In vitro cell culture models to study the corneal drug absorption (Q37850457)

24 August 2017

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title

In vitro cell culture models to study the corneal drug absorption (English)

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24 August 2017

Stephan Reichl

1

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24 August 2017

Christian Kölln

series ordinal

2

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24 August 2017

Matthias Hahne

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3

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24 August 2017

Jessica Verstraelen

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4

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24 August 2017

language of work or name

English

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publication date

8 March 2011

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Expert Opinion on Drug Metabolism & Toxicology

24 August 2017

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24 August 2017

7

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24 August 2017

5

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24 August 2017

559-578

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Cell culture models of the ocular barriers

24 August 2017

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https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Ultrastructure of the human cornea

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Ocular drug delivery. Pharmacokinetic considerations

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Biopharmaceutical considerations in topical ocular drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

The suprabasal layer of corneal epithelial cells represents the major barrier site to the passive movement of small molecules and trafficking leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Transport processes across the rabbit corneal epithelium: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

The transport barrier of epithelia: a comparative study on membrane permeability and charge selectivity in the rabbit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Synergistic effect of EDTA and boric acid on corneal penetration of CS-088.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Electrophysiological characterization of tight junctional pathway of rabbit cornea treated with ophthalmic ingredients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Ocular toxicity of some corneal penetration enhancers evaluated by electrophysiology measurements on isolated rabbit corneas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Permeability of cornea, sclera, and conjunctiva: a literature analysis for drug delivery to the eye.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Drug transport in corneal epithelium and blood-retina barrier: emerging role of transporters in ocular pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Transporters/receptors in the anterior chamber: pathways to explore ocular drug delivery strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Molecular evidence and functional expression of P-glycoprotein (MDR1) in human and rabbit cornea and corneal epithelial cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Effluxing ABC transporters in human corneal epithelium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Role of metabolism in ocular drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Morphology and DOPA reaction of cultivated corneal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Air-interface condition promotes the formation of tight corneal epithelial cell layers for drug transport studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Beta adrenergic antagonist permeation across cultured rabbit corneal epithelial cells grown on permeable supports.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Cultured rabbit corneal epithelium elicits levofloxacin absorption and secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Transport of timolol and tilisolol in rabbit corneal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Pilocarpine permeability across ocular tissues and cell cultures: influence of formulation parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Tissue distribution of moxaverine-hydrochloride in the rabbit eye and plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Characterization of active ion transport across primary rabbit corneal epithelial cell layers (RCrECL) cultured at an air-interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Ex vivo preservation and expansion of human limbal epithelial stem cells on amniotic membrane cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Cell culture models of the human cornea - a comparative evaluation of their usefulness to determine ocular drug absorption in-vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Identification and characterization of a Na+-dependent neutral amino acid transporter, ASCT1, in rabbit corneal epithelial cell culture and rabbit cornea

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Expression and localization of carnitine/organic cation transporter OCTN1 and OCTN2 in ocular epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Monocarboxylate transport in human corneal epithelium and cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Transport of acebutolol through rabbit corneal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Pharmacokinetics of erythromycin in rabbit corneas after single-dose infusion: role of P-glycoprotein as a barrier to in vivo ocular drug absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Interaction of ocular hypotensive agents (PGF2 alpha analogs-bimatoprost, latanoprost, and travoprost) with MDR efflux pumps on the rabbit cornea

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Enhanced corneal absorption of erythromycin by modulating P-glycoprotein and MRP mediated efflux with corticosteroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Modulation of P-glycoprotein-mediated efflux by prodrug derivatization: an approach involving peptide transporter-mediated influx across rabbit cornea.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Molecular evidence and functional expression of a novel drug efflux pump (ABCC2) in human corneal epithelium and rabbit cornea and its role in ocular drug efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Molecular evidence and functional expression of multidrug resistance associated protein (MRP) in rabbit corneal epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Expression of multidrug resistance associated protein 5 (MRP5) on cornea and its role in drug efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Chloride channels and transporters in human corneal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Development of cultured rabbit corneal epithelium for drug permeation studies: a comparison with excised rabbit cornea.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Effects of different N-trimethyl chitosans on in vitro/in vivo ofloxacin transcorneal permeation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Cyclosporine A loaded SLNs: evaluation of cellular uptake and corneal cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Fluid transport by cultured corneal epithelial cell layers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Permeability characteristics of novel mydriatic agents using an in vitro cell culture model that utilizes SIRC rabbit corneal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Permeability of chemical delivery systems across rabbit corneal (SIRC) cell line and isolated corneas: a comparative study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Transport of acyclovir ester prodrugs through rabbit cornea and SIRC-rabbit corneal epithelial cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Mechanism of L-ascorbic acid uptake by rabbit corneal epithelial cells: evidence for the involvement of sodium-dependent vitamin C transporter 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Carrier mediated uptake of L-tyrosine and its competitive inhibition by model tyrosine linked compounds in a rabbit corneal cell line (SIRC)--strategy for the design of transporter/receptor targeted prodrugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Functional differences in nucleoside and nucleobase transporters expressed on the rabbit corneal epithelial cell line (SIRC) and isolated rabbit cornea

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Identification and functional characterization of a Na+-independent large neutral amino acid transporter, LAT1, in human and rabbit cornea

