An evolutionary strategy for a stealthy intracellular Brucella pathogen (Q37846874)

24 August 2017

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title

An evolutionary strategy for a stealthy intracellular Brucella pathogen (English)

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24 August 2017

3

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24 August 2017

Anna Martirosyan

1

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PubMed ID

21349096

24 August 2017

Edgardo Moreno

series ordinal

2

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24 August 2017

1 March 2011

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24 August 2017

Immunological Reviews

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24 August 2017

240

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24 August 2017

1

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24 August 2017

211-234

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Brucella abortus 16S rRNA and lipid A reveal a phylogenetic relationship with members of the alpha-2 subdivision of the class Proteobacteria

24 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

The alpha-proteobacteria: the Darwin finches of the bacterial world

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Biological diversity of prokaryotic type IV secretion systems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

The BatR/BatS two-component regulatory system controls the adaptive response of Bartonella henselae during human endothelial cell infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

A two-component regulatory system playing a critical role in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the onset of infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Brucella abortus induces Irgm3 and Irga6 expression via type-I IFN by a MyD88-dependent pathway, without the requirement of TLR2, TLR4, TLR5 and TLR9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Brucella control of dendritic cell maturation is dependent on the TIR-containing protein Btp1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCE

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

A cellular basis of immunity in experimental Brucella infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Placental pathology of the pregnant mouse inoculated with Brucella abortus strain 2308.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Heterogeneous shedding of Brucella abortus in milk and its effect on the control of animal brucellosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Pathology of striped dolphins (Stenella coeruleoalba) infected with Brucella ceti

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Brucella: a Mr "Hide" converted into Dr Jekyll

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Activation of Rho and Rab GTPases dissociates Brucella abortus internalization from intracellular trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

In vitro Brucella suis infection prevents the programmed cell death of human monocytic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Brucella-Salmonella lipopolysaccharide chimeras are less permeable to hydrophobic probes and more sensitive to cationic peptides and EDTA than are their native Brucella sp. counterparts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

BvrR/BvrS-controlled outer membrane proteins Omp3a and Omp3b are not essential for Brucella abortus virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Bactericidal activity of Lys49 and Asp49 myotoxic phospholipases A2 from Bothrops asper snake venom--synthetic Lys49 myotoxin II-(115-129)-peptide identifies its bactericidal region.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

The differential interaction of Brucella and ochrobactrum with innate immunity reveals traits related to the evolution of stealthy pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Deletion of wboA enhances activation of the lectin pathway of complement in Brucella abortus and Brucella melitensis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Identification of Brucella spp. genes involved in intracellular trafficking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Enteropathogenic Escherichia coli mediates antiphagocytosis through the inhibition of PI 3-kinase-dependent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

COPII-dependent transport from the endoplasmic reticulum

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

COPII: a membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Brucella coopts the small GTPase Sar1 for intracellular replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Essential role of the VirB machinery in the maturation of the Brucella abortus-containing vacuole

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

The phagosome proteome: insight into phagosome functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

The glyceraldehyde-3-phosphate dehydrogenase and the small GTPase Rab 2 are crucial for Brucella replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Ptl type IV secretion systems is essential for intracellular survival of Brucella suis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Agrobacterium tumefaciens T-complex transport apparatus: a paradigm for a new family of multifunctional transporters in eubacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Pertussis toxin export requires accessory genes located downstream from the pertussis toxin operon

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

IcmS-dependent translocation of SdeA into macrophages by the Legionella pneumophila type IV secretion system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Absence of evidence for the participation of the macrophage cellular prion protein in infection with Brucella suis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Cyclic β-1,2-glucan is a brucella virulence factor required for intracellular survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

The Brucella suis virB operon is induced intracellularly in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Characterization of Brucella abortus and Brucella melitensis native haptens as outer membrane O-type polysaccharides independent from the smooth lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Brucellosis vaccines: assessment of Brucella melitensis lipopolysaccharide rough mutants defective in core and O-polysaccharide synthesis and export

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Characterization of Brucella abortus lipopolysaccharide macrodomains as mega rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

GTPases of the Rho subfamily are required for Brucella abortus internalization in nonprofessional phagocytes: direct activation of Cdc42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Extensive Cell Envelope Modulation Is Associated with Virulence inBrucella abortus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

A quorum-sensing regulator controls expression of both the type IV secretion system and the flagellar apparatus of Brucella melitensis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Transcriptome analysis of the Brucella abortus BvrR/BvrS two-component regulatory system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Modulation of Brucella-induced macropinocytosis by lipid rafts mediates intracellular replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

The IFNgamma-induced STAT1-CBP/P300 association, required for a normal response to the cytokine, is disrupted in Brucella-infected macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

RNAi screen of endoplasmic reticulum-associated host factors reveals a role for IRE1alpha in supporting Brucella replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Intracellular adaptation of Brucella abortus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

The innate immune response against Brucella in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Brucella: functional genomics and host-pathogen interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Brucella melitensis triggers time-dependent modulation of apoptosis and down-regulation of mitochondrion-associated gene expression in mouse macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Killing of Brucella antigen-sensitized macrophages by T lymphocytes in bovine brucellosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Host immune responses to the intracellular bacteria Brucella: does the bacteria instruct the host to facilitate chronic infection?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Bordetella type III secretion modulates dendritic cell migration resulting in immunosuppression and bacterial persistence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Brucella suis prevents human dendritic cell maturation and antigen presentation through regulation of tumor necrosis factor alpha secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Major outer membrane protein Omp25 of Brucella suis is involved in inhibition of tumor necrosis factor alpha production during infection of human macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

