Anticonvulsant neuropeptides as drug leads for neurological diseases (Q37845684)

24 August 2017

1 reference

title

Anticonvulsant neuropeptides as drug leads for neurological diseases (English)

1 reference

24 August 2017

Charles R Robertson

1

1 reference

24 August 2017

Sean P Flynn

series ordinal

2

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24 August 2017

H Steve White

series ordinal

3

1 reference

24 August 2017

Grzegorz Bulaj

series ordinal

4

1 reference

24 August 2017

21 February 2011

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24 August 2017

Natural Product Reports

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24 August 2017

28

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24 August 2017

4

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24 August 2017

741-762

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Diversity of the neurotoxic Conus peptides: a model for concerted pharmacological discovery

24 August 2017

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Conus venoms - a rich source of peptide-based therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Key factors in the discovery and development of new antiepileptic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Epidemiology of refractory neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Neuropeptide Y: its multiple effects in the CNS and potential clinical significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Antiepileptic drugs in non-epilepsy disorders: relations between mechanisms of action and clinical efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Galanin impairs cognitive abilities in rodents: relevance to Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Somatostatinergic systems in brain: networks and functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine tumours, current aspects and new perspectives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Adeno-associated virus-mediated expression and constitutive secretion of galanin suppresses limbic seizure activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Recombinant AAV-mediated expression of galanin in rat hippocampus suppresses seizure development

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Anticonvulsant and antiepileptogenic effects mediated by adeno-associated virus vector neuropeptide Y expression in the rat hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Adeno-associated virus-mediated expression and constitutive secretion of NPY or NPY13-36 suppresses seizure activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Anticonvulsant effects and behavioural outcomes of rAAV serotype 1 vector-mediated neuropeptide Y overexpression in rat hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Delivering multiple gene products in the brain from a single adeno-associated virus vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Galanin and spinal pain mechanisms: where do we stand in 2008?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Galanin and galanin receptors in epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Galanin and its receptors in neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Regulation of limbic status epilepticus by hippocampal galanin type 1 and type 2 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Galanin, galanin receptors and drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Behavioral effects of neuropeptides in rodent models of depression and anxiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

21 January 2018

Galanin and addiction

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Galanin in Alzheimer's disease: neuroinhibitory or neuroprotective?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Anticonvulsive effects of galanin administered into the central nervous system upon the picrotoxin-kindled seizure syndrome in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Anticonvulsant activity of a nonpeptide galanin receptor agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Patterns of seizures, hippocampal injury and neurogenesis in three models of status epilepticus in galanin receptor type 1 (GalR1) knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Critical role for GALR1 galanin receptor in galanin regulation of neuroendocrine function and seizure activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure-induced neurogenesis in the dentate gyrus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Phenotypic analysis of mice deficient in the type 2 galanin receptor (GALR2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Hypothalamic degradation of galanin(1–29) and galanin(1–16): identification and characterization of the peptidolytic products

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Mutagenesis and ligand modification studies on galanin binding to its GTP-binding-protein-coupled receptor GalR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Important pharmacophores for binding to galanin receptor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Molecular characterization of the ligand binding site of the human galanin receptor type 2, identifying subtype selective interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Binding and agonist/antagonist actions of M35, galanin(1-13)-bradykinin(2-9)amide chimeric peptide, in Rin m 5F insulinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

21 January 2018

Galanin receptor ligands

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Galanin--10 years with a neuroendocrine peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Bioavailability and transport of peptides and peptide drugs into the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Peptide drug modifications to enhance bioavailability and blood-brain barrier permeability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Glycosylated neuropeptides: a new vista for neuropsychopharmacology?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Strategies to improve plasma half life time of peptide and protein drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Delivery of peptides to the brain: emphasis on therapeutic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Design, synthesis, and characterization of high-affinity, systemically-active galanin analogues with potent anticonvulsant activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Developing novel antiepileptic drugs: characterization of NAX 5055, a systemically-active galanin analog, in epilepsy models

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

A novel GalR2-specific peptide agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Synthesis of galmic: a nonpeptide galanin receptor agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

2,3-Dihydro-dithiin and -dithiepine-1,1,4,4-tetroxides: small molecule non-peptide antagonists of the human galanin hGAL-1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Galnon--a low-molecular weight ligand of the galanin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Multiple interaction sites of galnon trigger its biological effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Alterations in nociception and body temperature after intracisternal administration of neurotensin, beta-endorphin, other endogenous peptides, and morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Potentiation by thiorphan and bestatin of the naloxone-insensitive analgesic effects of neurotensin and neuromedin n.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Neurotensin and pain modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Hypothermia and intolerance to cold induced by intracisternal administration of the hypothalamic peptide neurotensin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Novel treatments of schizophrenia: targeting the neurotensin system

