Intracellular transduction using cell-penetrating peptides (Q37710990)

22 August 2017

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title

Intracellular transduction using cell-penetrating peptides (English)

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22 August 2017

Rupa Sawant

1

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22 August 2017

Vladimir Torchilin

series ordinal

2

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22 August 2017

publication date

21 December 2009

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22 August 2017

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22 August 2017

volume

6

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22 August 2017

issue

4

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22 August 2017

page(s)

628-640

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

22 August 2017

cites work

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Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis

21 January 2018

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Tat-mediated delivery of heterologous proteins into cells

21 January 2018

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The many ways to cross the plasma membrane.

21 January 2018

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Cell-penetrating peptides.

21 January 2018

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Cell-penetrating peptides: mechanism and kinetics of cargo delivery

21 January 2018

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VE-cadherin-derived cell-penetrating peptide, pVEC, with carrier functions.

21 January 2018

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Genetic engineering of proteins with cell membrane permeability

21 January 2018

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Cellular uptake of an alpha-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior non-endocytically

21 January 2018

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A new peptide vector for efficient delivery of oligonucleotides into mammalian cells.

21 January 2018

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Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery

21 January 2018

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Cargo delivery kinetics of cell-penetrating peptides

21 January 2018

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Multifaceted activities of the HIV-1 transactivator of transcription, Tat.

21 January 2018

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Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein

21 January 2018

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Cellular uptake of the tat protein from human immunodeficiency virus

21 January 2018

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Mutational analysis of a human immunodeficiency virus type 1 Tat protein transduction domain which is required for delivery of an exogenous protein into mammalian cells

21 January 2018

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Cellular delivery of impermeable effector molecules in the form of conjugates with peptides capable of mediating membrane translocation.

21 January 2018

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Cationic TAT peptide transduction domain enters cells by macropinocytosis.

21 January 2018

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Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake

21 January 2018

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Membrane transduction of oligoarginine in HeLa cells is not mediated by macropinocytosis

21 January 2018

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Molecular dynamics simulations suggest a mechanism for translocation of the HIV-1 TAT peptide across lipid membranes

21 January 2018

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Tat peptide-mediated cellular delivery: back to basics

21 January 2018

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Present and future of cell-penetrating peptide mediated delivery systems: "is the Trojan horse too wild to go only to Troy?".

21 January 2018

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The taming of the cell penetrating domain of the HIV Tat: myths and realities

21 January 2018

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Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent.

21 January 2018

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Interaction of antimicrobial dermaseptin and its fluorescently labeled analogues with phospholipid membranes

21 January 2018

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Mode of action of the antibacterial cecropin B2: a spectrofluorometric study.

21 January 2018

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Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives

21 January 2018

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Cell membrane lipid rafts mediate caveolar endocytosis of HIV-1 Tat fusion proteins

21 January 2018

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Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis.

21 January 2018

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Tat peptide-mediated intracellular delivery of pharmaceutical nanocarriers

21 January 2018

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TAT transduction: the molecular mechanism and therapeutic prospects

21 January 2018

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Antennapedia and HIV transactivator of transcription (TAT) "protein transduction domains" promote endocytosis of high molecular weight cargo upon binding to cell surface glycosaminoglycans.

21 January 2018

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Full-length proteins attached to the HIV tat protein transduction domain are neither transduced between cells, nor exhibit enhanced immunogenicity

21 January 2018

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Cell surface adherence and endocytosis of protein transduction domains.

21 January 2018

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Nuclear targeting of macromolecular polyanions by an HIV-Tat derived peptide. Role for cell-surface proteoglycans.

21 January 2018

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Evidence for a plasma membrane-mediated permeability barrier to Tat basic domain in well-differentiated epithelial cells: lack of correlation with heparan sulfate

21 January 2018

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Macropinocytosis: searching for an endocytic identity and role in the uptake of cell penetrating peptides

21 January 2018

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Temperature-, concentration- and cholesterol-dependent translocation of L- and D-octa-arginine across the plasma and nuclear membrane of CD34+ leukaemia cells.

21 January 2018

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Effects of cargo molecules on the cellular uptake of arginine-rich cell-penetrating peptides

21 January 2018

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Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement

21 January 2018

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Imaging and tracking of tat peptide-conjugated quantum dots in living cells: new insights into nanoparticle uptake, intracellular transport, and vesicle shedding.

21 January 2018

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Stability of cell-penetrating peptide-morpholino oligomer conjugates in human serum and in cells.

21 January 2018

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Cellular entry pathway and gene transfer capacity of TAT-modified lipoplexes.

21 January 2018

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A targeted protease substrate for a quantitative determination of protease activities in the endolysosomal pathway

21 January 2018

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Internalization of novel non-viral vector TAT-streptavidin into human cells

21 January 2018

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HIV-1 Tat protein transduction domain peptide facilitates gene transfer in combination with cationic liposomes.

