Structure and function of histone H3 lysine 9 methyltransferases and demethylases (Q37829702)

24 August 2017

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title

Structure and function of histone H3 lysine 9 methyltransferases and demethylases (English)

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24 August 2017

Swathi Krishnan

1

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PubMed ID

21243713

24 August 2017

Scott Horowitz

series ordinal

2

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PubMed ID

21243713

24 August 2017

Raymond C Trievel

series ordinal

3

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24 August 2017

5 January 2011

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24 August 2017

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24 August 2017

12

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24 August 2017

254-263

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24 August 2017

2

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Nucleosome and chromatin fiber dynamics

24 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Chromatin modifications and their function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Covalent modifications of histones during development and disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

The complex language of chromatin regulation during transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Histone H3 lysine 9 methylation occurs rapidly at the onset of random X chromosome inactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Differential histone H3 Lys-9 and Lys-27 methylation profiles on the X chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

High-resolution profiling of histone methylations in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Epigenetic dynamics of imprinted X inactivation during early mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Partitioning and plasticity of repressive histone methylation states in mammalian chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Coordinated chromatin control: structural and functional linkage of DNA and histone methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

The SET-domain protein superfamily: protein lysine methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

SET domain protein lysine methyltransferases: Structure, specificity and catalysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Regulation of chromatin structure by site-specific histone H3 methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Unsafe SETs: histone lysine methyltransferases and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

The Universal Protein Resource (UniProt) in 2010

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Role of histone methyltransferase G9a in CpG methylation of the Prader-Willi syndrome imprinting center

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

5-Aza-2'-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

G9a and Glp methylate lysine 373 in the tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Histone-modifying enzymes: encrypting an enigmatic epigenetic code

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

A knot or not a knot? SETting the record 'straight' on proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Mechanism of multiple lysine methylation by the SET domain enzyme Rubisco LSMT

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Structure and catalytic mechanism of the human histone methyltransferase SET7/9

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Structural basis for the product specificity of histone lysine methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Regulation of p53 activity through lysine methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Structural basis for the methylation site specificity of SET7/9

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Regulation of Estrogen Receptor α by the SET7 Lysine Methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Specificity and mechanism of the histone methyltransferase Pr-Set7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Protein methyltransferases as a target class for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Analysis of the substrate specificity of the Dim-5 histone lysine methyltransferase using peptide arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Protein lysine methyltransferase G9a acts on non-histone targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Sequence specificity and role of proximal amino acids of the histone H3 tail on catalysis of murine G9A lysine 9 histone H3 methyltransferase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Structural origins for the product specificity of SET domain protein methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Catalytic roles for carbon-oxygen hydrogen bonding in SET domain lysine methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

SET7/9 Catalytic Mutants Reveal the Role of Active Site Water Molecules in Lysine Multiple Methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Functional analysis of the N- and C-terminus of mammalian G9a histone H3 methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Roles of the EZH2 histone methyltransferase in cancer epigenetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

The polycomb group protein EZH2 is involved in progression of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Enhanced SMYD3 expression is essential for the growth of breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

JmjC-domain-containing proteins and histone demethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

A novel mutation in the PHF8 gene is associated with X-linked mental retardation with cleft lip/cleft palate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Screening of mutations in the PHF8 gene and identification of a novel mutation in a Finnish family with XLMR and cleft lip/cleft palate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

The X-linked mental retardation gene PHF8 is a histone demethylase involved in neuronal differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

PHF8 targets histone methylation and RNA polymerase II to activate transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Structural insights into a novel histone demethylase PHF8

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Structural insights into histone demethylation by JMJD2 family members.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Structural basis of the recognition of a methylated histone tail by JMJD2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Structural Insights of the Specificity and Catalysis of a Viral Histone H3 Lysine 27 Methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

21 January 2018

Identifiers

DOI

10.1002/CBIC.201000545

1 reference

24 August 2017

1 reference

PubMed ID

21243713