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Glycosylated neurotensin analogues exhibit sub-picomolar anticonvulsant potency in a pharmacoresistant model of epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Permeability of the blood-brain barrier to the neurotensin8-13 analog NT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Structure and functional expression of the cloned rat neurotensin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Molecular cloning of a levocabastine-sensitive neurotensin binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Functional roles of the NTS2 and NTS3 receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Heightened amygdala long-term potentiation in neurotensin receptor type-1 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Bioactive analogs of neurotensin: focus on CNS effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Neurotensin: role in psychiatric and neurological diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Cancer, chemistry, and the cell: molecules that interact with the neurotensin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Neurotensin enhances GABAergic activity in rat hippocampus CA1 region by modulating L-type calcium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Neurotensin: specific binding to synaptic membranes from rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Synthesis and characterization of neurotensin analogues for structure/activity relationship studies. Acetyl-neurotensin-(8--13) is the shortest analogue with full binding and pharmacological activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Proposed ligand binding site of the transmembrane receptor for neurotensin(8-13).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Investigation of ligand-receptor systems by high-resolution solid-state NMR: recent progress and perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

NMR solution structure of neurotensin in membrane-mimetic environments: molecular basis for neurotensin receptor recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Peptide backbone modifications on the C-terminal hexapeptide of neurotensin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Mutagenesis and modeling of the neurotensin receptor NTR1. Identification of residues that are critical for binding SR 48692, a nonpeptide neurotensin antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Impaired G protein coupling of the neurotensin receptor 1 by mutations in extracellular loop 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

In vitro binding and CNS effects of novel neurotensin agonists that cross the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Neurotensin: peptide for the next millennium

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Synthesis and biological effects of c(Lys-Lys-Pro-Tyr-Ile-Leu-Lys-Lys-Pro-Tyr-Ile-Leu) (JMV2012), a new analogue of neurotensin that crosses the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Synthesis and applications of polyamine amino acid residues: improving the bioactivity of an analgesic neuropeptide, neurotensin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Comparison of N-terminal modifications on neurotensin(8-13) analogues correlates peptide stability but not binding affinity with in vivo efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

In vivo behavioral effects of stable, receptor-selective neurotensin[8-13] analogues that cross the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Topography of the neurotensin (NT)(8-9) binding site of human NT receptor-1 probed with NT(8-13) analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Identification and functional characterization of a stable, centrally active derivative of the neurotensin (8-13) fragment as a potential first-in-class analgesic

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Contulakin-G, an O-glycosylated invertebrate neurotensin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

An assessment of the antinociceptive efficacy of intrathecal and epidural contulakin-G in rats and dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

The pharmacokinetics of the conopeptide contulakin-G (CGX-1160) after intrathecal administration: an analysis of data from studies in beagles

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Effects of SR 48692 on neurotensin-induced calcium-activated chloride currents in the Xenopus oocyte expression system: agonist-like activity on the levocabastine-sensitive neurotensin receptor and absence of antagonist effect on the levocabastine i

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Pharmacological properties of the mouse neurotensin receptor 3. Maintenance of cell surface receptor during internalization of neurotensin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Characterization of binding sites of a new neurotensin receptor antagonist, [3H]SR 142948A, in the rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Distinct functional characteristics of levocabastine sensitive rat neurotensin NT2 receptor expressed in Chinese hamster ovary cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Pharmacology and functional properties of NTS2 neurotensin receptors in cerebellar granule cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Evidence for a displaceable non-specific [3H]neurotensin binding site in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Neuropeptide Y: complete amino acid sequence of the brain peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Structure-activity relationships of neuropeptide Y analogues with respect to Y1 and Y2 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

X-ray analysis (1. 4-A resolution) of avian pancreatic polypeptide: Small globular protein hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

The Conformation, Flexibility, and Dynamics of Polypeptide Hormones

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Conformational flexibility in a small globular hormone: x-ray analysis of avian pancreatic polypeptide at 0.98-A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