21 January 2018

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Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery

21 January 2018

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Induction of splice correction by cell-penetrating peptide nucleic acids

21 January 2018

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Improved cytosolic translocation and tumor-killing activity of Tat-shepherdin conjugates mediated by co-treatment with Tat-fused endosome-disruptive HA2 peptide

21 January 2018

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Functionalized PEG-PEI copolymers complexed to exon-skipping oligonucleotides improve dystrophin expression in mdx mice

21 January 2018

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Gene delivery to differentiated neurotypic cells with RGD and HIV Tat peptide functionalized polymeric nanoparticles

21 January 2018

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Calcium ions effectively enhance the effect of antisense peptide nucleic acids conjugated to cationic tat and oligoarginine peptides

21 January 2018

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Enhanced delivery of cell-penetrating peptide-peptide nucleic acid conjugates by endosomal disruption

21 January 2018

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Asymmetric insertion of membrane proteins in lipid bilayers by solid-state NMR paramagnetic relaxation enhancement: a cell-penetrating Peptide example

21 January 2018

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Overcoming methotrexate resistance in breast cancer tumour cells by the use of a new cell-penetrating peptide

21 January 2018

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A non-covalent peptide-based strategy for protein and peptide nucleic acid transduction

21 January 2018

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Cell-penetrating peptides: mechanisms and applications

21 January 2018

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Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides

21 January 2018

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Cell-penetrating peptides as vectors for peptide, protein and oligonucleotide delivery

21 January 2018

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In vivo protein transduction: delivery of a biologically active protein into the mouse

21 January 2018

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Tat-mediated protein delivery can facilitate MHC class I presentation of antigens

21 January 2018

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Effect of cell-penetrating peptides on the nasal absorption of insulin

21 January 2018

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Usefulness of cell-penetrating peptides to improve intestinal insulin absorption

21 January 2018

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A peptide carrier for the delivery of biologically active proteins into mammalian cells.

21 January 2018

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Cellular penetration and nuclear importation properties of 111In-labeled and 123I-labeled HIV-1 tat peptide immunoconjugates in BT-474 human breast cancer cells

21 January 2018

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Different mechanisms for cellular internalization of the HIV-1 Tat-derived cell penetrating peptide and recombinant proteins fused to Tat.

21 January 2018

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Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation

21 January 2018

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TAT-Hsp70-mediated neuroprotection and increased survival of neuronal precursor cells after focal cerebral ischemia in mice

21 January 2018

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High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates.

21 January 2018

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Normal T-cell response and in vivo magnetic resonance imaging of T cells loaded with HIV transactivator-peptide-derived superparamagnetic nanoparticles

21 January 2018

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Superparamagnetic iron oxide particles transactivator protein-fluorescein isothiocyanate particle labeling for in vivo magnetic resonance imaging detection of cell migration: uptake and durability

21 January 2018

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Cellular trajectories of peptide-modified gold particle complexes: comparison of nuclear localization signals and peptide transduction domains

21 January 2018

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Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake.

21 January 2018

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Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells.

21 January 2018

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Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles.

21 January 2018

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Increased intracellular targeting to airway cells using octaarginine-coated liposomes: in vitro assessment of their suitability for inhalation

21 January 2018

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Nanostructured materials designed for cell binding and transduction

21 January 2018

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Peptide-derivatized shell-cross-linked nanoparticles. 1. Synthesis and characterization

21 January 2018

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Peptide-derivatized shell-cross-linked nanoparticles. 2. Biocompatibility evaluation

21 January 2018

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Rapid and effective labeling of brain tissue using TAT-conjugated CdS:Mn/ZnS quantum dots

21 January 2018

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Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo

21 January 2018

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Tat peptide as an efficient molecule to translocate gold nanoparticles into the cell nucleus.

21 January 2018

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Recent advances with liposomes as pharmaceutical carriers

21 January 2018

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p-Nitrophenylcarbonyl-PEG-PE-liposomes: fast and simple attachment of specific ligands, including monoclonal antibodies, to distal ends of PEG chains via p-nitrophenylcarbonyl groups

21 January 2018

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Structure and design of polymeric surfactant-based drug delivery systems

21 January 2018

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Micellar nanocarriers: pharmaceutical perspectives

21 January 2018

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Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review

21 January 2018

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Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect

21 January 2018

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Increased accumulation of PEG-PE micelles in the area of experimental myocardial infarction in rabbits

21 January 2018

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Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs

21 January 2018

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TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors

21 January 2018

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Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome-DNA complexes

21 January 2018

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OVCAR-3 cells internalize TAT-peptide modified liposomes by endocytosis

21 January 2018

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The architecture of ligand attachment to nanocarriers controls their specific interaction with target cells

21 January 2018

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Synthesis and evaluation of a novel lipid-peptide conjugate for functionalized liposome

21 January 2018

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siRNA-containing liposomes modified with polyarginine effectively silence the targeted gene

21 January 2018

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A biodegradable pH-sensitive micelle system for targeting acidic solid tumors

21 January 2018

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TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors

21 January 2018

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Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG-PEI.

