Role of serum response factor in the pathogenesis of disease (Q37760418)

22 August 2017

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title

Role of serum response factor in the pathogenesis of disease (English)

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22 August 2017

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Joseph M Miano

1

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22 August 2017

24 May 2010

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22 August 2017

Laboratory Investigation

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22 August 2017

90

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22 August 2017

1274-1284

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22 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/labinvest.2010.104

22 August 2017

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cites work

Identification of functional SNPs in the 5-prime flanking sequences of human genes

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Natural selection on human microRNA binding sites inferred from SNP data

21 January 2018

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SNPs in human miRNA genes affect biogenesis and function

21 January 2018

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The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microRNA-155 binding

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

The MADS-box family of transcription factors

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Actin' together: serum response factor, its cofactors and the link to signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

The myocardin family of transcriptional coactivators: versatile regulators of cell growth, migration, and myogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Signal-regulated activation of serum response factor is mediated by changes in actin dynamics

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Actin dynamics control SRF activity by regulation of its coactivator MAL

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Myocardin: a component of a molecular switch for smooth muscle differentiation

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

RPEL motifs link the serum response factor cofactor MAL but not myocardin to Rho signaling via actin binding

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

MAL and ternary complex factor use different mechanisms to contact a common surface on the serum response factor DNA-binding domain.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Identification of direct serum-response factor gene targets during Me2SO-induced P19 cardiac cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Defining the mammalian CArGome

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Role of the serum response factor in regulating contractile apparatus gene expression and sarcomeric integrity in cardiomyocytes.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Serum response factor binding sites differ in three human cell types

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Serum response factor micromanaging cardiogenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Effect of destrin mutations on the gene expression profile in vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Serum response factor is essential for mesoderm formation during mouse embryogenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Generation of mice carrying conditional knockout alleles for the transcription factor SRF.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Restricted inactivation of serum response factor to the cardiovascular system

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Serum response factor, an enriched cardiac mesoderm obligatory factor, is a downstream gene target for Tbx genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Molecular pathways controlling heart development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Mosaic inactivation of the serum response factor gene in the myocardium induces focal lesions and heart failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Increased expression of alternatively spliced dominant-negative isoform of SRF in human failing hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

The history of the capillary wall: doctors, discoveries, and debates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Mechanisms of vessel branching: filopodia on endothelial tip cells lead the way.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Serum response factor is required for sprouting angiogenesis and vascular integrity

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Endothelial-specific ablation of serum response factor causes hemorrhaging, yolk sac vascular failure, and embryonic lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Developmental basis of vascular smooth muscle diversity

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Smooth muscle myosin heavy chain exclusively marks the smooth muscle lineage during mouse embryogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

SM22 alpha, a marker of adult smooth muscle, is expressed in multiple myogenic lineages during embryogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Expression of the smooth muscle cell calponin gene marks the early cardiac and smooth muscle cell lineages during mouse embryogenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Molecular regulation of vascular smooth muscle cell differentiation in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Expression of the SM22alpha promoter in transgenic mice provides evidence for distinct transcriptional regulatory programs in vascular and visceral smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Proliferation of human primary vascular smooth muscle cells depends on serum response factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Myogenic progenitor cells and skeletal myogenesis in vertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

New role for serum response factor in postnatal skeletal muscle growth and regeneration via the interleukin 4 and insulin-like growth factor 1 pathways

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Premature aging in skeletal muscle lacking serum response factor

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Marked reduction of focal adhesion kinase, serum response factor and myocyte enhancer factor 2C, but increase in RhoA and myostatin in the hindlimb dy mouse muscles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Hepatocyte expression of serum response factor is essential for liver function, hepatocyte proliferation and survival, and postnatal body growth in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Conditional inactivation of the murine serum response factor in the pancreas leads to severe pancreatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Severe intestinal obstruction on induced smooth muscle-specific ablation of the transcription factor SRF in adult mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Inducible mouse model of chronic intestinal pseudo-obstruction by smooth muscle-specific inactivation of the SRF gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Serum response factor promotes re-epithelialization and muscular structure restoration during gastric ulcer healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

A critical role of serum response factor in myofibroblast differentiation during experimental oesophageal ulcer healing in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Developmental expression of serum response factor in the rat central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Neuronal migration in the murine rostral migratory stream requires serum response factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Serum response factor controls neuronal circuit assembly in the hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Paracrine control of oligodendrocyte differentiation by SRF-directed neuronal gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Serum response factor regulates hippocampal lamination and dendrite development and is connected with reelin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Role of the reelin signaling pathway in central nervous system development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Neurovascular pathways and Alzheimer amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Alzheimer's disease is a vasocognopathy: a new term to describe its nature

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Serum response factor is essential for the proper development of skin epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Serum Response Factor Contributes Selectively to Lymphocyte Development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Co-occurrence of CArG boxes and TCF sites within viral genomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Identification of a functional serum response element in the HTLV-I LTR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Tissue inhibitor of metalloproteinase-3 downregulation in lymphangioleiomyomatosis: potential consequence of abnormal serum response factor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Stretch-induced alternative splicing of serum response factor promotes bronchial myogenesis and is defective in lung hypoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Involvement of serum response factor isoforms in myofibroblast differentiation during bleomycin-induced lung injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Cre-mediated recombination in mouse Clara cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Differential binding of an SRF/NK-2/MEF2 transcription factor complex in normal versus neoplastic smooth muscle tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Ionizing radiation activates transcription of the EGR1 gene via CArG elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

WebLogo: A Sequence Logo Generator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Serum response factor: toggling between disparate programs of gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

7 January 2021

Activation of ternary complex factor Elk-1 by MAP kinases

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

7 January 2021

Temporally controlled onset of dilated cardiomyopathy through disruption of the SRF gene in adult heart

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

7 January 2021

miR-145 and miR-143 regulate smooth muscle cell fate and plasticity

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

7 January 2021

Cardiomyopathy in transgenic mice with cardiac-specific overexpression of serum response factor.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

7 January 2021

Model of functional cardiac aging: young adult mice with mild overexpression of serum response factor

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

7 January 2021

Inhibitory cardiac transcription factor, SRF-N, is generated by caspase 3 cleavage in human heart failure and attenuated by ventricular unloading

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

7 January 2021

Circulation is established in a stepwise pattern in the mammalian embryo

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

7 January 2021

Delayed liver regeneration in mice lacking liver serum response factor

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

7 January 2021

Serum response factor is a critical requirement for VEGF signaling in endothelial cells and VEGF-induced angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

7 January 2021

Persistent increased DNA-binding and expression of serum response factor occur with epilepsy-associated long-term plasticity changes.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

7 January 2021

The serum response factor (SRF)/megakaryocytic acute leukemia (MAL) network participates in megakaryocyte development

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2010.104

7 January 2021

10.1038/LABINVEST.2010.104

Identifiers

DOI

1 reference

22 August 2017

1 reference

PubMed ID

20498652