Targeting transcription factor Stat5a/b as a therapeutic strategy for prostate cancer. (Q37854477)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21416055%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

review article

1 reference

title

Targeting transcription factor Stat5a/b as a therapeutic strategy for prostate cancer (English)

1 reference

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25 January 2020

author name string

Zhiyong Liao

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21416055%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Marja T Nevalainen

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21416055%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

language of work or name

English

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publication date

21 November 2010

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American Journal of Translational Research

25 January 2020

published in

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25 January 2020

volume

3

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25 January 2020

issue

2

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25 January 2020

page(s)

133-138

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Local prolactin is a target to prevent expansion of basal/stem cells in prostate tumors

25 January 2020

cites work

1 reference

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Transcription factor Stat3 stimulates metastatic behavior of human prostate cancer cells in vivo, whereas Stat5b has a preferential role in the promotion of prostate cancer cell viability and tumor growth.

6 September 2017

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Discovery and development of therapeutic aptamers.

6 September 2017

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Therapeutic potential of JAK2 inhibitors

6 September 2017

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The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors

6 September 2017

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Prospect of JAK2 inhibitor therapy in myeloproliferative neoplasms

6 September 2017

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A Rac GTPase-activating protein, MgcRacGAP, is a nuclear localizing signal-containing nuclear chaperone in the activation of STAT transcription factors

6 September 2017

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Signal transducer and activator of transcription 5A/B in prostate and breast cancers

6 September 2017

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Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B

6 September 2017

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Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo

6 September 2017

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Discovery of chromone-based inhibitors of the transcription factor STAT5.

6 September 2017

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Stat5 as a diagnostic marker for leukemia

6 September 2017

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JAK2 inhibitor therapy in myeloproliferative disorders: rationale, preclinical studies and ongoing clinical trials

6 September 2017

1 reference

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Tracking STAT nuclear traffic

6 September 2017

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Targeting the STAT pathway in head and neck cancer: recent advances and future prospects.

6 September 2017

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Getting the message across, STAT! Design principles of a molecular signaling circuit.

6 September 2017

1 reference

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The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells

6 September 2017

1 reference

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The STATs of cancer--new molecular targets come of age

6 September 2017

1 reference

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Serine phosphorylation of STATs

6 September 2017

1 reference

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DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056559

Three-dimensional structure of the Stat3beta homodimer bound to DNA

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056559

Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056559

Prolactin and prolactin receptors are expressed and functioning in human prostate

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056559

Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056559

Growth hormone activation of Stat 1, Stat 3, and Stat 5 in rat liver. Differential kinetics of hormone desensitization and growth hormone stimulation of both tyrosine phosphorylation and serine/threonine phosphorylation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056559

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056559

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056559

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056559

Autocrine prolactin promotes prostate cancer cell growth via Janus kinase-2-signal transducer and activator of transcription-5a/b signaling pathway

6 September 2017

1 reference

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Inhibition of transcription factor Stat5 induces cell death of human prostate cancer cells

14 September 2017

1 reference

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Role of serine phosphorylation of Stat5a in prolactin-stimulated beta-casein gene expression.

14 September 2017

1 reference

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A molecular mimic of phosphorylated prolactin markedly reduced tumor incidence and size when DU145 human prostate cancer cells were grown in nude mice.

28 September 2017

1 reference

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Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription

28 September 2017

1 reference

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Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity

28 September 2017

1 reference

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Hormone regulation of human prostate in organ culture

28 September 2017

1 reference

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Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo.

23 June 2018

1 reference

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Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser725 of Stat5a and Ser730 of Stat5b in prolactin-sensitive cells.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056559

A Single Amino Acid in the DNA Binding Regions of STAT5A and STAT5B Confers Distinct DNA Binding Specificities

1 September 2018

1 reference

12 December 2020

Human prolactin (hPRL) antagonists inhibit hPRL-activated signaling pathways involved in breast cancer cell proliferation

1 reference

12 December 2020

Activation of signal transducer and activator of transcription 5 in human prostate cancer is associated with high histological grade

1 reference

12 December 2020

Activation of signal transducer and activator of transcription-5 in prostate cancer predicts early recurrence

1 reference

12 December 2020

Mammary gland-specific nuclear factor is present in lactating rodent and bovine mammary tissue and composed of a single polypeptide of 89 kDa

1 reference

12 December 2020

Transcription factor Stat5 synergizes with androgen receptor in prostate cancer cells

1 reference

12 December 2020

Identifiers

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21416055%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

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