21 January 2018

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Functionalization and cellular uptake of boron carbide nanoparticles. The first step toward T cell-guided boron neutron capture therapy.

21 January 2018

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Application of novel solid lipid nanoparticle (SLN)-gene vector formulations based on a dimeric HIV-1 TAT-peptide in vitro and in vivo.

21 January 2018

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Thiocholesterol-based lipids for ordered assembly of bioresponsive gene carriers

21 January 2018

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Effects of cell-penetrating peptides and pegylation on transfection efficiency of polyethylenimine in mouse lungs

21 January 2018

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Intracellular delivery of oligonucleotide conjugates and dendrimer complexes

21 January 2018

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Improved transfection of spleen-derived antigen-presenting cells in culture using TATp-liposomes

21 January 2018

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Gene delivery into ischemic myocardium by double-targeted lipoplexes with anti-myosin antibody and TAT peptide

21 January 2018

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Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides

21 January 2018

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Enhancing the cellular uptake of siRNA duplexes following noncovalent packaging with protein transduction domain peptides

21 January 2018

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Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells.

21 January 2018

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Delivery of short interfering RNA using endosomolytic cell-penetrating peptides.

21 January 2018

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Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity.

21 January 2018

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Cell-penetrating-peptide-mediated siRNA lung delivery

21 January 2018

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Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation.

21 January 2018

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Efficient splicing correction by PNA conjugation to an R6-Penetratin delivery peptide

21 January 2018

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Complexes of plasmid DNA with basic domain 47-57 of the HIV-1 Tat protein are transferred to mammalian cells by endocytosis-mediated pathways.

21 January 2018

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Evaluation of transportan 10 in PEI mediated plasmid delivery assay

21 January 2018

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Tumor imaging by means of proteolytic activation of cell-penetrating peptides

21 January 2018

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Synthesis and characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis.

21 January 2018

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Biochemical and in vivo characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis

21 January 2018

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Quantum dot bioconjugates for imaging, labelling and sensing

21 January 2018

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Noninvasive imaging of quantum dots in mice

21 January 2018

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Photoactivation of quantum dot fluorescence following endocytosis

21 January 2018

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Self-assembled quantum dot-peptide bioconjugates for selective intracellular delivery

21 January 2018

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Cellular internalization and targeting of semiconductor quantum dots.

21 January 2018

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Characterization of novel histidine-tagged Tat-peptide complexes dual-labeled with (99m)Tc-tricarbonyl and fluorescein for scintigraphy and fluorescence microscopy

21 January 2018

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Site-specific conjugation of HIV-1 tat peptides to IgG: a potential route to construct radioimmunoconjugates for targeting intracellular and nuclear epitopes in cancer

21 January 2018

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HIV-1 Tat peptide immunoconjugates differentially sensitize breast cancer cells to selected antiproliferative agents that induce the cyclin-dependent kinase inhibitor p21WAF-1/CIP-1.

21 January 2018

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Application of cell penetrating peptide in magnetic resonance imaging of bone marrow mesenchymal stem cells.

21 January 2018

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Cellular delivery of MRI contrast agents

21 January 2018

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Macrocyclic chelators with paramagnetic cations are internalized into mammalian cells via a HIV-tat derived membrane translocation peptide.

21 January 2018

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Targeted polymeric micelles for delivery of poorly soluble drugs

21 January 2018

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Recent advances in tumor-targeting anticancer drug conjugates.

21 January 2018

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Tumor cell targeting of liposome-entrapped drugs with phospholipid-anchored folic acid-PEG conjugates

21 January 2018

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Mechanisms of TfR-mediated transcytosis and sorting in epithelial cells and applications toward drug delivery

21 January 2018

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"SMART" drug delivery systems: double-targeted pH-responsive pharmaceutical nanocarriers

21 January 2018

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Design, synthesis, and characterization of pH-sensitive PEG-PE conjugates for stimuli-sensitive pharmaceutical nanocarriers: the effect of substitutes at the hydrazone linkage on the ph stability of PEG-PE conjugates

21 January 2018

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Enhanced transfection of tumor cells in vivo using "Smart" pH-sensitive TAT-modified pegylated liposomes

21 January 2018

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A Comprehensive Model for the Cellular Uptake of Cationic Cell-penetrating Peptides

21 January 2018

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Cell-penetrating peptides—A brief introduction

21 January 2018

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A Novel Cell-penetrating Peptide, M918, for Efficient Delivery of Proteins and Peptide Nucleic Acids

21 January 2018

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Visualizing a Correlation between siRNA Localization, Cellular Uptake, and RNAi in Living Cells

21 January 2018

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Uptake and Intracellular Fate of Surface-Modified Gold Nanoparticles

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/B916297F

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22 August 2017

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