New-generation 5-HT4 receptor agonists: potential for treatment of gastrointestinal motility disorders (Q37735172)

22 August 2017

1 reference

title

New-generation 5-HT4 receptor agonists: potential for treatment of gastrointestinal motility disorders (English)

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22 August 2017

3

Michael Camilleri

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22 August 2017

1

Noriaki Manabe

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22 August 2017

Banny S Wong

2

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PubMed ID

20408739

22 August 2017

language of work or name

English

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publication date

1 June 2010

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Expert Opinion on Investigational Drugs

22 August 2017

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22 August 2017

19

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22 August 2017

6

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22 August 2017

765-775

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The serotonin signaling system: from basic understanding to drug development for functional GI disorders

22 August 2017

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https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Gastric accommodation and emptying in evaluation of patients with upper gastrointestinal symptoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Molecular, pharmacological and functional diversity of 5-HT receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Review article: serotonin receptors and transporters -- roles in normal and abnormal gastrointestinal motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Drugs acting on serotonin receptors for the treatment of functional GI disorders

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Triptans and gastric accommodation: pharmacological and therapeutic aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Effect of cisapride on delayed gastric emptying in gastro-oesophageal reflux disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Effect of cisapride on nocturnal transient lower oesophageal sphincter relaxations and nocturnal gastro-oesophageal reflux in patients with oesophagitis: a double-blind, placebo-controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

The effect of mosapride, a novel prokinetic, on acid reflux variables in patients with gastro-oesophageal reflux disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

5-Hydroxytryptamine4 receptor agonists and colonic motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Morphometric evaluation of oesophageal wall in patients with nutcracker oesophagus and ineffective oesophageal motility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Safety and tolerability of tegaserod in patients with chronic constipation: pooled data from two phase III studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Comparative effects of loratadine and terfenadine on cardiac K+ channels

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Molecular and cellular mechanisms of cardiac arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

HERG, a human inward rectifier in the voltage-gated potassium channel family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

5-HT4 receptor agonists: similar but not the same

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Cardiovascular responses produced by 5-hydroxytriptamine:a pharmacological update on the receptors/mechanisms involved and therapeutic implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

The gastrointestinal prokinetic benzamide derivatives are agonists at the non-classical 5-HT receptor (5-HT4) positively coupled to adenylate cyclase in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

5-HT4 receptors: cloning and expression of new splice variants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Translating 5-HT receptor pharmacology.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2010.482927

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

5-HT(4) receptors on cholinergic nerves involved in contractility of canine and human large intestine longitudinal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Effects of 5-HT4 receptor stimulation on basal and electrically evoked release of acetylcholine from guinea-pig myenteric plexus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Benzimidazolones and renzapride facilitate acetylcholine release from guinea-pig myenteric plexus via 5-HT4 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

5-Hydroxytryptamine4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Effect of cisapride on the gastrointestinal transit of a solid meal in normal human subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Tegaserod, a 5-HT4 receptor partial agonist, accelerates gastric emptying and gastrointestinal transit in healthy male subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, prucalopride, in healthy humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Prucalopride is effective in patients with severe chronic constipation in whom laxatives fail to provide adequate relief. Results of a double-blind, placebo-controlled clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Intestinal macrophages display reduced permissiveness to human immunodeficiency virus 1 and decreased surface CCR5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

A placebo-controlled trial of prucalopride for severe chronic constipation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation--a 12-week, randomized, double-blind, placebo-controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Prucalopride is a partial agonist through human and porcine atrial 5-HT4 receptors: comparison with recombinant human 5-HT4 splice variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Porcine left atrial and sinoatrial 5-HT(4) receptor-induced responses: fading of the response and influence of development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Selective desensitization of the 5-HT4 receptor-mediated response in pig atrium but not in stomach

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

The action of the novel gastrointestinal prokinetic prucalopride on the HERG K+ channel and the common T897 polymorph

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Safety assessment of prucalopride in elderly patients with constipation: a double-blind, placebo-controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Effects of prucalopride on colonic transit, anorectal function and bowel habits in patients with chronic constipation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Prucalopride, a systemic enterokinetic, for the treatment of constipation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Pharmacodynamic effects of a novel prokinetic 5-HT receptor agonist, ATI-7505, in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Colonoscopy: virtual, optical, or chromoscopic?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

Hepatic expression of candidate genes in patients with alcoholic hepatitis: correlation with disease severity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

The in vivo gastrointestinal activity of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2010.482927

10.1517/13543784.2010.482927

21 January 2018

Identifiers

DOI

1 reference

22 August 2017

1 reference

PubMed ID

20408739