Aurora kinase inhibitors: novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemias. (Q37690579)

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18 January 2020

review article

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title

Aurora kinase inhibitors: novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemias (English)

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18 January 2020

1

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18 January 2020

Spiros Linardopoulos

series ordinal

3

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18 January 2020

author name string

J Blagg

series ordinal

2

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18 January 2020

A D J Pearson

series ordinal

4

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18 January 2020

publication date

11 February 2010

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18 January 2020

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18 January 2020

volume

24

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18 January 2020

issue

4

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18 January 2020

page(s)

671-678

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https://scigraph.springernature.com/pub.10.1038/leu.2010.15

18 January 2020

exact match

0 references

cites work

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Aurora kinase inhibitory VX-680 increases Bax/Bcl-2 ratio and induces apoptosis in Aurora-A-high acute myeloid leukemia

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Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts

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Sequential ABL kinase inhibitor therapy selects for compound drug-resistant BCR-ABL mutations with altered oncogenic potency

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Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I.

21 January 2018

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Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia

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Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen

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KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation.

21 January 2018

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Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

21 January 2018

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AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo

21 January 2018

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AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis

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VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

21 January 2018

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21 January 2018

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21 January 2018

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MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation

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7 January 2021

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Therapeutic potential of JAK2 inhibitors

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https://api.crossref.org/works/10.1038%2FLEU.2010.15

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7 January 2021

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Identifiers

DOI

10.1038/LEU.2010.15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20147976%20AND%20SRC:MED&resulttype=core&format=json

release_un55fdwltfgvbgsacgcixlcar4

18 January 2020

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24 November 2022

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