Immunity, thyroid function and pregnancy: molecular mechanisms (Q37737553)

22 August 2017

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title

Immunity, thyroid function and pregnancy: molecular mechanisms (English)

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22 August 2017

1

Anthony P Weetman

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22 August 2017

27 April 2010

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Nature Reviews Endocrinology

22 August 2017

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22 August 2017

6

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22 August 2017

6

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22 August 2017

311-318

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https://scigraph.springernature.com/pub.10.1038/nrendo.2010.46

22 August 2017

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Th1-type immunity is incompatible with successful pregnancy

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Effect of interleukin-10 null mutation on maternal immune response and reproductive outcome in mice.

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Regulatory T cells mediate maternal tolerance to the fetus

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Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases.

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Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset.

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Phenotypic characterization of regulatory T cells in the human decidua.

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Systemic reduction of functionally suppressive CD4dimCD25highFoxp3+ Tregs in human second trimester pregnancy is induced by progesterone and 17beta-estradiol.

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PD-1 but not CTLA-4 blockage abrogates the protective effect of regulatory T cells in a pregnancy murine model

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Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia

31 March 2020

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Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero

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12 December 2020

Autoantibodies as predictors of pregnancy complications

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12 December 2020

Maternal-fetal tolerance is maintained despite transgene-driven trophoblast expression of MHC class I, and defects in Fas and its ligand.

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12 December 2020

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

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12 December 2020

MYXOEDEMA IN YOUNG WOMEN

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12 December 2020

Lassitude, coldness, and hair changes following pregnancy, and their response to treatment with thyroid extract.

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12 December 2020

Identifiers

DOI

10.1038/NRENDO.2010.46

1 reference

22 August 2017

1 reference

PubMed ID

20421883