The expanding role of H1 antihistamines: a patent survey of selective and dual activity compounds 2005-2010. (Q37780551)

23 August 2017

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title

The expanding role of H1 antihistamines: a patent survey of selective and dual activity compounds 2005-2010. (English)

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23 August 2017

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Graham Beaton

1

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23 August 2017

Wilna J Moree

series ordinal

2

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23 August 2017

language of work or name

English

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publication date

1 September 2010

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Expert Opinion on Therapeutic Patents

23 August 2017

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23 August 2017

20

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23 August 2017

9

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23 August 2017

1197-1218

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Histamine in the immune regulation of allergic inflammation

23 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Overview of allergic rhinitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Allergic rhinitis and its impact on asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Antihistamines as analgesics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

H1-receptors: localization and role in airway physiology and in immune functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

H1-Antihistamines: more relevant than ever in the treatment of allergic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Ligand-directed functional heterogeneity of histamine H1 receptors: novel dual-function ligands selectively activate and block H1-mediated phospholipase C and adenylyl cyclase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Constitutive activity of the histamine H(1) receptor reveals inverse agonism of histamine H(1) receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Histamine H1 receptor induces cytosolic calcium increase and aquaporin translocation in human salivary gland cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Consensus statement on the treatment of allergic rhinitis. European Academy of Allergology and Clinical Immunology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Second-generation antihistamines: the risk of ventricular arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

The metabolism of antihistamines and drug interactions: the role of cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Consensus Group on New-Generation Antihistamines (CONGA): present status and recommendations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Levocetirizine for the treatment of allergic rhinitis and chronic idiopathic urticaria in adults and children.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Theophylline as 'add-on' therapy to cetirizine in patients with chronic idiopathic urticaria. A randomized, double-blind, placebo-controlled pilot study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Effect of combined histamine H1 and H3 receptor blockade on cutaneous microvascular permeability elicited by compound 48/80.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

The effect of a novel, dual function histamine H1 receptor antagonist/5-lipoxygenase enzyme inhibitor on in vivo dermal inflammation and extravasation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

A dual antagonist for chemokine CCR3 receptor and histamine H1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Effects of a dual CCR3 and H1-antagonist on symptoms and eosinophilic inflammation in allergic rhinitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Dual acting antihistaminergic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Interactions of histamine H1-receptor agonists and antagonists with the human histamine H4-receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Rupatadine and its effects on symptom control, stimulation time, and temperature thresholds in patients with acquired cold urticaria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Interactions of olopatadine and selected antihistamines with model and natural membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Olopatadine: a drug for allergic conjunctivitis targeting the mast cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Bepotastine besilate, a highly selective histamine H(1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Characterization of novel selective H1-antihistamines for clinical evaluation in the treatment of insomnia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

A pharmacokinetic evaluation of five H(1) antagonists after an oral and intravenous microdose to human subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

5-HT(2A) inverse-agonists for the treatment of insomnia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

ReN 1869, a novel tricyclic antihistamine, is active against neurogenic pain and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Effect of microinjection of histamine into the dorsal hippocampus on the orofacial formalin-induced pain in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Histamine H3 and H4 receptors as novel drug targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

A clinical drug library screen identifies astemizole as an antimalarial agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Chloroquine-astemizole hybrids with potent in vitro and in vivo antiplasmodial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Histamine H3 receptor ligands break ground in a remarkable plethora of therapeutic areas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Histamine H3 receptor activation inhibits neurogenic sympathetic vasoconstriction in porcine nasal mucosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Activation of histamine H3 receptors in human nasal mucosa inhibits sympathetic vasoconstriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Bacteriologic findings from the nose, ethmoid, and bloodstream during endoscopic surgery for chronic rhinosinusitis: implications for antibiotic therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Histamine receptors that influence blockage of the normal human nasal airway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Synthesis and structure-activity relationships of phenothiazine carboxylic acids having pyrimidine-dione as novel histamine H(1) antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Residual effects of hypnotics: epidemiology and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Histaminergic control of sleep-wake cycles: recent therapeutic advances for sleep and wake disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Novel therapeutic usage of low-dose doxepin hydrochloride

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Long-term use of antidepressants for depressive disorders and the risk of diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Mutational analysis of the antagonist-binding site of the histamine H(1) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Brain-penetrating 2-aminobenzimidazole H(1)-antihistamines for the treatment of insomnia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Novel benzothiophene H1-antihistamines for the treatment of insomnia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Selectivity profiling of novel indene H(1)-antihistamines for the treatment of insomnia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

The discovery and structure-activity relationships of 2-(piperidin-3-yl)-1H-benzimidazoles as selective, CNS penetrating H1-antihistamines for insomnia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

Synthesis and pharmacological identification of neutral histamine H1-receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510516

10.1517/13543776.2010.510516

21 January 2018

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DOI

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release_xat426wky5hkpmej6gsxnwzaei

23 August 2017

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