A randomised, phase II trial of the DNA-hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in combination with carboplatin vs carboplatin alone in patients with recurrent, partially platinum-sensitive ovarian cancer. (Q37711644)

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scientific article published on 18 March 2014

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English	A randomised, phase II trial of the DNA-hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in combination with carboplatin vs carboplatin alone in patients with recurrent, partially platinum-sensitive ovarian cancer.	scientific article published on 18 March 2014

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scholarly article

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11 March 2020

A randomised, phase II trial of the DNA-hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in combination with carboplatin vs carboplatin alone in patients with recurrent, partially platinum-sensitive ovarian cancer (English)

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11 March 2020

phase II clinical trial

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based on heuristic

inferred from title

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based on heuristic

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based on heuristic

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Rosalind Glasspool

1

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author name string

R Brown

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M E Gore

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G J S Rustin

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R H Wilson

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11 March 2020

S Pledge

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J Paul

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11 March 2020

M Mackean

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11 March 2020

G D Hall

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11 March 2020

S E R Halford

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J Walker

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11 March 2020

K Appleton

14

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R Ullah

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S Kaye

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11 March 2020

Scottish Gynaecological Trials Group

17

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11 March 2020

language of work or name

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publication date

18 March 2014

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11 March 2020

British Journal of Cancer

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11 March 2020

110

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8

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11 March 2020

1923-1929

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11 March 2020

https://scigraph.springernature.com/pub.10.1038/bjc.2014.116

0 references

Epigenetic resensitization to platinum in ovarian cancer

1 reference

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23 August 2017

Therapeutic modulation of epigenetic drivers of drug resistance in ovarian cancer

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23 August 2017

Phase 1b-2a study to reverse platinum resistance through use of a hypomethylating agent, azacitidine, in patients with platinum-resistant or platinum-refractory epithelial ovarian cancer

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23 August 2017

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

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23 August 2017

A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer

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23 August 2017

The promises and pitfalls of epigenetic therapies in solid tumours

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23 August 2017

Methylation Linear Discriminant Analysis (MLDA) for identifying differentially methylated CpG islands

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23 August 2017

Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia

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23 August 2017

Epigenetics as a mechanism driving polygenic clinical drug resistance

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23 August 2017

The method of minimization for allocation to clinical trials. a review

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23 August 2017

Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling

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6 September 2017

Definitions for response and progression in ovarian cancer clinical trials incorporating RECIST 1.1 and CA 125 agreed by the Gynecological Cancer Intergroup (GCIG).

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6 September 2017

Identification of hypermethylated genes associated with cisplatin resistance in human cancers

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14 September 2017

A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer

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28 September 2017

hMLH1 expression and cellular responses of ovarian tumour cells to treatment with cytotoxic anticancer agents

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28 September 2017

DNA methylation and the expression of IL-4 and IFN-gamma promoter genes in patients with bronchial asthma.

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1 September 2018

Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors

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1 September 2018

Gemcitabine plus carboplatin compared with carboplatin in patients with platinum-sensitive recurrent ovarian cancer: an intergroup trial of the AGO-OVAR, the NCIC CTG, and the EORTC GCG.

1 reference

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1 September 2018

Prognostic DNA methylation biomarkers in ovarian cancer.

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1 September 2018

The acquisition of hMLH1 methylation in plasma DNA after chemotherapy predicts poor survival for ovarian cancer patients

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1 September 2018

Paclitaxel plus platinum-based chemotherapy versus conventional platinum-based chemotherapy in women with relapsed ovarian cancer: the ICON4/AGO-OVAR-2.2 trial.

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Reversal of drug resistance in human tumor xenografts by 2'-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter

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based on heuristic

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CpG Island Methylation of DNA Damage Response Genes in Advanced Ovarian Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/24642620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/BJC.2014.116

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11 March 2020

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11 March 2020

1 reference

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11 March 2020

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