Targeting TLR/IL-1R signalling in human diseases. (Q37731951)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20396389%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

review article

3 references

26 August 2020

3 November 2020

Targeting TLR/IL-1R signalling in human diseases (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20396389%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

2 references

4 August 2019

3 November 2020

cell surface receptor

1 reference

pattern recognition receptors

31 July 2019

1 reference

3 August 2019

1 reference

15 December 2019

1 reference

26 August 2020

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20396389%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

author name string

Maria Loiarro

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20396389%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Vito Ruggiero

series ordinal

2

1 reference

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31 January 2020

publication date

8 April 2010

7 references

31 July 2019

3 August 2019

4 August 2019

15 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20396389%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

26 August 2020

3 November 2020

Mediators of Inflammation

7 references

31 July 2019

3 August 2019

4 August 2019

15 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20396389%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

26 August 2020

3 November 2020

2010

1 reference

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31 January 2020

page(s)

674363

1 reference

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Creative Commons Attribution 3.0 Unported

31 January 2020

copyright license

6 references

31 July 2019

3 August 2019

4 August 2019

15 December 2019

26 August 2020

The role of toll-like receptors in chronic inflammation

3 November 2020

0 references

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852602

Toll-like receptors and NOD-like receptors: domain architecture and cellular signalling.

23 August 2017

1 reference

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Targeting Toll-like receptors in autoimmunity.

23 August 2017

1 reference

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Mannose-binding lectin and innate immunity

23 August 2017

1 reference

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Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling

23 August 2017

1 reference

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TLRs as therapeutic targets in CNS inflammation and infection

23 August 2017

1 reference

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How the immune system achieves self-nonself discrimination during adaptive immunity

23 August 2017

1 reference

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Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer.

23 August 2017

1 reference

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Potential pharmacological control of the NF-κB pathway

23 August 2017

1 reference

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Innate immunity and toll-like receptor antagonists: a potential role in the treatment of cardiovascular diseases

23 August 2017

1 reference

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Immunological and inflammatory functions of the interleukin-1 family

23 August 2017

1 reference

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The roles of TLRs, RLRs and NLRs in pathogen recognition

23 August 2017

1 reference

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Identification of potential pathway mediation targets in Toll-like receptor signaling

23 August 2017

1 reference

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The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress.

23 August 2017

1 reference

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Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

23 August 2017

1 reference

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Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock

23 August 2017

1 reference

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The role of nuclear factor-kappaB in the development of autoimmune diseases: a link between genes and environment.

23 August 2017

1 reference

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Toll-like receptors in autoimmunity

23 August 2017

1 reference

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Structures of the toll-like receptor family and its ligand complexes

23 August 2017

1 reference

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Pyogenic bacterial infections in humans with MyD88 deficiency

23 August 2017

1 reference

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Targeting toll-like receptor signaling pathways for design of novel immune therapeutics

23 August 2017

1 reference

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The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer

23 August 2017

1 reference

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TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

23 August 2017

1 reference

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Design, synthesis, and in vitro activity of peptidomimetic inhibitors of myeloid differentiation factor 88.

23 August 2017

1 reference

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The involvement of the interleukin-1 receptor-associated kinases (IRAKs) in cellular signaling networks controlling inflammation

23 August 2017

1 reference

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The future of toll-like receptor therapeutics.

23 August 2017

1 reference

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Novel primary immunodeficiencies revealed by the investigation of paediatric infectious diseases

23 August 2017

1 reference

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Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2.

23 August 2017

1 reference

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Toll-like receptors: novel pharmacological targets for the treatment of neurological diseases.

23 August 2017

1 reference

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Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity

23 August 2017

1 reference

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Toll-like receptors in inflammation, infection and cancer

23 August 2017

1 reference

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Targeting toll-like receptors for drug development: a summary of commercial approaches

23 August 2017

1 reference

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Role of the innate immune system in host defence against bacterial infections: focus on the Toll-like receptors

23 August 2017

1 reference

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Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists

23 August 2017

1 reference

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The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

23 August 2017

1 reference

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Nuclear factor-kappaB: activation and regulation during toll-like receptor signaling.

23 August 2017

1 reference

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Targeting protein-protein interactions by rational design: mimicry of protein surfaces

23 August 2017

1 reference

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Targeting signal transduction as a strategy to treat inflammatory diseases.

