855894)

24 August 2017

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title

Tuning heavy metal compounds for anti-tumor activity: is diversity the key to ruthenium's success? (English)

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24 August 2017

Simon M Page

1

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PubMed ID

21426130

24 August 2017

Sally R Boss

series ordinal

2

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PubMed ID

21426130

24 August 2017

Paul D Barker

series ordinal

3

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24 August 2017

1 June 2009

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Future Medicinal Chemistry

24 August 2017

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24 August 2017

1

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24 August 2017

541-559

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24 August 2017

3

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New trends for metal complexes with anticancer activity

24 August 2017

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INHIBITION OF CELL DIVISION IN ESCHERICHIA COLI BY ELECTROLYSIS PRODUCTS FROM A PLATINUM ELECTRODE

21 January 2018

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Cellular processing of platinum anticancer drugs

21 January 2018

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Cisplatin: mode of cytotoxic action and molecular basis of resistance

21 January 2018

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New metal complexes as potential therapeutics

21 January 2018

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Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance.

21 January 2018

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Oxidation induced by the antioxidant glutathione (GSH).

21 January 2018

1 reference

Synthesis, characterization, and cytotoxicity of a series of estrogen-tethered platinum(IV) complexes

21 January 2018

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Light-activated destruction of cancer cell nuclei by platinum diazide complexes

21 January 2018

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A photoactivated trans-diammine platinum complex as cytotoxic as cisplatin

21 January 2018

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Ruthenium antimetastatic agents

21 January 2018

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The in vivo inhibition of tumor growth by ruthenium red: its relationship with the metabolism of calcium in the tumor

21 January 2018

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Blockade by ruthenium red of tissue factor-initiated coagulation

21 January 2018

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Reduction and subsequent binding of ruthenium ions catalyzed by subcellular components

21 January 2018

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Mutagenic and toxic effects of ruthenium.

21 January 2018

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Pharmacological control of lung metastases of solid tumours by a novel ruthenium complex

21 January 2018

1 reference

A Phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent.

21 January 2018

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KP1019, a new redox-active anticancer agent--preclinical development and results of a clinical phase I study in tumor patients

21 January 2018

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The heterocyclic ruthenium(III) complex KP1019 (FFC14A) causes DNA damage and oxidative stress in colorectal tumor cells.

21 January 2018

1 reference

Anti-tumour activity in non-small cell lung cancer models and toxicity profiles for novel ruthenium(II) based organo-metallic compounds.

21 January 2018

1 reference

Kinetics of aquation and anation of ruthenium(II) arene anticancer complexes, acidity and X-ray structures of aqua adducts.

21 January 2018

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Highly selective binding of organometallic ruthenium ethylenediamine complexes to nucleic acids: novel recognition mechanisms.

21 January 2018

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In vitro and in vivo evaluation of ruthenium(II)-arene PTA complexes

21 January 2018

1 reference

Carbohydrate-metal complexes and their potential as anticancer agents

21 January 2018

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In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands

21 January 2018

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Ruthenium porphyrin compounds for photodynamic therapy of cancer

21 January 2018

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Mixed ligand ruthenium(II) complexes of bis(pyrid-2-yl)-/bis(benzimidazol-2-yl)-dithioether and diimines: study of non-covalent DNA binding and cytotoxicity.

21 January 2018

1 reference

Differences in structure, physiological stability, electrochemistry, cytotoxicity, DNA and protein binding properties between two Ru(III) complexes.

21 January 2018

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Development of organometallic ruthenium-arene anticancer drugs that resist hydrolysis

21 January 2018

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Synthesis, structural characteristics, DNA binding properties and cytotoxicity studies of a series of Ru(III) complexes.

21 January 2018

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Controlling ligand substitution reactions of organometallic complexes: tuning cancer cell cytotoxicity.

21 January 2018

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Structure-activity relationships for cytotoxic ruthenium(II) arene complexes containing N,N-, N,O-, and O,O-chelating ligands.

21 January 2018

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Catalytic organometallic anticancer complexes

21 January 2018

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Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes.

21 January 2018

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The contrasting chemistry and cancer cell cytotoxicity of bipyridine and bipyridinediol ruthenium(II) arene complexes.

21 January 2018

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Metal-based antitumour drugs in the post genomic era.

21 January 2018

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Combined arene ruthenium porphyrins as chemotherapeutics and photosensitizers for cancer therapy

21 January 2018

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Selective cytotoxic Ru(II) arene Cp* complex salts [R-PhRuCp*](+)X(-) for X = BF4(-), PF6(-), and BPh4(-).

21 January 2018

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Distinct effects of dinuclear ruthenium(III) complexes on cell proliferation and on cell cycle regulation in human and murine tumor cell lines

21 January 2018

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Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers

21 January 2018

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Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues

21 January 2018

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Homodinuclear (Pt,Pt) and heterodinuclear (Ru,Pt) metal compounds as DNA-protein cross-linking agents: potential suicide DNA lesions

21 January 2018

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Synthesis, characterization, and in vitro evaluation of a potentially selective anticancer, mixed-metal [ruthenium(III)-platinum(II)] trinuclear complex

21 January 2018

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Identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography Fourier transform ion cyclotron mass spectrometry combined with (18)O-labeling

21 January 2018

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The "complex-in-a-complex" cations [(acac)2M subset Ru6(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+: A trojan horse for cancer cells

21 January 2018

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Rapid access to unexplored chemical space by ligand scanning around a ruthenium center: discovery of potent and selective protein kinase inhibitors

21 January 2018

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Exploring biologically relevant chemical space with metal complexes

21 January 2018

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Structure-Based Design of an Organoruthenium Phosphatidyl-inositol-3-kinase Inhibitor Reveals a Switch Governing Lipid Kinase Potency and Selectivity

21 January 2018

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Extremely Tight Binding of a Ruthenium Complex to Glycogen Synthase Kinase 3

21 January 2018

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Dinuclear ruthenium(II) triple-stranded helicates: luminescent supramolecular cylinders that bind and coil DNA and exhibit activity against cancer cell lines

21 January 2018

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Interactions of antitumor metallodrugs with serum proteins: advances in characterization using modern analytical methodology.

21 January 2018

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From bench to bedside--preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A).

21 January 2018

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Application of capillary electrophoresis-inductively coupled plasma mass spectrometry to comparative studying of the reactivity of antitumor ruthenium(III) complexes differing in the nature of counter-ion toward human serum proteins.

21 January 2018

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Capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry: a novel approach for the analysis of anticancer metallodrugs in human serum and plasma

21 January 2018

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The maximal affinity of ligands

21 January 2018

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Proteomic approaches in understanding action mechanisms of metal-based anticancer drugs

21 January 2018

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Characterisation of cisplatin binding sites in human serum proteins using hyphenated multidimensional liquid chromatography and ESI tandem mass spectrometry

21 January 2018

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X-ray structure and designed evolution of an artificial transfer hydrogenase

21 January 2018

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Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide

21 January 2018

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Carbon monoxide: a putative neural messenger

21 January 2018

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NPAS2: a gas-responsive transcription factor

21 January 2018

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CO-metal interaction: Vital signaling from a lethal gas

21 January 2018

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Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB

21 January 2018

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Iron homeostasis: recently identified proteins provide insight into novel control mechanisms

21 January 2018

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Inhibition of Topoisomerase II Catalytic Activity by Two Ruthenium Compounds: A Ligand-Dependent Mode of Action†

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/FMC.09.25

1 reference

24 August 2017

1 reference

PubMed ID

21426130