Exploiting tyrosinase expression and activity in melanocytic tumors: quercetin and the central role of p53. (Q37825339)

23 August 2017

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title

Exploiting tyrosinase expression and activity in melanocytic tumors: quercetin and the central role of p53. (English)

1 reference

23 August 2017

6

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author name string

Ashley J Vargas

1

1 reference

23 August 2017

Sivanandane Sittadjody

2

1 reference

23 August 2017

Thilakavathy Thangasamy

3

1 reference

23 August 2017

Erin E Mendoza

4

1 reference

23 August 2017

Kirsten H Limesand

5

1 reference

23 August 2017

31 December 2010

1 reference

Integrative Cancer Therapies

23 August 2017

1 reference

23 August 2017

10

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23 August 2017

328-340

1 reference

23 August 2017

4

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Melanoma biology and new targeted therapy

23 August 2017

1 reference

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Synthesis and analysis of urea and carbamate prodrugs as candidates for melanocyte-directed enzyme prodrug therapy (MDEPT).

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Melanogenesis-targeted anti-melanoma pro-drug development: effect of side-chain variations on the cytotoxicity of tyrosinase-generated ortho-quinones in a model screening system.

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Prodrug cancer gene therapy.

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Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy

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In vitro studies of 2,4-dihydroxyphenylalanine, a prodrug targeted against malignant melanoma cells

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4-S-cysteaminylphenol and its analogues as substrates for tyrosinase and monoamine oxidase

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Tyrosinase activated melanoma prodrugs.

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Structural organization of the human tyrosinase gene and sequence analysis and characterization of its promoter region.

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Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene

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Human glioblastoma ADF cells express tyrosinase, L-tyrosine hydroxylase and melanosomes and are sensitive to L-tyrosine and phenylthiourea.

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Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma

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Quercetin selectively inhibits bioreduction and enhances apoptosis in melanoma cells that overexpress tyrosinase

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Selective incorporation and specific cytocidal effect as the cellular basis for the antimelanoma action of sulphur containing tyrosine analogs

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Identification of o-quinone/quinone methide metabolites of quercetin in a cellular in vitro system.

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Quercetin enhances melanogenesis by increasing the activity and synthesis of tyrosinase in human melanoma cells and in normal human melanocytes

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Quercetin-induced melanogenesis in a reconstituted three-dimensional human epidermal model

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p53, the cellular gatekeeper for growth and division

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Death squads enlisted by the tumour suppressor p53.

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Tyrosinase gene expression is regulated by p53.

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Expression of p73, a novel protein related to the p53 tumour suppressor p53, and apoptosis in cholangiocellular carcinoma of the liver

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DeltaN-p73alpha accumulates in human neuroblastic tumors

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Quercetin abrogates chemoresistance in melanoma cells by modulating deltaNp73.

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Triggering and modulation of apoptosis by oxidative stress

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The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX.

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No PUMA, no death: implications for p53-dependent apoptosis

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PUMA, a novel proapoptotic gene, is induced by p53

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Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells

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Role of p53 up-regulated modulator of apoptosis and phosphorylated Akt in melanoma cell growth, apoptosis, and patient survival

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The p53 pathway and its inactivation in neuroblastoma.

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The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90.

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NQO1 stabilizes p53 through a distinct pathway

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Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Calpha

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Absorption of three wine-related polyphenols in three different matrices by healthy subjects

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Identifiers

DOI

10.1177/1534735410391661

1 reference

23 August 2017

1 reference