Towards a unifying mechanism for ClpB/Hsp104-mediated protein disaggregation and prion propagation (Q37687105)

22 August 2017

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title

Towards a unifying mechanism for ClpB/Hsp104-mediated protein disaggregation and prion propagation (English)

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22 August 2017

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2

Bernd Bukau

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22 August 2017

3

Axel Mogk

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22 August 2017

1

Tobias Haslberger

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22 August 2017

1 February 2010

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Biochemistry and Cell Biology

22 August 2017

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22 August 2017

88

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22 August 2017

1

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22 August 2017

63-75

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Hsp104 interacts with Hsp90 cochaperones in respiring yeast

22 August 2017

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Asymmetric inheritance of oxidatively damaged proteins during cytokinesis

21 January 2018

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A systematic survey identifies prions and illuminates sequence features of prionogenic proteins

21 January 2018

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Variant-specific [PSI+] infection is transmitted by Sup35 polymers within [PSI+] aggregates with heterogeneous protein composition

21 January 2018

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The amino-terminal domain of ClpB supports binding to strongly aggregated proteins

21 January 2018

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Substrate binding to the molecular chaperone Hsp104 and its regulation by nucleotides

21 January 2018

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Effects of protein stability and structure on substrate processing by the ClpXP unfolding and degradation machine

21 January 2018

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clpB, a novel member of the Listeria monocytogenes CtsR regulon, is involved in virulence but not in general stress tolerance

21 January 2018

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Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+]

21 January 2018

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The N-terminal domain of Escherichia coli ClpB enhances chaperone function.

21 January 2018

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Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains

21 January 2018

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Size-dependent disaggregation of stable protein aggregates by the DnaK chaperone machinery.

21 January 2018

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Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity

21 January 2018

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Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae

21 January 2018

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Translation termination efficiency can be regulated in Saccharomyces cerevisiae by environmental stress through a prion-mediated mechanism

21 January 2018

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Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p

21 January 2018

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Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins

21 January 2018

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Self-seeded fibers formed by Sup35, the protein determinant of [PSI+], a heritable prion-like factor of S. cerevisiae.

21 January 2018

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Modulation of prion-dependent polyglutamine aggregation and toxicity by chaperone proteins in the yeast model.

21 January 2018

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Sequential mechanism of solubilization and refolding of stable protein aggregates by a bichaperone network

21 January 2018

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M domains couple the ClpB threading motor with the DnaK chaperone activity.

21 January 2018

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Protein disaggregation by the AAA+ chaperone ClpB involves partial threading of looped polypeptide segments.

21 January 2018

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Cooperative kinetics of both Hsp104 ATPase domains and interdomain communication revealed by AAA sensor-1 mutants

21 January 2018

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Specificity of the J-protein Sis1 in the propagation of 3 yeast prions

21 January 2018

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Loops in the central channel of ClpA chaperone mediate protein binding, unfolding, and translocation

21 January 2018

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ClpAP and ClpXP degrade proteins with tags located in the interior of the primary sequence

21 January 2018

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N-terminal domain of yeast Hsp104 chaperone is dispensable for thermotolerance and prion propagation but necessary for curing prions by Hsp104 overexpression

21 January 2018

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The crystal structure of murine p97/VCP at 3.6A

21 January 2018

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Hsp104 binds to yeast Sup35 prion fiber but needs other factor(s) to sever it.

21 January 2018

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The N-terminal substrate-binding domain of ClpA unfoldase is highly mobile and extends axially from the distal surface of ClpAP protease

21 January 2018

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Amino acid residue 184 of yeast Hsp104 chaperone is critical for prion-curing by guanidine, prion propagation, and thermotolerance

21 January 2018

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Misfolded proteins partition between two distinct quality control compartments

21 January 2018

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Structure and function of the middle domain of ClpB from Escherichia coli

21 January 2018

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Molecular determinants of complex formation between Clp/Hsp100 ATPases and the ClpP peptidase.

21 January 2018

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A novel role for 100 kD heat shock proteins in the parasite Leishmania donovani

21 January 2018

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Concurrent translocation of multiple polypeptide chains through the proteasomal degradation channel

21 January 2018

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The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state

21 January 2018

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Visualizing the ATPase cycle in a protein disaggregating machine: structural basis for substrate binding by ClpB

21 January 2018

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Conformational properties of aggregated polypeptides determine ClpB-dependence in the disaggregation process.

21 January 2018

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Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

21 January 2018

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Evidence for an unfolding/threading mechanism for protein disaggregation by Saccharomyces cerevisiae Hsp104.

21 January 2018

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Peptide and protein binding in the axial channel of Hsp104. Insights into the mechanism of protein unfolding

21 January 2018

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Diverse pore loops of the AAA+ ClpX machine mediate unassisted and adaptor-dependent recognition of ssrA-tagged substrates.