23 August 2017

1 reference

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Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

23 August 2017

1 reference

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The evolution of adaptive immune systems

23 August 2017

1 reference

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Pathogen recognition and innate immunity

23 August 2017

1 reference

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Binding specificity of Toll-like receptor cytoplasmic domains

23 August 2017

1 reference

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MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics

23 August 2017

1 reference

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23 August 2017

1 reference

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Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli

23 August 2017

1 reference

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IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines

23 August 2017

1 reference

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NF-kappaB: linking inflammation and immunity to cancer development and progression

23 August 2017

1 reference

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Characterisation of cell-penetrating peptide-mediated peptide delivery

23 August 2017

1 reference

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Negative regulation of toll-like receptor-mediated immune responses

23 August 2017

1 reference

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Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

23 August 2017

1 reference

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Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

23 August 2017

1 reference

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Therapeutics targeting the innate immune system

23 August 2017

1 reference

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The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

23 August 2017

1 reference

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Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL.

23 August 2017

1 reference

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Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta

23 August 2017

1 reference

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Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs

23 August 2017

1 reference

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TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

23 August 2017

1 reference

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LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF

23 August 2017

1 reference

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Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

23 August 2017

1 reference

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The Toll-IL-1 receptor adaptor family grows to five members.

23 August 2017

1 reference

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A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses

23 August 2017

1 reference

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Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

23 August 2017

1 reference

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Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

23 August 2017

1 reference

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Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis

23 August 2017

1 reference

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TIRAP: an adapter molecule in the Toll signaling pathway

23 August 2017

1 reference

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

23 August 2017

1 reference

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The evolution and genetics of innate immunity

23 August 2017

1 reference

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Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

23 August 2017

1 reference

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The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway

23 August 2017

1 reference

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Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages.

23 August 2017

1 reference

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Phylogenetic perspectives in innate immunity

23 August 2017

1 reference

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

23 August 2017

1 reference

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Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

23 August 2017

1 reference

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A family of human receptors structurally related to Drosophila Toll

23 August 2017

1 reference

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Molecular characterization and modular analysis of human MyD88

23 August 2017

1 reference

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Principles of protein-protein interactions

23 August 2017

1 reference

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Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex

23 August 2017

1 reference

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Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6

23 August 2017

1 reference

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Lead- and drug-like compounds: the rule-of-five revolution

23 August 2017

1 reference

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An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4.

6 September 2017

1 reference

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Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1beta signaling pathway

14 September 2017

1 reference

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TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages.

14 September 2017

1 reference

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Survival and cardiac remodeling after myocardial infarction are critically dependent on the host innate immune interleukin-1 receptor-associated kinase-4 signaling: a regulator of bone marrow-derived dendritic cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852602

Inhibition of tumor necrosis factor mRNA translation by a rationally designed immunomodulatory peptide

23 June 2018

1 reference

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Pharmacologic inhibition of myeloid differentiation factor 88 (MyD88) prevents left ventricular dilation and hypertrophy after experimental acute myocardial infarction in the mouse

23 June 2018

1 reference

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Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy.

1 September 2018

1 reference

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Identification of critical residues of the MyD88 death domain involved in the recruitment of downstream kinases

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852602

The TIR/BB-loop mimetic AS-1 protects the myocardium from ischaemia/reperfusion injury

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852602

Targeting of antigen to dendritic cells with poly(gamma-glutamic acid) nanoparticles induces antigen-specific humoral and cellular immunity

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852602

Cutting Edge: Differential inhibition of TLR signaling pathways by cell-permeable peptides representing BB loops of TLRs.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852602

The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852602

Essential function for the kinase TAK1 in innate and adaptive immune responses.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852602

RDP58 is a novel and potentially effective oral therapy for ulcerative colitis.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852602

Differential involvement of BB loops of toll-IL-1 resistance (TIR) domain-containing adapter proteins in TLR4- versus TLR2-mediated signal transduction.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852602

A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to Armadillo/beta-catenin that is conserved in mouse, Drosophila, and Caenorhabditis elegans.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852602

Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852602

Peptide-mediated interference of TIR domain dimerization in MyD88 inhibits interleukin-1-dependent activation of NF-{kappa}B

1 September 2018

1 reference

12 December 2020

Immune system's Toll-like receptors have good opportunity for cancer treatment

1 reference

12 December 2020

MyD88, IRAK1 and TRAF6 knockdown in human chondrocytes inhibits interleukin-1-induced matrix metalloproteinase-13 gene expression and promoter activity by impairing MAP kinase activation

1 reference

12 December 2020

Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes

1 reference

12 December 2020

Toll-like receptors and innate immunity

1 reference

12 December 2020

Unresponsiveness of MyD88-deficient mice to endotoxin

1 reference

12 December 2020

Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFkappaB activation pathways bifurcate at IL-1 receptor-associated kinase modification

1 reference

12 December 2020

1 reference

12 December 2020

Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88

1 reference

12 December 2020

Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound

1 reference

12 December 2020

Identifiers

DOI

10.1155/2010/674363

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20396389%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20396389%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

1 reference