The anti-epileptic actions of neuropeptide Y in the hippocampus are mediated by Y and not Y receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Neuropeptide Y Distribution in the Rat Brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Electrical kindling of the hippocampus is associated with functional activation of neuropeptide Y-containing neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Neuropeptide Y in the recurrent mossy fiber pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Presynaptic action of neuropeptide Y in area CA1 of the rat hippocampal slice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Antiepileptic actions of neuropeptide Y in the mouse hippocampus require Y5 receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Characterization of neuropeptide Y receptor subtypes in the normal human brain, including the hypothalamus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Blockade of neuropeptide Y(2) receptors and suppression of NPY's anti-epileptic actions in the rat hippocampal slice by BIIE0246

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Role of the Y5 neuropeptide Y receptor in limbic seizures

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Differential suppression of seizures via Y2 and Y5 neuropeptide Y receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Neuropeptide Y Y5 receptors inhibit kindling acquisition in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Molecular characterization of the ligand-receptor interaction of the neuropeptide Y family

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Complete L-alanine scan of neuropeptide Y reveals ligands binding to Y1 and Y2 receptors with distinguished conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Molecular recognition of the NPY hormone family by their receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Re-evaluation of receptor-ligand interactions of the human neuropeptide Y receptor Y1: a site-directed mutagenesis study

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Mutagenesis of human neuropeptide Y/peptide YY receptor Y2 reveals additional differences to Y1 in interactions with highly conserved ligand positions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

GPC receptors and not ligands decide the binding mode in neuropeptide Y multireceptor/multiligand system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Neuropeptide Y Y2 receptor in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Solution structure of human neuropeptide Y

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Structure and dynamics of micelle-bound neuropeptide Y: comparison with unligated NPY and implications for receptor selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Stabilization of the helical structure of Y2-selective analogues of neuropeptide Y by lactam bridges

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Modified, cyclic dodecapeptide analog of neuropeptide Y is the smallest full agonist at the human Y2receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

A novel cyclic analog of neuropeptide Y specific for the Y2 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

99mTc-labeled neuropeptide Y analogues as potential tumor imaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Protein design as a challenge for peptide chemists

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

BIIE0246: a selective and high affinity neuropeptide Y Y(2) receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y(2) receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Irreversible binding kinetics of neuropeptide Y ligands to Y2 but not to Y1 and Y5 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Novel non-peptidic neuropeptide Y Y2 receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Differential distribution of neuropeptide Y Y1 and Y2 receptors in rat and guinea-pig brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Opportunities in somatostatin research: biological, chemical and therapeutic aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Decreased hippocampal inhibition and a selective loss of interneurons in experimental epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

A selective loss of somatostatin in the hippocampus of patients with temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Somatostatin: an endogenous antiepileptic

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

A peptidase-resistant cyclic octapeptide analogue of somatostatin (SMS 201–995) modulates seizures induced by quinolinic and kainic acids differently in the rat hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Effects of somatostatin and anti-somatostatin serum on picrotoxin-kindled seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Anti-somatostatin antibody enhances the rate of hippocampal kindling in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Acromegaly pathogenesis and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Octreotide: a potent new non-opiate analgesic for intrathecal infusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Somatostatin in the central nervous system: physiology and pathological modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Anticonvulsant effects of four neuropeptides in the rat hippocampus during self-sustaining status epilepticus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Permeability of the murine blood-brain barrier to some octapeptide analogs of somatostatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Saturable efflux of the peptides RC-160 and Tyr-MIF-1 by different parts of the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Permeability of porcine blood brain barrier to somatostatin analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Novel insights in somatostatin receptor physiology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Characterisation of [125I]-Tyr0DTrp8-somatostatin binding in sst1- to sst4- and SRIF-gene-invalidated mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Somatostatin receptor subtype 4 couples to the M-current to regulate seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Superagonism at the human somatostatin receptor subtype 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Multiconformational NMR analysis of sandostatin (octreotide): equilibrium between beta-sheet and partially helical structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Highly active cyclic and bicyclic somatostatin analogues of reduced ring size

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Highly potent and subtype selective ligands derived by N-methyl scan of a somatostatin antagonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

SMS 201–995: A very potent and selective octapeptide analogue of somatostatin with prolonged action

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Lanreotide for the treatment of acromegaly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Design, synthesis, and biological activities of potent and selective somatostatin analogues incorporating novel peptoid residues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

A new peptidic somatostatin agonist with high affinity to all five somatostatin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

PEGylation of octreotide: II. Effect of N-terminal mono-PEGylation on biological activity and pharmacokinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Site-specific PEGylation of protein disulfide bonds using a three-carbon bridge