21 January 2018

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The heat-shock protein ClpB of Francisella tularensis is involved in stress tolerance and is required for multiplication in target organs of infected mice.

21 January 2018

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Identification of thermolabile Escherichia coli proteins: prevention and reversion of aggregation by DnaK and ClpB.

21 January 2018

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Roles of individual domains and conserved motifs of the AAA+ chaperone ClpB in oligomerization, ATP hydrolysis, and chaperone activity

21 January 2018

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[URE3] prion propagation in Saccharomyces cerevisiae: requirement for chaperone Hsp104 and curing by overexpressed chaperone Ydj1p

21 January 2018

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Heat-inactivated proteins are rescued by the DnaK.J-GrpE set and ClpB chaperones

21 January 2018

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An Arabidopsis chloroplast-targeted Hsp101 homologue, APG6, has an essential role in chloroplast development as well as heat-stress response.

21 January 2018

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Walker-A threonine couples nucleotide occupancy with the chaperone activity of the AAA+ ATPase ClpB.

21 January 2018

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RETRACTED: A prion of yeast metacaspase homolog (Mca1p) detected by a genetic screen

21 January 2018

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Antagonistic interactions between yeast chaperones Hsp104 and Hsp70 in prion curing

21 January 2018

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AAA+ superfamily ATPases: common structure--diverse function

21 January 2018

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Protein disaggregation mediated by heat-shock protein Hsp104.

21 January 2018

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The yeast global transcriptional co-repressor protein Cyc8 can propagate as a prion

21 January 2018

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Heat shock protein 101 plays a crucial role in thermotolerance in Arabidopsis.

21 January 2018

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HSP104 required for induced thermotolerance

21 January 2018

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Hsp104-dependent remodeling of prion complexes mediates protein-only inheritance

21 January 2018

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Dominant gain-of-function mutations in Hsp104p reveal crucial roles for the middle region

21 January 2018

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A chaperone network for the resolubilization of protein aggregates: direct interaction of ClpB and DnaK.

21 January 2018

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Solubilization of aggregated proteins by ClpB/DnaK relies on the continuous extraction of unfolded polypeptides

21 January 2018

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Substrate recognition by the AAA+ chaperone ClpB.

21 January 2018

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Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers

21 January 2018

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Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities

21 January 2018

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Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions

21 January 2018

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Role of the processing pore of the ClpX AAA+ ATPase in the recognition and engagement of specific protein substrates

21 January 2018

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The E. coli dnaK gene product, the hsp70 homolog, can reactivate heat-inactivated RNA polymerase in an ATP hydrolysis-dependent manner

21 January 2018

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The AAA+ superfamily of functionally diverse proteins

21 January 2018

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The role of Sis1 in the maintenance of the [RNQ+] prion

21 January 2018

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ClpB is the Escherichia coli heat shock protein F84.1.

21 January 2018

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Substrate threading through the central pore of the Hsp104 chaperone as a common mechanism for protein disaggregation and prion propagation

21 January 2018

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The yeast AAA+ chaperone Hsp104 is part of a network that links the actin cytoskeleton with the inheritance of damaged proteins

21 January 2018

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In vivo monitoring of the prion replication cycle reveals a critical role for Sis1 in delivering substrates to Hsp104

21 January 2018

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A yeast prion provides a mechanism for genetic variation and phenotypic diversity

21 January 2018

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Prion switching in response to environmental stress

21 January 2018

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ATP binding to nucleotide binding domain (NBD)1 of the ClpB chaperone induces motion of the long coiled-coil, stabilizes the hexamer, and activates NBD2.

21 January 2018

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Stability of the two wings of the coiled-coil domain of ClpB chaperone is critical for its disaggregation activity

21 January 2018

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Mechanism of prion loss after Hsp104 inactivation in yeast

21 January 2018

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Characterization of a trap mutant of the AAA+ chaperone ClpB.

21 January 2018

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Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB.

21 January 2018

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Atypical AAA+ subunit packing creates an expanded cavity for disaggregation by the protein-remodeling factor Hsp104.

21 January 2018

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Motor mechanism for protein threading through Hsp104.

21 January 2018

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Coupling and dynamics of subunits in the hexameric AAA+ chaperone ClpB.

21 January 2018

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Conserved Pore Residues in the AAA Protease FtsH Are Important for Proteolysis and Its Coupling to ATP Hydrolysis

21 January 2018

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The Porphyromonas gingivalis clpB gene is involved in cellular invasion in vitro and virulence in vivo

21 January 2018

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Successive and synergistic action of the Hsp70 and Hsp100 chaperones in protein disaggregation

21 January 2018

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Hsp70 chaperone machine remodels protein aggregates at the initial step of Hsp70-Hsp100-dependent disaggregation.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/O09-118

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22 August 2017

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PubMed ID

20130680