Methodological challenges in mendelian randomization (Q37694967)

22 August 2017

Methodological challenges in mendelian randomization (English)

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22 August 2017

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Tyler J VanderWeele

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PMCID

3981897

22 August 2017

Eric Tchetgen Tchetgen

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2

object named as

Eric J Tchetgen Tchetgen

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22 August 2017

Marilyn Cornelis

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1 reference

PMCID

3981897

22 August 2017

Peter Kraft

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22 August 2017

1 May 2014

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22 August 2017

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22 August 2017

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22 August 2017

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22 August 2017

427-435

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Genome-wide association studies identify four ER negative-specific breast cancer risk loci

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Commentary: building an evidence base for mendelian randomization studies: assessing the validity and strength of proposed genetic instrumental variables

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Pancreatic beta-cell function and type 2 diabetes risk: quantify the causal effect using a Mendelian randomization approach based on meta-analyses

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Genetic variants on 15q25.1, smoking, and lung cancer: an assessment of mediation and interaction

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Mendelian randomization analysis of case-control data using structural mean models

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Bias formulas for sensitivity analysis of unmeasured confounding for general outcomes, treatments, and confounders

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Odds ratios for mediation analysis for a dichotomous outcome

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Hundreds of variants clustered in genomic loci and biological pathways affect human height

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Sex hormone-binding globulin and risk of type 2 diabetes in women and men

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Mendelian randomization as an instrumental variable approach to causal inference

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Mendelian randomization: prospects, potentials, and limitations

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Identifiability and exchangeability for direct and indirect effects

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Credible Mendelian randomization studies: approaches for evaluating the instrumental variable assumptions

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

The effect of non-differential measurement error on bias, precision and power in Mendelian randomization studies

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Apolipoprotein E isoforms, serum cholesterol, and cancer.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Severity of bias of a simple estimator of the causal odds ratio in Mendelian randomization studies.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Adjusting for bias and unmeasured confounding in Mendelian randomization studies with binary responses

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

C-reactive protein and its role in metabolic syndrome: mendelian randomisation study

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Meta-analysis of genetic studies using Mendelian randomization--a multivariate approach

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Homocysteine and stroke: evidence on a causal link from mendelian randomisation

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Commentary: the concept of 'Mendelian Randomization'.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Re: "Credible Mendelian Randomization Studies: Approaches For Evaluating The Instrumental Variable Assumptions"

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981897

Extended instrumental variables estimation for overall effects

3 December 2018

1 reference

12 December 2020

Re: "Credible Mendelian Randomization Studies: Approaches For Evaluating The Instrumental Variable Assumptions"

1 reference

12 December 2020

Mendelian randomisation: a new spin or real progress?

1 reference

12 December 2020

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

1 reference

12 December 2020

10.1097/EDE.0000000000000081

Identifiers

DOI

1 reference

22 August 2017

1 reference

22 August 2017

1 reference

PMCID

3981897