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Selective somatostatin sst(2) receptor blockade with the novel cyclic octapeptide, CYN-154806.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Highly potent cyclic disulfide antagonists of somatostatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Somatostatin receptor subtype specificity in human fetal pituitary cultures. Differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

A tumor-selective somatostatin analog (TT-232) with strong in vitro and in vivo antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Analgesic effect of TT-232, a heptapeptide somatostatin analogue, in acute pain models of the rat and the mouse and in streptozotocin-induced diabetic mechanical allodynia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Novel, potent, and radio-iodinatable somatostatin receptor 1 (sst1) selective analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Somatostatin receptor 1 selective analogues: 4. Three-dimensional consensus structure by NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Recent advances in the development of nonpeptide somatostatin receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Modulation of receptor and receptor subtype affinities using diastereomeric and enantiomeric monosaccharide scaffolds as a means to structural and biological diversity. A new route to ether synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Effects of Heterocyclic Aromatic Substituents on Binding Affinities at Two Distinct Sites of Somatostatin Receptors. Correlation with the Electrostatic Potential of the Substituents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Optimization of a somatostatin mimetic via constrained amino acid and backbone incorporation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Differential efficacies of somatostatin receptor agonists for G-protein activation and desensitization of somatostatin receptor subtype 4-mediated responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Effects of the somatostatin receptor subtype 4 selective agonist J-2156 on sensory neuropeptide release and inflammatory reactions in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Endogenous opiates and behavior: 2008.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Endogenous opiates and behavior: 2007.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Endogenous opioids and feeding behavior: a 30-year historical perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Molecular biology of opioid analgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

CNS drug delivery: opioid peptides and the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

30 years of dynorphins--new insights on their functions in neuropsychiatric diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Dynorphin is contained within hippocampal mossy fibers: immunochemical alterations after kainic acid administration and colchicine-induced neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Epilepsy, CNS viral injury and dynorphin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Opioid peptide release in the rat hippocampus after kainic acid-induced status epilepticus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Endogenous dynorphin in epileptogenesis and epilepsy: anticonvulsant net effect via kappa opioid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Temporal lobe epilepsy causes selective changes in mu opioid and nociceptin receptor binding and functional coupling to G-proteins in human temporal neocortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Increased mu-opioid receptor labeling is found on inner molecular layer terminals of the dentate gyrus following seizures

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Anticonvulsant Met-enkephalin analogues containing backbone spacers reveal alternative non-opioid signaling in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Endogenous opioid peptides: multiple agonists and receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the delta opioid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Natural peptide analgesics: the role of solution conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

A multidimensional 1H NMR investigation of the conformation of methionine-enkephalin in fast-tumbling bicelles

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

The depression of thalamic nociceptive neurones by D-ala2,D-leu5-enkephalin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Acyloxyalkoxy-based cyclic prodrugs of opioid peptides: evaluation of the chemical and enzymatic stability as well as their transport properties across Caco-2 cell monolayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Evaluation of the permeation characteristics of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs across the blood-brain barrier using an in situ perfused rat brain model

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Antinociceptive structure-activity studies with enkephalin-based opioid glycopeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Structure–activity relationships of dynorphin analogs substituted in positions 2 and 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Structure−Activity Relationships of Dynorphin A Analogues Modified in the Address Sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Studies on the anticonvulsant effect of U50488H on maximal electroshock seizure in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Behavioral effects of systemically administered mu and kappa opioid agonists in the squirrel monkey: peptides versus alkaloids

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Orphanin-FQ/nociceptin inhibits kindling epileptogenesis and enhances hippocampal feed-forward inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Involvement of the neuropeptide orphanin FQ/nociceptin in kainate and kindling seizures and epileptogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Delayed epileptogenesis in nociceptin/orphanin FQ-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Effects of nociceptin on the spread and seizure activity in the rat amygdala kindling model: their correlations with 3H-leucyl-nociceptin binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Delta sleep-inducing peptide (DSIP): a still unresolved riddle

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Epilepsy and reproductive disorders: the role of the gonadotropin-releasing hormone network.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Successful treatment of hypothalamic seizures and precocious puberty with GnRH analogue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Analgesic neuropeptide W suppresses seizures in the brain revealed by rational repositioning and peptide engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Synthetic therapeutic peptides: science and market

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

Peptide drugs to target G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

A functional polymorphism in the prodynorphin gene promotor is associated with temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

A potent cyclic hexapeptide analogue of somatostatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00048E

21 January 2018

Identifiers

DOI

10.1039/C0NP00048E

1 reference

24 August 2017

1 reference