Molecular mechanisms controlling human adipose tissue development: insights from monogenic lipodystrophies (Q37776761)

23 August 2017

1 reference

title

Molecular mechanisms controlling human adipose tissue development: insights from monogenic lipodystrophies (English)

1 reference

23 August 2017

Justin J Rochford

1

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language of work or name

English

1 reference

National Center for Biotechnology Information

PubMed ID

20673380

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20673380

13 June 2024

publication date

2 August 2010

1 reference

PubMed ID

20673380

full work available at URL

23 August 2017

https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S1462399410001547

1 reference

https://api.crossref.org/works/10.1017/S1462399410001547

Expert Reviews in Molecular Medicine

13 June 2024

published in

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23 August 2017

12

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23 August 2017

e24

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Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities

23 August 2017

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

LMNA, encoding lamin A/C, is mutated in partial lipodystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Fat and beyond: the diverse biology of PPARgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Phenotypic Heterogeneity in Body Fat Distribution in Patients with Congenital Generalized Lipodystrophy Caused by Mutations in the AGPAT2 or Seipin Genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Fat depot-specific characteristics are retained in strains derived from single human preadipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Beneficial effects of subcutaneous fat transplantation on metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Cidea-deficient mice have lean phenotype and are resistant to obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Cideb regulates diet-induced obesity, liver steatosis, and insulin sensitivity by controlling lipogenesis and fatty acid oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

The Akt-SREBP nexus: cell signaling meets lipid metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

The forkhead transcription factor FoxC2 inhibits white adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Filling up adipocytes with lipids. Lessons from caveolin-1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Role of caveolae and caveolins in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Diacylglycerol, when simplicity becomes complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Antileukemic activity of lysophosphatidic acid acyltransferase-beta inhibitor CT32228 in chronic myelogenous leukemia sensitive and resistant to imatinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Dynamics of fat cell turnover in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Disordered lipid metabolism and the pathogenesis of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Mouse models of inherited lipodystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Role of Foxa-2 in adipocyte metabolism and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Transcriptional factors that promote formation of white adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

The forkhead transcription factor Foxo1 regulates adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

On the role of FOX transcription factors in adipocyte differentiation and insulin-stimulated glucose uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

New developments in adipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Regional differences of insulin action in adipose tissue: insights from in vivo and in vitro studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Lipid droplets in lipogenesis and lipolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Activation of protein kinase B/Akt is sufficient to repress the glucocorticoid and cAMP induction of phosphoenolpyruvate carboxykinase gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Acyl-CoA:lysophospholipid acyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Biochemical and physiological function of stearoyl-CoA desaturase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Seipin deficiency alters fatty acid Delta9 desaturation and lipid droplet formation in Berardinelli-Seip congenital lipodystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

The human lipodystrophy gene product Berardinelli-Seip congenital lipodystrophy 2/seipin plays a key role in adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Heterozygous missense mutations in BSCL2 are associated with distal hereditary motor neuropathy and Silver syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Differential regulation of endogenous glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression by the forkhead transcription factor FKHR in H4IIE-hepatoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Active and inactive protein kinases: structural basis for regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

A family with severe insulin resistance and diabetes due to a mutation in AKT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Lipid droplets at a glance

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Endocrine functions of adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Lipodystrophy in HIV 1-infected patients: lessons for obesity research

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

HIV-associated lipodystrophy: a review of underlying mechanisms and therapeutic options

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Genetic disorders of adipose tissue development, differentiation, and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Thematic review series: Adipocyte Biology. Lipodystrophies: windows on adipose biology and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Lipodystrophies: disorders of adipose tissue biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Effects of troglitazone on fat distribution in the treatment of male type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Adipogenesis and lipotoxicity: role of peroxisome proliferator-activated receptor gamma (PPARgamma) and PPARgammacoactivator-1 (PGC1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

A futile metabolic cycle activated in adipocytes by antidiabetic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Muscle-specific Pparg deletion causes insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

PPAR gamma and human metabolic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Functional implications of genetic variation in human PPARgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

PPAR gamma is required for placental, cardiac, and adipose tissue development

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Opposing roles of pRB and p107 in adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Seipin: a mysterious protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Association between nuclear lamin A/C R482Q mutation and partial lipodystrophy with hyperinsulinemia, dyslipidemia, hypertension, and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

The human lipodystrophy gene BSCL2/seipin may be essential for normal adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Nuclear lamin A inhibits adipocyte differentiation: implications for Dunnigan-type familial partial lipodystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Altered pre-lamin A processing is a common mechanism leading to lipodystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Failure of lamin A/C to functionally assemble in R482L mutated familial partial lipodystrophy fibroblasts: altered intermolecular interaction with emerin and implications for gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

SREBP in signal transduction: cholesterol metabolism and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Lipin1 is a key factor for the maturation and maintenance of adipocytes in the regulatory network with CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Genotype-phenotype relationships in Berardinelli-Seip congenital lipodystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Novel mutations of the BSCL2 and AGPAT2 genes in 10 families with Berardinelli-Seip congenital generalized lipodystrophy syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

"Laminopathies": a wide spectrum of human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Characterization of seipin/BSCL2, a protein associated with spastic paraplegia 17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Fat-specific protein 27 undergoes ubiquitin-dependent degradation regulated by triacylglycerol synthesis and lipid droplet formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Fat-specific protein 27 regulates storage of triacylglycerol

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Lipid droplet analysis in caveolin-deficient adipocytes: alterations in surface phospholipid composition and maturation defects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Regulated association of caveolins to lipid droplets during differentiation of 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Cholesterol-induced caveolin targeting to lipid droplets in adipocytes: a role for caveolar endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Role of caveolins in body weight and insulin resistance regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Membrane topology of the human seipin protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Caveolin-1 is required for fatty acid translocase (FAT/CD36) localization and function at the plasma membrane of mouse embryonic fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

Isoform-specific regulation of adipocyte differentiation by Akt/protein kinase Bα

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

7 January 2021

Effect of troglitazone on body fat distribution in type 2 diabetic patients

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

7 January 2021

Regional adiposity and morbidity

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

7 January 2021

Higher adiponectin levels in patients with Berardinelli-Seip congenital lipodystrophy due to seipin as compared with 1-acylglycerol-3-phosphate-o-acyltransferase-2 deficiency

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

7 January 2021

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

7 January 2021

Associations of hip and thigh circumferences independent of waist circumference with the incidence of type 2 diabetes: the Hoorn Study

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

7 January 2021

Effects of a thiazolidinedione compound on body fat and fat distribution of patients with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

7 January 2021

Substrate specificity of lysophosphatidic acid acyltransferase beta -- evidence from membrane and whole cell assays

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001547

7 January 2021

FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets

series ordinal

23

1 reference

https://api.crossref.org/works/10.1017/S1462399410001547

Heterogeneity of nuclear lamin A mutations in Dunnigan-type familial partial lipodystrophy

13 June 2024

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105

1 reference

https://api.crossref.org/works/10.1017/S1462399410001547

Inhibition of lysophosphatidic acid acyltransferase beta disrupts proliferative and survival signals in normal cells and induces apoptosis of tumor cells

13 June 2024

series ordinal

111

1 reference

https://api.crossref.org/works/10.1017/S1462399410001547

13 June 2024

Identifiers

1 reference

23 August 2017

1 reference

PubMed ID

20673380