The molecular mechanism of action of artemisinin--the debate continues. (Q37718570)

22 August 2017

2 references

28 May 2020

18 July 2021

The molecular mechanism of action of artemisinin--the debate continues (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6257357&resulttype=core&format=json

13 May 2020

0 references

1 reference

18 July 2021

Plasmodium falciparum

1 reference

18 July 2021

3

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13 May 2020

author name string

Paul M O'Neill

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6257357&resulttype=core&format=json

13 May 2020

Victoria E Barton

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6257357&resulttype=core&format=json

13 May 2020

language of work or name

English

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publication date

12 March 2010

3 references

22 August 2017

28 May 2020

18 July 2021

3 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6257357&resulttype=core&format=json

13 May 2020

28 May 2020

18 July 2021

15

1 reference

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13 May 2020

page(s)

1705-1721

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13 May 2020

issue

3

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Creative Commons Attribution

13 May 2020

copyright license

2 references

28 May 2020

18 July 2021

0 references

Oxidative stress response of tumor cells: microarray-based comparison between artemisinins and anthracyclines.

1 reference

12 December 2020

Identification of an antimalarial synthetic trioxolane drug development candidate

1 reference

12 December 2020

Molecular modes of action of artesunate in tumor cell lines.

1 reference

12 December 2020

The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin

1 reference

12 December 2020

Role of transferrin receptor and the ABC transporters ABCB6 and ABCB7 for resistance and differentiation of tumor cells towards artesunate

1 reference

12 December 2020

Stage-specific gametocytocidal effect in vitro of the antimalaria drug qinghaosu on Plasmodium falciparum

1 reference

12 December 2020

Alkylation of human albumin by the antimalarial artemisinin

1 reference

12 December 2020

The antimalarial drug artemisinin alkylates heme in infected mice

1 reference

12 December 2020

Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobin

1 reference

12 December 2020

Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron

1 reference

12 December 2020

Study on the mechanism of action of artemether against schistosomes: the identification of cysteine adducts of both carbon-centred free radicals derived from artemether

1 reference

12 December 2020

Digestive-vacuole genesis and endocytic processes in the early intraerythrocytic stages of Plasmodium falciparum

1 reference

12 December 2020

Docking studies of structurally diverse antimalarial drugs targeting PfATP6: no correlation between in silico binding affinity and in vitro antimalarial activity.

1 reference

12 December 2020

Desferrioxamine inhibits production of cytotoxic heme to protein cross-linked myoglobin: a mechanism to protect against oxidative stress without iron chelation

1 reference

12 December 2020

Artemisinin-derived sesquiterpene lactones as potential antitumour compounds: cytotoxic action against bone marrow and tumour cells

1 reference

12 December 2020

Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.

1 reference

12 December 2020

Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation

1 reference

12 December 2020

Artemisinin dimer anticancer activity correlates with heme-catalyzed reactive oxygen species generation and endoplasmic reticulum stress induction

1 reference

12 December 2020

A single amino acid residue can determine the sensitivity of SERCAs to artemisinins

1 reference

12 December 2020

Case report of a pituitary macroadenoma treated with artemether

1 reference

12 December 2020

Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent

1 reference

12 December 2020

Artesunate derived from traditional Chinese medicine induces DNA damage and repair.

1 reference

12 December 2020

Effect of artesunate on immune cells in ret-transgenic mouse melanoma model

1 reference

12 December 2020

Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu).

1 reference

12 December 2020

Artemisinins: their growing importance in medicine

1 reference

12 December 2020

EPR evidence for the involvement of free radicals in the iron-catalysed decomposition of qinghaosu (artemisinin) and some derivatives; antimalarial action of some polycyclic endoperoxides

1 reference

12 December 2020

New developments in synthetic peroxidic drugs as artemisinin mimics

1 reference

12 December 2020

Artemisinin, an Endoperoxide Antimalarial, Disrupts the Hemoglobin Catabolism and Heme Detoxification Systems in Malarial Parasite

1 reference

12 December 2020

Biomimetic Fe(II)-mediated degradation of arteflene (Ro-42-1611). The first EPR spin-trapping evidence for the previously postulated secondary carbon-centered cyclohexyl radical

1 reference

12 December 2020

Further evidence supporting the importance of and the restrictions on a carbon-centered radical for high antimalarial activity of 1,2,4-trioxanes like artemisinin

1 reference

12 December 2020

Alkylation of proteins by artemisinin. Effects of heme, pH, and drug structure

1 reference

12 December 2020

Different behavior of artemisinin and tetraoxane in the oxidative degradation of phospholipid.

