Natural glycoconjugates with antitumor activity (Q37814157)

23 August 2017

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title

Natural glycoconjugates with antitumor activity (English)

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23 August 2017

4

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Francisco Cardona

5

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Cristina Airoldi

2

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Barbara La Ferla

1

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Giuseppe D'Orazio

object named as

Giuseppe D'Orazio

8

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author name string

Cristiano Zona

3

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23 August 2017

Silvia Merlo

6

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23 August 2017

Erika Sironi

7

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23 August 2017

Francesco Nicotra

9

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23 August 2017

30 November 2010

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23 August 2017

Natural Product Reports

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23 August 2017

28

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23 August 2017

3

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23 August 2017

630-648

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From carbohydrate leads to glycomimetic drugs

23 August 2017

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

The role of carbohydrates in biologically active natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Sweet antibiotics - the role of glycosidic residues in antibiotic and antitumor activity and their randomization

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Callipeltoside a: total synthesis, assignment of the absolute and relative configuration, and evaluation of synthetic analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Enantioselective total synthesis of callipeltoside A: two approaches to the macrolactone fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Lyngbouilloside, a novel glycosidic macrolide from the marine cyanobacterium Lyngbya bouillonii

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Antineoplastic Agents. 510. Isolation and structure of dolastatin 19 from the Gulf of California sea hare Dolabella auricularia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Cross resistance pattern towards anticancer drugs of a human carcinoma multidrug-resistant cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

New dimeric macrolide glycosides from the marine sponge Myriastra clavosa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Total synthesis of the marine natural product (-)-clavosolide A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Total synthesis of a diastereomer of the marine natural product clavosolide A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Total synthesis of the marine metabolite (-)-clavosolide D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Biselyngbyaside, a macrolide glycoside from the marine cyanobacterium Lyngbya sp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Semisynthetic derivatives of concanamycin A and C, as inhibitors of V- and P-type ATPases: structure-activity investigations and developments of photoaffinity probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Folimycin (concanamycin A), an inhibitor of V-type H(+)-ATPase, blocks cell-surface expression of virus-envelope glycoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Apoptolidins B and C: isolation, structure determination, and biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Isolation, structure determination, and anti-cancer activity of apoptolidin D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Apoptolidins E and F, new glycosylated macrolactones isolated from Nocardiopsis sp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Combined chemical and biosynthetic route to access a new apoptolidin congener

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Apoptolidin: induction of apoptosis by a natural product

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Targeting anthracyclines in early breast cancer: new candidate predictive biomarkers emerge

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Effect of structural modification at the 4, 3', and 2' positions of doxorubicin on topoisomerase II poisoning, apoptosis, and cytotoxicity in human melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Novel anthracycline oligosaccharides: influence of chemical modifications of the carbohydrate moiety on biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Role of the sugar moiety in the pharmacological activity of anthracyclines: development of a novel series of disaccharide analogs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Role of the amino sugar in the DNA binding of disaccharide anthracyclines: crystal structure of the complex MAR70/d(CGATCG).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

In vitro modeling of the structure-activity determinants of anthracycline cardiotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Syntheses and biological activities of daunorubicin analogs with uncommon sugars

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Advantages of liposomal delivery systems for anthracyclines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Improved therapeutic activity of folate-targeted liposomal doxorubicin in folate receptor-expressing tumor models

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

PEGylated PLGA nanoparticles for the improved delivery of doxorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Multiple functions of generic drugs: future perspectives of aureolic acid group of anti-cancer antibiotics and non-steroidal anti-inflammatory drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Inhibition of c-src transcription by mithramycin: structure-activity relationships of biosynthetically produced mithramycin analogues using the c-src promoter as target

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Mithramycin SK, A Novel Antitumor Drug with Improved Therapeutic Index, Mithramycin SA, and Demycarosyl-mithramycin SK: Three New Products Generated in the Mithramycin Producer Streptomyces argillaceus through Combinatorial Biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal nov

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Mithramycin inhibits human epithelial carcinoma cell proliferation and migration involving downregulation of Eps8 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Differential inhibition of restriction enzyme cleavage by chromophore-modified analogues of the antitumour antibiotics mithramycin and chromomycin reveals structure-activity relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Reaction of the antitumor antibiotic olivomycin I with aryl diazonium salts. Synthesis, cytotoxic and antiretroviral potency of 5-aryldiazenyl-6-O-deglycosyl derivatives of olivomycin I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

The effects of local DNA sequence on the interaction of ligands with their preferred binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Crystal structure of the [Mg2+-(chromomycin A3)2]-d(TTGGCCAA)2 complex reveals GGCC binding specificity of the drug dimer chelated by a metal ion