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Corneal epithelial cell cultures as a tool for research, drug screening and testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Characterization of wound reepithelialization using a new human tissue-engineered corneal wound healing model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Evaluation of a human corneal epithelial cell line as an in vitro model for assessing ocular irritation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

A collaborative evaluation of the cytotoxicity of two surfactants by using the human corneal epithelial cell line and the WST-1 test

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Expression of ABC-transporters in human corneal tissue and the transformed cell line, HCE-T.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Interleukin-1beta-induced disruption of barrier function in cultured human corneal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Upregulation of ZO-1 in cultured human corneal epithelial cells by a peptide (PHSRN) corresponding to the second cell-binding site of fibronectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Up-regulation of ZO-1 expression and barrier function in cultured human corneal epithelial cells by substance P.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Contribution of aldehyde dehydrogenase 3A1 to disulfiram penetration through monolayers consisting of cultured human corneal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Films based on human hair keratin as substrates for cell culture and tissue engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Molecular expression and functional evidence of a drug efflux pump (BCRP) in human corneal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Detection and regulation of cationic amino acid transporters in healthy and diseased ocular surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Ocular pharmacokinetics and hypotensive activity of PF-04475270, an EP4 prostaglandin agonist in preclinical models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Ocular gelling microspheres: in vitro precorneal retention time and drug permeation through reconstituted corneal epithelium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Characterization of human corneal epithelial cell model as a surrogate for corneal permeability assessment: metabolism and transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Epithelial-stromal interactions: Specific stimulation of corneal epithelial cell growth in vitro by a factor(s) from cultured stromal fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Comparison between serum-free and fibroblast-cocultured single-cell clonal culture systems: evidence showing that epithelial anti-apoptotic activity is present in 3T3 fibroblast-conditioned media

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Bovine corneal stroma and epithelium reconstructed in vitro: characterisation and response to surfactants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Reconstructed human cornea produced in vitro by tissue engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Basement membrane assembly and differentiation of cultured corneal cells: importance of culture environment and endothelial cell interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Impact of cell source on human cornea reconstructed by tissue engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Functional human corneal equivalents constructed from cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Development of a hemicornea from human primary cell cultures for pharmacotoxicology testing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Establishing and functional testing of a canine corneal construct

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Reconstruction of an in vitro cornea and its use for drug permeation studies from different formulations containing pilocarpine hydrochloride

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Development of an organotypic corneal construction as an in vitro model for permeability studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

The use of a porcine organotypic cornea construct for permeation studies from formulations containing befunolol hydrochloride

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Immortalization of human corneal endothelial cells using electroporation protocol optimized for human corneal endothelial and human retinal pigment epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Human corneal equivalent as cell culture model for in vitro drug permeation studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Human cornea construct HCC-an alternative for in vitro permeation studies? A comparison with human donor corneas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Esterase activity of human organotypic cornea construct (HCC) as in vitro model for permeation studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Drug release and permeation studies of nanosuspensions based on solidified reverse micellar solutions (SRMS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Diclofenac sodium delivery to the eye: in vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Sustained release and permeation of timolol from surface-modified solid lipid nanoparticles through bioengineered human cornea

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Industrial perspective in ocular drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Species differences in the responses of the eye to irritation and trauma: a hypothesis of divergence in ocular defense mechanisms, and the choice of experimental animals for eye research

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Cell cultures as tools in biopharmacy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Biopharmaceutics classification system: validation and learnings of an in vitro permeability assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Development of an ex vivo method for evaluation of precorneal residence of topical ophthalmic formulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Corneal epithelium as a platform for secretion of transgene products after transfection with liposomal gene eyedrops

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Low molecular weight hyaluronan shielding of DNA/PEI polyplexes facilitates CD44 receptor mediated uptake in human corneal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Bioadhesive hyaluronan-chitosan nanoparticles can transport genes across the ocular mucosa and transfect ocular tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Integration and application of vitrified collagen in multilayered microfluidic devices for corneal microtissue culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Drug transporter and cytochrome P450 mRNA expression in human ocular barriers: implications for ocular drug disposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Mechanism of corneal permeation of L-valyl ester of acyclovir: targeting the oligopeptide transporter on the rabbit cornea

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Novel dipeptide prodrugs of acyclovir for ocular herpes infections: Bioreversion, antiviral activity and transport across rabbit cornea

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Identification of a Na+-dependent cationic and neutral amino acid transporter, B(0,+), in human and rabbit cornea

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

The prostaglandin transporter OATP2A1 is expressed in human ocular tissues and transports the antiglaucoma prostanoid latanoprost

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Sequence analysis and homology modeling suggest that primary congenital glaucoma on 2p21 results from mutations disrupting either the hinge region or the conserved core structures of cytochrome P4501B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Amino acid prodrugs of acyclovir as possible antiviral agents against ocular HSV-1 infections: interactions with the neutral and cationic amino acid transporter on the corneal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Transcorneal-paracorneal penetration route for topical application of drugs to the eyt. Mycophenolate mofetil as a model substance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

The ocular pharmacokinetics of ketanserin and its metabolite, ketanserinol, in albino rabbits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

Characterization of glutathione S-transferases of human cornea

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.562195

10.1517/17425255.2011.562195

21 January 2018

Identifiers

DOI

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24 August 2017

1 reference