Cryptorchidism and hypospadias as a sign of testicular dysgenesis syndrome (TDS): environmental connection (Q37791999)

23 August 2017

Cryptorchidism and hypospadias as a sign of testicular dysgenesis syndrome (TDS): environmental connection (English)

1 reference

Testicular dysgenesis syndrome

23 August 2017

1 reference

1

Jorma Toppari

1 reference

23 August 2017

4

Niels E Skakkebaek

1 reference

23 August 2017

Helena E Virtanen

2

1 reference

PubMed ID

20865786

23 August 2017

Katharina M Main

series ordinal

3

1 reference

23 August 2017

1 October 2010

1 reference

Birth Defects Research Part A: Clinical and Molecular Teratology

23 August 2017

1 reference

23 August 2017

88

1 reference

23 August 2017

10

1 reference

23 August 2017

910-919

1 reference

Is the incidence of hypospadias increasing? Analysis of Finnish hospital discharge data 1970-1994.

23 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Maternal and gestational risk factors for hypospadias

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Neural tube defects and drinking water disinfection by-products

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Linkage between cryptorchidism, hypospadias, and GGN repeat length in the androgen receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Undescended testis: current theories of etiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Insulin-like factor 3 levels in cord blood and serum from children: effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Polymorphisms of estrogen receptor beta gene are associated with hypospadias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Increase in testicular cancer incidence in six European countries: a birth cohort phenomenon

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Hypospadias in a cohort of 1072 Danish newborn boys: prevalence and relationship to placental weight, anthropometrical measurements at birth, and reproductive hormone levels at three months of age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Difference in prevalence of congenital cryptorchidism in infants between two Nordic countries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Hypospadias: a transgenerational effect of diethylstilbestrol?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Hypospadias: risk factor patterns and different phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Aetiological factors in hypospadias

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Sperm count of young men surgically treated for cryptorchidism in the first and second year of life: fertility is better in children treated at a younger age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Hypospadias in California: trends and descriptive epidemiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

The true incidence of cryptorchidism in Denmark.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

The incidence of disorders of sexual differentiation and chromosomal abnormalities of cryptorchidism and hypospadias stratified by meatal location.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Aetiological Studies of Hypospadias in Hungary

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Endocrine regulation of HOX genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Cryptorchidism and maternal alcohol consumption during pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Risk factors for congenital cryptorchidism in a prospective birth cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Persistent pesticides in human breast milk and cryptorchidism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Clinical epidemiology of testicular germ cell tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Toward the effective surveillance of hypospadias

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Surgical outcome of orchidopexy. II. Trapped and ascending testes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

No association between T222P/LGR8 mutation and cryptorchidism in the Moroccan population

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Hypospadias rates in new york state are not increasing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Human 'testicular dysgenesis syndrome': a possible model using in-utero exposure of the rat to dibutyl phthalate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Role of hormones, genes, and environment in human cryptorchidism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

A novel duplication in the HOXA13 gene in a family with atypical hand-foot-genital syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

CXorf6 is a causative gene for hypospadias

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Mutations of the GREAT gene cause cryptorchidism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Adverse effects of environmental antiandrogens and androgens on reproductive development in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Prevalence of acquired undescended testis in 6-year, 9-year and 13-year-old Dutch schoolboys

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Infertility in cryptorchidism is linked to the stage of germ cell development at orchidopexy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Cryptorchidism: a registry based study in Sweden on some factors of possible aetiological importance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Is there a correlation between organochlorine compounds and undescended testes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Reduced birth weight in boys with hypospadias: an index of androgen dysfunction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Seasonal variations in cryptorchidism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Combined exposure to endocrine disrupting pesticides impairs parturition, causes pup mortality and affects sexual differentiation in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Trends in testicular cancer incidence in the Nordic countries, focusing on the recent decrease in Denmark.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

The orl rat with inherited cryptorchidism has increased susceptibility to the testicular effects of in utero dibutyl phthalate exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Prenatal risk factors for cryptorchidism: a record linkage study

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Regional differences in semen quality in Europe

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

East-West gradient in semen quality in the Nordic-Baltic area: a study of men from the general population in Denmark, Norway, Estonia and Finland.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Is hypospadias a genetic, endocrine or environmental disease, or still an unexplained malformation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Hypospadias in sons of women exposed to diethylstilbestrol in utero: a cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Combined exposures to anti-androgenic chemicals: steps towards cumulative risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

A common polymorphism in the human relaxin-like factor (RLF) gene: no relationship with cryptorchidism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Country-specific chemical signatures of persistent environmental compounds in breast milk

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

The ascending testis: is late orchidopexy due to failure of screening or late ascent?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Fertility after bilateral cryptorchidism. Evaluation by paternity, hormone, and semen data

