MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential (Q37741582)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

title

MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Maureen Shawn Kennedy

17

object named as

Maureen Kennedy

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

25

Tristan Vaughan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

13

Matthieu Chodorge

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

15

Daniel R Higazi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

author name string

Lisa Bamber

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

John Andrews

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Samantha Ireland

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

James Hair

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Edward Carter

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Sudharsan Sridharan

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Jelena Jovanović

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

D Gareth Rees

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Jeremy S Springall

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Emilie Solier

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Yi-Ming Li

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

David Perez-Martinez

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Michael Oberst

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Chelsea M Black

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Li Yan

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Martin Schwickart

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Shaun Maguire

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Jennifer A Cann

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Lolke de Haan

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Lesley L Young

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Robert W Wilkinson

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Ross Stewart

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

publication date

3 February 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

page(s)

e1280645

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International

17 March 2020

copyright license

start time

3 February 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial.

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

GITR pathway activation abrogates tumor immune suppression through loss of regulatory T cell lineage stability

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

OX40 is a potent immune-stimulating target in late-stage cancer patients

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Modulation of GITR for cancer immunotherapy

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Ipilimumab: first global approval

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Complex networks govern coiled-coil oligomerization--predicting and profiling by means of a machine learning approach

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Trimeric Structure of Langerin

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Glycosylation of therapeutic proteins: an effective strategy to optimize efficacy

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

1.8 Å structure of murine GITR ligand dimer expressed inDrosophila melanogasterS2 cells

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Evolution of GITRL immune function: Murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

A conserved trimerization motif controls the topology of short coiled coils

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

NMR structure of a parallel homotrimeric coiled coil

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Cell-specific and context-dependent effects of GITR in cancer, autoimmunity, and infection

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

A Novel Murine GITR Ligand Fusion Protein Induces Antitumor Activity as a Monotherapy That Is Further Enhanced in Combination with an OX40 Agonist

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Cutting edge: the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Modulation of Treg cells/T effector function by GITR signaling is context-dependent

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Molecular insights into the self-assembly mechanism of dystrophia myotonica kinase

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Trimer stabilization, oligomerization, and antibody-mediated cell surface immobilization improve the activity of soluble trimers of CD27L, CD40L, 41BBL, and glucocorticoid-induced TNF receptor ligand

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Calculating sedimentation coefficient distributions by direct modeling of sedimentation velocity concentration profiles

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Enrichment of regulatory T cells in invasive breast tumor correlates with the upregulation of IL-17A expression and invasiveness of the tumor

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5384396

Activated tumor-infiltrating CD4+ regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer

1 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28405505

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A unique subset of CD4+CD25highFoxp3+ T cells secreting interleukin-10 and transforming growth factor-beta1 mediates suppression in the tumor microenvironment

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28405505

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1080/2162402X.2017.1280645

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28405505%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

PubMed publication ID

28405505

1 reference