β(3)-Adrenoceptor ligand development history through patent review (Q37853580)

24 August 2017

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title

β(3)-Adrenoceptor ligand development history through patent review (English)

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24 August 2017

Maria Grazia Perrone

1

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Antonio Scilimati

object named as

Antonio Scilimati

series ordinal

2

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language of work or name

English

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publication date

17 March 2011

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Expert Opinion on Therapeutic Patents

24 August 2017

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24 August 2017

21

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24 August 2017

4

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24 August 2017

505-536

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Beta 3 and atypical beta-adrenoceptors

24 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Beta 3-adrenoreceptor regulation of nitric oxide in the cardiovascular system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from beta3-adrenoceptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

In situ assessment of the role of the beta 1-, beta 2- and beta 3-adrenoceptors in the control of lipolysis and nutritive blood flow in human subcutaneous adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

The beta3-adrenoceptor as a therapeutic target: current perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Beta3-adrenergic relaxation of bovine iris sphincter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Beta 3-adrenergic receptors regulate retinal endothelial cell migration and proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Beta 3-adrenoceptor stimulation induces vasorelaxation mediated essentially by endothelium-derived nitric oxide in rat thoracic aorta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Beta 3-adrenoceptor in rat aorta: molecular and biochemical characterization and signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Beta 3-adrenoceptors in the cardiovascular system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Characterization of beta3-adrenoceptors in human internal mammary artery and putative involvement in coronary artery bypass management

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Endothelial beta3-adrenoceptors mediate vasorelaxation of human coronary microarteries through nitric oxide and endothelium-dependent hyperpolarization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Expression of beta 3-adrenoceptor mRNA in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Activation of beta2- and beta3-adrenergic receptors increases brain tryptophan

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

GPR40 is partially required for insulin secretion following activation of beta3-adrenergic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Beta-adrenergic agonists and hypertrophy of skeletal muscles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Stereospecific synthesis and bio-activity of novel beta(3)-adrenoceptor agonists and inverse agonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

beta3-adrenoceptors in the cardiovascular system: putative roles in human pathologies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

β(3) adrenergic stimulation of the cardiac Na+-K+ pump by reversal of an inhibitory oxidative modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Expression and functional role of beta-adrenoceptors in the human urinary bladder urothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Effect of (R)-2-(2-aminothiazol-4-yl)-4'-{2-[(2-hydroxy-2-phenylethyl)amino]ethyl} acetanilide (YM178), a novel selective beta3-adrenoceptor agonist, on bladder function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Beta3-adrenoceptors in urinary bladder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Tissue functions mediated by beta(3)-adrenoceptors-findings and challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

In vitro inhibition of intestinal motility by phenylethanolaminotetralines: evidence of atypical beta-adrenoceptors in rat colon

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Inhibitory effects of SR 58611A on canine colonic motility: evidence for a role of beta 3-adrenoceptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Demonstration of functional neuronal beta3-adrenoceptors within the enteric nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Gastroprotective effect of beta3 adrenoreceptor agonists ZD 7114 and CGP 12177A in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

The beta3-adrenoceptor agonist SR58611A ameliorates experimental colitis in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

The beta3-adrenoceptor agonist GW427353 (Solabegron) decreases excitability of human enteric neurons via release of somatostatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Beta3-adrenoceptor agonists: possible role in the treatment of overactive bladder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

The norepinephrine-driven metastasis development of PC-3 human prostate cancer cells in BALB/c nude mice is inhibited by beta-blockers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Beta3-adrenoceptor is the predominant beta-adrenoceptor subtype in human myometrium and its expression is up-regulated in pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Importance of uterine cell death, renewal, and their hormonal regulation in hamsters that show progesterone-dependent implantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Apoptosis in the placenta of pregnancies complicated with IUGR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

The contribution of preterm birth to infant mortality rates in the United States.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Chorioamnionitis and labor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

A functional genomic study to identify differential gene expression in the preterm and term human myometrium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Cell death: critical control points

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

ADRB3 adrenergic receptor is a key regulator of human myometrial apoptosis and inflammation during chorioamnionitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Role of beta3-adrenoceptors for intrahepatic resistance and portal hypertension in liver cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Stimulation of the beta3-Adrenoceptor as a novel treatment strategy for anxiety and depressive disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Confirmation of antidepressant potential of the selective beta3 adrenoceptor agonist amibegron in an animal model of depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Implication of beta3-adrenoceptors in the antidepressant-like effects of amibegron using Adrb3 knockout mice in the chronic mild stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Beta 3-adrenoceptor agonists as anti-diabetic and anti-obesity drugs in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Human beta3 adrenergic receptor agonists containing cyanoguanidine and nitroethylenediamine moieties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Tryptamine-based human beta3-adrenergic receptor agonists. Part 1: SAR studies of the 7-position of the indole ring

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Relationship between stereochemistry and the beta3-adrenoceptor agonistic activity of 4'-hydroxynorephedrine derivative as an agent for treatment of frequent urination and urinary incontinence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Novel substituted 4-aminomethylpiperidines as potent and selective human beta3-agonists. Part 1: aryloxypropanolaminomethylpiperidines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Stereoselectivity for interactions of agonists and antagonists at mouse, rat and human beta3-adrenoceptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Single-molecule spectroscopy of the beta(2) adrenergic receptor: observation of conformational substates in a membrane protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Binding of agonists, antagonists and inverse agonists to the human delta-opioid receptor produces distinctly different conformational states distinguishable by plasmon-waveguide resonance spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

The selectivity of beta-adrenoceptor agonists at human beta1-, beta2- and beta3-adrenoceptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Pharmacological evidence for the presence of functional beta(3)-adrenoceptors in rat retinal blood vessels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Novel and potent human and rat beta3-adrenergic receptor agonists containing substituted 3-indolylalkylamines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Selectivity and potency of agonists for the three subtypes of cloned human beta-adrenoceptors expressed in Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Substituted oxazole benzenesulfonamides as potent human beta3 adrenergic receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

(4-Piperidin-1-yl)phenyl amides: potent and selective human beta(3) agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

2,4-Thiazolidinediones as potent and selective human beta3 agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

4-Aminopiperidine ureas as potent selective agonists of the human beta(3)-adrenergic receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Heptahelical and other G-protein-coupled receptors (GPCRs) signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Discovery of a novel and potent human and rat beta3-adrenergic receptor agonist, [3-[(2R)-[[(2R)-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1H-indol-7-yloxy]acetic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

Acute effect of L-796568, a novel beta 3-adrenergic receptor agonist, on energy expenditure in obese men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.561316

10.1517/13543776.2011.561316

21 January 2018

Identifiers

DOI

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24 August 2017

1 reference

PubMed ID

21410429