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Effects of developmental exposure to 2,2 ,4,4 ,5-pentabromodiphenyl ether (PBDE-99) on sex steroids, sexual development, and sexually dimorphic behavior in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Activating transcription factor 3 is estrogen-responsive in utero and upregulated during sexual differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Activating transcription factor 3 is up-regulated in patients with hypospadias

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Prevalence of hypospadias in Danish boys: a longitudinal study, 1977-2005.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Larger testes and higher inhibin B levels in Finnish than in Danish newborn boys.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

From malformations to molecular mechanisms in the male: three decades of research on endocrine disrupters

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Mutation of HOXA13 in hand-foot-genital syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Increasing prevalence of hypospadias in Western Australia, 1980-2000

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Cryptorchidism in mice mutant for Insl3

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

A molecular basis for estrogen-induced cryptorchidism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

A maternal vegetarian diet in pregnancy is associated with hypospadias. The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

The leucine-rich repeat-containing G protein-coupled receptor 8 gene T222P mutation does not cause cryptorchidism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

MAMLD1 (CXorf6): a new gene involved in hypospadias

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

MAMLD1 (CXorf6): a new gene for hypospadias

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

International trends in rates of hypospadias and cryptorchidism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Hypospadias trends in two US surveillance systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Sonic hedgehog signaling from the urethral epithelium controls external genital development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Developmental and reproductive toxicity of dioxins and related compounds: cross-species comparisons

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Age at surgery for undescended testis and risk of testicular cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Maternal and paternal risk factors for cryptorchidism and hypospadias: a case-control study in newborn boys

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Hypospadias in Washington State: maternal risk factors and prevalence trends.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Androgen receptor defects: historical, clinical, and molecular perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Serum androgen bioactivity in cryptorchid and noncryptorchid boys during the postnatal reproductive hormone surge

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Fetal genital effects of first-trimester sex hormone exposure: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Low risk of impaired testicular Sertoli and Leydig cell functions in boys with isolated hypospadias

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Cumulative effects of in utero administration of mixtures of reproductive toxicants that disrupt common target tissues via diverse mechanisms of toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Cryptorchidism and homeotic transformations of spinal nerves and vertebrae in Hoxa-10 mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Nordic consensus on treatment of undescended testes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Pesticides and hypospadias: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Lack of LGR8 gene mutation in Finnish patients with a family history of cryptorchidism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

THE DESCENT OF THE TESTIS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

The 'oestrogen hypothesis'- where do we stand now?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Enantiomeric ratios as an indicator of exposure processes for persistent pollutants in human placentas

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Effects of fifteen PBDE metabolites, DE71, DE79 and TBBPA on steroidogenesis in the H295R cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

In vivo and in vitro anti-androgenic effects of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Hormonal changes in 3-month-old cryptorchid boys

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

The herbicide atrazine activates endocrine gene networks via non-steroidal NR5A nuclear receptors in fish and mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Environmental endocrine disrupters

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Trends in the incidence of cryptorchidism and hypospadias, and methodological limitations of registry-based data

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Male reproductive health and environmental xenoestrogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Cryptorchidism: classification, prevalence and long-term consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

The birth rate of hypospadias in the Turku area in Finland.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Epidemiology and pathogenesis of cryptorchidism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Prepubertal orchiopexy for cryptorchidism may be associated with lower risk of testicular cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Endocrine disruptors, genital development, and hypospadias

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Analysis of five single nucleotide polymorphisms in the ESR1 gene in cryptorchidism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Haplotype analysis of the estrogen receptor 1 gene in male genital and reproductive abnormalities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Cryptorchidism and hypospadias in sons of gardeners and farmers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Risk factors for cryptorchidism and hypospadias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Immunoexpression of androgen receptor and nine markers of maturation in the testes of adolescent boys with Klinefelter syndrome: evidence for degeneration of germ cells at the onset of meiosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Klinefelter syndrome in adolescence: onset of puberty is associated with accelerated germ cell depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Candidate genes and their response to environmental agents in the etiology of hypospadias

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Association of cryptorchidism with a specific haplotype of the estrogen receptor alpha gene: implication for the susceptibility to estrogenic environmental endocrine disruptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Targeted disruption of the Insl3 gene causes bilateral cryptorchidism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

FGFR2, FGF8, FGF10 and BMP7 as candidate genes for hypospadias

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

Genetics of Hypospadias: Are Single-Nucleotide Polymorphisms inSRD5A2,ESR1,ESR2, andATF3Really Associated with the Malformation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

The descriptive epidemiology of congenital and acquired cryptorchidism in a UK infant cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20707

21 January 2018

Identifiers

DOI

10.1002/BDRA.20707

1 reference

23 August 2017

1 reference

PubMed ID

20865786