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Solution structure of the novel antitumor drug UCH9 complexed with d(TTGGCCAA)2 as determined by NMR

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Non-covalent ligand/DNA interactions: minor groove binding agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Inhibition of Sp1-dependent transcription and antitumor activity of the new aureolic acid analogues mithramycin SDK and SK in human ovarian cancer xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Bleomycin: Synthetic and Mechanistic Studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Glycopeptide antitumor antibiotic zorbamycin from Streptomyces flavoviridis ATCC 21892: strain improvement and structure elucidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Bleomycin: new perspectives on the mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Curing metastatic testicular cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Bleomycins: towards better therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Deglycosylated bleomycin triggers apoptosis in laryngeal carcinoma cells in a caspase and reactive oxygen species independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Biochemical evaluation of a 108-member deglycobleomycin library: viability of a selection strategy for identifying bleomycin analogues with altered properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Conformationally constrained analogues of bleomycin A5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Synthesis, biological evaluation and DNA binding properties of novel bleomycin analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Novel peptide derivatives of bleomycin A5: synthesis, antitumor activity and interaction with DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Isolation and characterization of antibiotic NC0604, a new analogue of bleomycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Fungal polysaccharopeptide inhibits tumor angiogenesis and tumor growth in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

NMR characterization for polysaccharide moiety of a glycopeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Structure-activity relationship studies for the peptide portion of the bladder epithelial cell antiproliferative factor from interstitial cystitis patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

A new class of natural glycopeptides with sugar moiety-dependent antioxidant activities derived from Ganoderma lucidum fruiting bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Muramyl peptides augment cytotoxic effect of tumor necrosis factor-alpha in combination with cytotoxic drugs on tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Pharmacology and therapeutic applications of enediyne antitumor antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Natural products as sources of new drugs over the last 25 years

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

21 January 2018

The enediyne antibiotics

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

The carbohydrate domain of calicheamicin gamma I1 determines its sequence specificity for DNA cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Calicheamicin-DNA complexes: warhead alignment and saccharide recognition of the minor groove

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Chemistry and biology of natural and designed enediynes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Cyanosporasides A and B, chloro- and cyano-cyclopenta[a]indene glycosides from the marine actinomycete "Salinispora pacifica".

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Free-radical mechanisms involved in the formation of sequence-dependent bistranded DNA lesions by the antitumor antibiotics bleomycin, neocarzinostatin, and calicheamicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

DNA intercalation and cleavage of an antitumor antibiotic dynemicin that contains anthracycline and enediyne cores

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

DNA cleavage characteristics of non-protein enediyne antibiotic N1999A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Kedarcidin chromophore: an enediyne that cleaves DNA in a sequence-specific manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Selective proteolytic activity of the antitumor agent kedarcidin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

A continuous assay for DNA cleavage: the application of "break lights" to enediynes, iron-dependent agents, and nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

p-Benzyne. Generation as an intermediate in a thermal isomerization reaction and trapping evidence for the 1,4-benzenediyl structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Neocarzinostatin-mediated DNA damage in a model AGT.ACT site: mechanistic studies of thiol-sensitive partitioning of C4' DNA damage products

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Single chemical modifications of the C-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Antibody-targeted chemotherapy with the calicheamicin conjugate hu3S193-N-acetyl gamma calicheamicin dimethyl hydrazide targets Lewisy and eliminates Lewisy-positive human carcinoma cells and xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Antibody-targeted chemotherapy with immunoconjugates of calicheamicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

CMC-544 (inotuzumab ozogamicin), an anti-CD22 immuno-conjugate of calicheamicin, alters the levels of target molecules of malignant B-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

The Benzoxazolinate of C-1027 Confers Intercalative DNA Binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

DNA Damage Produced by Enediynes in the Human Phosphoglycerate Kinase Gene in Vivo: Esperamicin A1 as a Nucleosome Footprinting Agent†

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Aurisides A and B, Cytotoxic Macrolide Glycosides from the Japanese Sea HareDolabella auricularia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0NP00055H

Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.50.628

Dynemicin A, a novel antibiotic with the anthraquinone and 1,5-diyn-3-ene subunit

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.42.1449

The structure and absolute configuration of the 18-membered macrolide lactone antibiotic X-4357B (concanamycin A)

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.37.1738

Isolation and characterization of concanamycins A, B and C

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.37.1333

Identifiers

DOI

10.1039/C0NP00055H

1 reference

23 August 2017

1 reference