1 reference

12 December 2020

In-vivo therapeutic efficacy trial with artemisinin derivative, buparvaquone and imidocarb dipropionate against Babesia equi infection in donkeys

1 reference

12 December 2020

The antimalarial trioxaquine DU1301 alkylates heme in malaria-infected mice.

1 reference

12 December 2020

Cytotoxicity of artemisinin-related endoperoxides to Ehrlich ascites tumor cells.

1 reference

12 December 2020

The structure of malaria pigment beta-haematin

1 reference

12 December 2020

Stereochemistry-dependent cytotoxicity of some artemisinin derivatives.

1 reference

12 December 2020

In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin

1 reference

12 December 2020

The Fe2+-mediated decomposition, PfATP6 binding, and antimalarial activities of artemisone and other artemisinins: the unlikelihood of C-centered radicals as bioactive intermediates.

1 reference

12 December 2020

Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to artemisinin: the importance of a carbon-centered radical for antimalarial activity

1 reference

12 December 2020

Recent advances in understanding the mechanism of hemozoin (malaria pigment) formation

1 reference

12 December 2020

Artemisinin and a Series of Novel Endoperoxide Antimalarials Exert Early Effects on Digestive Vacuole Morphology

1 reference

12 December 2020

Reaction of antimalarial endoperoxides with specific parasite proteins

1 reference

12 December 2020

Heme mediates cytotoxicity from artemisinin and serves as a general anti-proliferation target

1 reference

12 December 2020

Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase), tctp, mdr1, and cg10.

1 reference

12 December 2020

Plasmodium falciparum: in vitro studies of the pharmacodynamic properties of drugs used for the treatment of severe malaria

1 reference

12 December 2020

Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells

1 reference

12 December 2020

In vitro stage-specific sensitivity of Plasmodium falciparum to quinine and artemisinin drugs

1 reference

12 December 2020

Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277).

1 reference

12 December 2020

Synthesis and antimalarial activity of cyclic peroxides, 1,2,4,5, 7-pentoxocanes and 1,2,4,5-tetroxanes

1 reference

12 December 2020

The iron metabolism of neoplastic cells: alterations that facilitate proliferation?

1 reference

12 December 2020

1 reference

12 December 2020

Knowledge of the proposed chemical mechanism of action and cytochrome p450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides

1 reference

12 December 2020

Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells.

1 reference

12 December 2020

Yeast model uncovers dual roles of mitochondria in action of artemisinin

1 reference

12 December 2020

Artemisinins target the SERCA of Plasmodium falciparum

1 reference

12 December 2020

Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds

1 reference

12 December 2020

Three-dimensional structure of Plasmodium falciparum Ca2+ -ATPase(PfATP6) and docking of artemisinin derivatives to PfATP6.

1 reference

12 December 2020

Willmar Schwabe Award 2006: antiplasmodial and antitumor activity of artemisinin--from bench to bedside

1 reference

12 December 2020

Mechanistic perspectives for 1,2,4-trioxanes in anti-cancer therapy.

1 reference

12 December 2020

Stability of peroxide antimalarials in the presence of human hemoglobin

1 reference

12 December 2020

Iron chelators can protect against oxidative stress through ferryl heme reduction

1 reference

12 December 2020

Role of antioxidant genes for the activity of artesunate against tumor cells.

1 reference

12 December 2020

Relationship between antimalarial activity and heme alkylation for spiro- and dispiro-1,2,4-trioxolane antimalarials

1 reference

12 December 2020

Artemisinin (qinghaosu): the role of intracellular hemin in its mechanism of antimalarial action

1 reference

12 December 2020

10.3390/MOLECULES15031705

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6257357&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6257357&resulttype=core&format=json

13 May 2020

1 reference