Gap junctions and connexins as therapeutic targets in cancer (Q37743527)

22 August 2017

1 reference

title

Gap junctions and connexins as therapeutic targets in cancer (English)

1 reference

22 August 2017

Mustapha Kandouz

1

1 reference

PubMed ID

20446866

22 August 2017

Gerald Batist

series ordinal

2

1 reference

PubMed ID

20446866

22 August 2017

language of work or name

English

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publication date

1 July 2010

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Expert Opinion on Therapeutic Targets

22 August 2017

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22 August 2017

14

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22 August 2017

7

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22 August 2017

681-692

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Connexins and cell signaling in development and disease

22 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Gap junction channel structure in the early 21st century: facts and fantasies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Connexin43 phosphorylation: structural changes and biological effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Defective gap junctional intercellular communication in the carcinogenic process

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

The tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the ras oncogene modulate expression and phosphorylation of gap junction proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Epidermal growth factor regulates ubiquitination, internalization and proteasome-dependent degradation of connexin43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Cigarette smoke components inhibited intercellular communication and differentiation in human pancreatic ductal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Src-Induced cisplatin resistance mediated by cell-to-cell communication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Neoplastic reversal of human ovarian carcinoma cells transfected with connexin43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Connexins: a myriad of functions extending beyond assembly of gap junction channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Connexins and gap junctions in mammary gland development and breast cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Connexins act as tumor suppressors in three-dimensional mammary cell organoids by regulating differentiation and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Connexin-43 upregulation in micrometastases and tumor vasculature and its role in tumor cell attachment to pulmonary endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

A role for heterologous gap junctions between melanoma and endothelial cells in metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Alterations in Cx43 and OB-cadherin affect breast cancer cell metastatic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Expressing connexin 43 in breast cancer cells reduces their metastasis to lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Increased expression of connexins 26 and 43 in lymph node metastases of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Influence of the bystander effect on HSV-tk/GCV gene therapy. A review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Radiation-induced bystander signalling in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Lack of bystander killing in herpes simplex virus thymidine kinase-transduced colon cell lines due to deficient connexin43 gap junction formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Radiation-induced bystander effects--implications for cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Induction of a bystander effect in HeLa cells by using a bigenic vector carrying viral thymidine kinase and connexin32 genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Connexins as targets for cancer chemoprevention and chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

(-)-Epicatechin effects in rat liver epithelial cells: stimulation of gap junctional communication and counteraction of its loss due to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: relationship to their cancer chemopreventive action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Resveratrol reverses tumor-promoter-induced inhibition of gap-junctional intercellular communication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Upregulation of gap junctional intercellular communication and connexin 43 expression by cyclic-AMP and all-trans-retinoic acid is associated with glutathione depletion and chemosensitivity in neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Identification of a novel switch in the dominant forms of cell adhesion-mediated drug resistance in glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Connexin43 increases the sensitivity of prostate cancer cells to TNFalpha-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Combinational treatment of gap junctional activator and tamoxifen in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Regulation of the gap junction connexin 43 gene by androgens in the prostate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Functional gap junctions facilitate melanoma antigen transfer and cross-presentation between human dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Gene expression response to cisplatin treatment in drug-sensitive and drug-resistant ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

A derivative of oleamide potently inhibits the spontaneous metastasis of mouse melanoma BL6 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Gap junctions remain open during cytochrome c-induced cell death: relationship of conductance to 'bystander' cell killing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Mitochondrial apoptosis is amplified through gap junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Cross-presentation by intercellular peptide transfer through gap junctions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Direct antigen presentation and gap junction mediated cross-presentation during apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

A heterotypic bystander effect for tumor cell killing after adeno-associated virus/phage-mediated, vascular-targeted suicide gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Gap junction communication between autologous endothelial and tumor cells induce cross-recognition and elimination by specific CTL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Adenoviral delivery of human connexin37 induces endothelial cell death through apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

The anti-glioma effect of suicide gene therapy using BMSC expressing HSV/TK combined with overexpression of Cx43 in glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

HSV-tk expressing mesenchymal stem cells exert bystander effect on human glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Breast cancer metastatic potential: correlation with increased heterotypic gap junctional intercellular communication between breast cancer cells and osteoblastic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Bone marrow connexin-43 expression is critical for hematopoietic regeneration after chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Retroviral delivery of connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap junctional intercellular communication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Mutated connexin43 proteins inhibit rat glioma cell growth suppression mediated by wild-type connexin43 in a dominant-negative manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Beyond the gap: functions of unpaired connexon channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

The gap junction cellular internet: connexin hemichannels enter the signalling limelight

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Connexin 43 hemichannels contribute to the propagation of apoptotic cell death in a rat C6 glioma cell model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Cx43 mediates TGF-beta signaling through competitive Smads binding to microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Activation of protein kinase C in human uterine smooth muscle induces connexin-43 gene transcription through an AP-1 site in the promoter sequence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Unexpected induction of the human connexin 43 promoter by the ras signaling pathway is mediated by a novel putative promoter sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

HDACi phenylbutyrate increases bystander killing of HSV-tk transfected glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Effects of the histone deacetylases inhibitors sodium butyrate and trichostatin A on the inhibition of gap junctional intercellular communication by H2O2- and 12-O-tetradecanoylphorbol-13-acetate in rat liver epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

5-Aza-2'-deoxycytidine suppresses human renal carcinoma cell growth in a xenograft model via up-regulation of the connexin 32 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Overexpression of protease-activated receptor-1 contributes to melanoma metastasis via regulation of connexin 43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Ubiquitination of gap junction proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Gap junctions sensitize cancer cells to proteasome inhibitor MG132-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Phosphorylation of connexin43 induced by Src: regulation of gap junctional communication between transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Restoration of functional gap junctions through internal ribosome entry site-dependent synthesis of endogenous connexins in density-inhibited cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

MIR-206 regulates connexin43 expression during skeletal muscle development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

RNA-binding protein Dnd1 inhibits microRNA access to target mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Silencing of microRNAs in vivo with 'antagomirs'

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Connexin43 pseudogene is expressed in tumor cells and inhibits growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Connexin43 pseudogene in breast cancer cells offers a novel therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Identification of connexin-interacting proteins: application of the yeast two-hybrid screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Connexin 33 impairs gap junction functionality by accelerating connexin 43 gap junction plaque endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

The role of the cytoskeleton in the formation of gap junctions by Connexin 30.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Enhanced effect of connexin 43 on cisplatin-induced cytotoxicity in mesothelioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Enhancing effect of connexin 32 gene on vinorelbine-induced cytotoxicity in A549 lung adenocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Connexin 26 gene therapy of human bladder cancer: induction of growth suppression, apoptosis, and synergy with Cisplatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Mechanisms of Cx43 and Cx26 transport to the plasma membrane and gap junction regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

Internalization of large double-membrane intercellular vesicles by a clathrin-dependent endocytic process

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.487866

10.1517/14728222.2010.487866

21 January 2018

Identifiers

DOI

1 reference

22 August 2017

1 reference

PubMed ID

20446866