Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer (Q37750751)

22 August 2017

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title

Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer (English)

1 reference

22 August 2017

Alexander Schultze

1

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PubMed ID

20465362

22 August 2017

Walter Fiedler

series ordinal

2

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PubMed ID

20465362

22 August 2017

language of work or name

English

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publication date

1 June 2010

1 reference

Expert Opinion on Investigational Drugs

22 August 2017

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22 August 2017

19

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22 August 2017

6

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22 August 2017

777-788

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Control of motile and invasive cell phenotypes by focal adhesion kinase.

22 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Focal adhesion kinase (p125FAK): a point of convergence in the action of neuropeptides, integrins, and oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Disruption of epithelial cell-matrix interactions induces apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Focal adhesion kinase is required for blood vessel morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Signal transduction by focal adhesion kinase in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Biochemical signals and biological responses elicited by the focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Focal adhesion kinase: a promising target for anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Role of focal adhesion kinase in human cancer: a potential target for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Focal adhesion kinase: a potential target in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Focal adhesion kinase: targeting adhesion signaling pathways for therapeutic intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Cloning and characterization of cell adhesion kinase beta, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

RAFTK/Pyk2-mediated cellular signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Regulation of endothelial cell function BY FAK and PYK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Focal adhesion kinase is overexpressed in hepatocellular carcinoma and can be served as an independent prognostic factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Expression and clinical significance of focal adhesion kinase in the two distinct histological types, intestinal and diffuse, of human gastric adenocarcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Expression of focal adhesion kinase in patients with endometrial cancer: a clinicopathologic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Prognostic value of CXCR4 and FAK expression in acute myelogenous leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Focal adhesion kinase expression is not a prognostic predictor in colon adenocarcinoma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Clinical significance of focal adhesion kinase in resectable pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

The direct effect of focal adhesion kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Targeting focal adhesion kinase with dominant-negative FRNK or Hsp90 inhibitor 17-DMAG suppresses tumor growth and metastasis of SiHa cervical xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Paradoxical roles of FAK in tumor cell migration and metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Angiogenesis in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

alphav beta 3 and alphav beta 5 integrin antagonists inhibit angiogenesis in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Cilengitide induces cellular detachment and apoptosis in endothelial and glioma cells mediated by inhibition of FAK/src/AKT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Tumor invasion after treatment of glioblastoma with bevacizumab: radiographic and pathologic correlation in humans and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Targeting Pyk2 for therapeutic intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

FERM control of FAK function: implications for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

A new paradigm for protein kinase inhibition: blocking phosphorylation without directly targeting ATP binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Structural Characterization of Proline-rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor Design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Cellular characterization of a novel focal adhesion kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

TAE226-induced apoptosis in breast cancer cells with overexpressed Src or EGFR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Dual tyrosine kinase inhibitor for focal adhesion kinase and insulin-like growth factor-I receptor exhibits anticancer effect in esophageal adenocarcinoma in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Inhibition of focal adhesion kinase as a potential therapeutic strategy for imatinib-resistant gastrointestinal stromal tumor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

SRC kinase inhibition: targeting bone metastases and tumor growth in prostate and breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Phase II study of dasatinib in patients with metastatic castration-resistant prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

RNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Intrinsic chemoresistance to gemcitabine is associated with constitutive and laminin-induced phosphorylation of FAK in pancreatic cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Knockdown of focal adhesion kinase reverses colon carcinoma multicellular resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

The effect of focal adhesion kinase gene silencing on 5-fluorouracil chemosensitivity involves an Akt/NF-kappaB signaling pathway in colorectal carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Induced focal adhesion kinase expression suppresses apoptosis by activating NF-kappaB signaling in intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Antisense oligonucleodes targeting the focal adhesion kinase inhibit proliferation, induce apoptosis and cooperate with cytotoxic drugs in human glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Focal adhesion kinase and protein kinase B cooperate to suppress doxorubicin-induced apoptosis of breast tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Anti-apoptotic role of focal adhesion kinase (FAK). Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Extracellular matrix-induced transforming growth factor-beta receptor signaling dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-beta signaling and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

Sunitinib and PF-562,271 (FAK/Pyk2 inhibitor) effectively block growth and recovery of human hepatocellular carcinoma in a rat xenograft model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

ANTI-ADHESION evolves to a promising therapeutic concept in oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.489548

10.1517/13543784.2010.489548

21 January 2018

Identifiers

DOI

1 reference

22 August 2017

1 reference

PubMed ID

20465362