MyD88, but not toll-like receptors 4 and 2, is required for efficient clearance of Brucella abortus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Synthesis of phosphatidylcholine, a typical eukaryotic phospholipid, is necessary for full virulence of the intracellular bacterial parasite Brucella abortus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Brucella abortus and its closest phylogenetic relative, Ochrobactrum spp., differ in outer membrane permeability and cationic peptide resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

The sheathed flagellum of Brucella melitensis is involved in persistence in a murine model of infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Interaction of endotoxins with Toll-like receptor 4 correlates with their endotoxic potential and may explain the proinflammatory effect of Brucella spp. LPS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

The preparation of a lipidic endotoxin affects its biological activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Brucella abortus inhibits major histocompatibility complex class II expression and antigen processing through interleukin-6 secretion via Toll-like receptor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Lipoproteins, not lipopolysaccharide, are the key mediators of the proinflammatory response elicited by heat-killed Brucella abortus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Lipopeptide structure determines TLR2 dependent cell activation level

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Bacterial manipulation of innate immunity to promote infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Th1-like cytokine induction by heat-killed Brucella abortus is dependent on triggering of TLR9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Interferon-gamma promotes abortion due to Brucella infection in pregnant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Mouse cytokine profiles associated with Brucella abortus RB51 vaccination or B. abortus 2308 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Delayed type hypersensitivity-associated disruption of splenic periarteriolar lymphatic sheaths coincides with temporary loss of IFN-gamma production and impaired eradication of bacteria in Brucella abortus-infected mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Brucella abortus RB51 induces protection in mice orally infected with the virulent strain B. abortus 2308.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Recombinant Brucella abortus proteins that induce proliferation and gamma-interferon secretion by CD4+ T cells from Brucella-vaccinated mice and delayed-type hypersensitivity in sensitized guinea pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Susceptibility of IFN regulatory factor-1 and IFN consensus sequence binding protein-deficient mice to brucellosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Mice lacking components of adaptive immunity show increased Brucella abortus virB mutant colonization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Antigen-specific activation and proliferation of CD4+ and CD8+ T lymphocytes from brucellosis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Dominant Th1 cytokine production in early onset of human brucellosis followed by switching towards Th2 along prolongation of disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

V gamma 9V delta 2 T cells impair intracellular multiplication of Brucella suis in autologous monocytes through soluble factor release and contact-dependent cytotoxic effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Human CD4+ invariant NKT cells are involved in antibacterial immunity against Brucella suis through CD1d-dependent but CD4-independent mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

CD8+ type 1 CD44hi CD45 RBlo T lymphocytes control intracellular Brucella abortus infection as demonstrated in major histocompatibility complex class I- and class II-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Chronic brucellosis patients retain low frequency of CD4+ T-lymphocytes expressing CD25 and CD28 after Escherichia coli LPS stimulation of PHA-cultured PBMCs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Cognate CD4(+) T cell licensing of dendritic cells in CD8(+) T cell immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Brucella abortus Lipopolysaccharide in Murine Peritoneal Macrophages Acts as a Down-Regulator of T Cell Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

The O-chain of Brucella abortus lipopolysaccharide induces SDS-resistant MHC class II molecules in mouse B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Major histocompatibility complex class I and II expression on macrophages containing a virulent strain of Brucella abortus measured using green fluorescent protein-expressing brucellae and flow cytometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Identification and characterization of a novel bacterial virulence factor that shares homology with mammalian Toll/interleukin-1 receptor family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Brucella TIR Domain-containing Protein Mimics Properties of the Toll-like Receptor Adaptor Protein TIRAP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Biochemical and functional analysis of TIR domain containing protein from Brucella melitensis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Subversion of innate immune responses by Brucella through the targeted degradation of the TLR signaling adapter, MAL

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Brucella bacteremia reactivation 70 years after the primary infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Evaluation of the relatedness of Brucella spp. and Ochrobactrum anthropi and description of Ochrobactrum intermedium sp. nov., a new species with a closer relationship to Brucella spp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Molecular events involved in cellular invasion by Ehrlichia chaffeensis and Anaplasma phagocytophilum

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Frontline: control of Anaplasma phagocytophilum, an obligate intracellular pathogen, in the absence of inducible nitric oxide synthase, phagocyte NADPH oxidase, tumor necrosis factor, Toll-like receptor (TLR)2 and TLR4, or the TLR adaptor molecule M

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Recombinant Ochrobactrum anthropi expressing Brucella abortus Cu,Zn superoxide dismutase protects mice against B. abortus infection only after switching of immune responses to Th1 type

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Brucella Intracellular Replication Requires Trafficking Through the Late Endosomal/Lysosomal Compartment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

CD4+CD25+ T regulatory cells limit effector T cells and favor the progression of brucellosis in BALB/c mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Immunopathological responses and kinetics of Brucella melitensis Rev 1 infection after subcutaneous or conjunctival vaccination in rams

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

Intracellular rescuing of a B. melitensis 16M virB mutant by co-infection with a wild type strain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

MyD88-Dependent Activation of B220-CD11b+LY-6C+ Dendritic Cells during Brucella melitensis Infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2010.00982.X

10.1111/J.1600-065X.2010.00982.X

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference

PubMed ID

21349096