Antimicrobial nucleoside antibiotics targeting cell wall assembly: recent advances in structure-function studies and nucleoside biosynthesis (Q37683527)

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scientific article published on 16 December 2009

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English	Antimicrobial nucleoside antibiotics targeting cell wall assembly: recent advances in structure-function studies and nucleoside biosynthesis	scientific article published on 16 December 2009

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scholarly article

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Europe PubMed Central

22 August 2017

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Europe PubMed Central

Antimicrobial nucleoside antibiotics targeting cell wall assembly: recent advances in structure-function studies and nucleoside biosynthesis (English)

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Europe PubMed Central

22 August 2017

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based on heuristic

inferred from title

2

object named as

Rebecca J M Goss

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author name string

Michael Winn

1

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Europe PubMed Central

22 August 2017

Rebecca J M Goss

2

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Europe PubMed Central

22 August 2017

Ken-ichi Kimura

3

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Europe PubMed Central

22 August 2017

Timothy D H Bugg

4

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Europe PubMed Central

22 August 2017

publication date

16 December 2009

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Europe PubMed Central

22 August 2017

Natural Product Reports

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Europe PubMed Central

22 August 2017

27

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Europe PubMed Central

22 August 2017

2

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Europe PubMed Central

22 August 2017

279-304

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Europe PubMed Central

22 August 2017

Antibacterial discovery and development--the failure of success?

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Drugs for bad bugs: confronting the challenges of antibacterial discovery

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Why is big Pharma getting out of antibacterial drug discovery?

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Recent advances in antimicrobial nucleoside antibiotics targeting cell wall biosynthesis

1 reference

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21 January 2018

Intracellular steps of bacterial cell wall peptidoglycan biosynthesis: enzymology, antibiotics, and antibiotic resistance

1 reference

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Recent advances in the formation of the bacterial peptidoglycan monomer unit

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The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis

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The biosynthesis of peptidoglycan lipid-linked intermediates

1 reference

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In vitro assembly of a complete, pentaglycine interpeptide bridge containing cell wall precursor (lipid II-Gly5) of Staphylococcus aureus

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21 January 2018

Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan

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Chemistry and biology of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity

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Glycopeptide and lipoglycopeptide antibiotics

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Modeling bacterial UDP-HexNAc: polyprenol-P HexNAc-1-P transferases

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Topological analysis of the MraY protein catalysing the first membrane step of peptidoglycan synthesis.

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Purification and characterization of the bacterial MraY translocase catalyzing the first membrane step of peptidoglycan biosynthesis

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Phospho-N-acetyl-muramyl-pentapeptide translocase from Escherichia coli: catalytic role of conserved aspartic acid residues

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Active site mapping of MraY, a member of the polyprenyl-phosphate N-acetylhexosamine 1-phosphate transferase superfamily, catalyzing the first membrane step of peptidoglycan biosynthesis

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Genetic evidence that the bacteriophage phi X174 lysis protein inhibits cell wall synthesis

1 reference

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The lysis protein E of phi X174 is a specific inhibitor of the MraY-catalyzed step in peptidoglycan synthesis.

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Interaction of the transmembrane domain of lysis protein E from bacteriophage phiX174 with bacterial translocase MraY and peptidyl-prolyl isomerase SlyD.

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Purification and functional characterization of phiX174 lysis protein E.

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The cell wall: a carbohydrate armour for the fungal cell

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Cell wall assembly in Saccharomyces cerevisiae

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Antibiotic resistance versus small molecules, the chemical evolution

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Stereochemical elucidation and total synthesis of dihydropacidamycin D, a semisynthetic pacidamycin

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Synthesis of base-modified dihydropacidamycins

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Synthetic dihydropacidamycin antibiotics: a modified spectrum of activity for the pacidamycin class

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New pacidamycin antibiotics through precursor-directed biosynthesis

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Sansanmycins B and C, new components of sansanmycins.

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Synthesis and activity of 5'-uridinyl dipeptide analogues mimicking the amino terminal peptide chain of nucleoside antibiotic mureidomycin A.

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21 January 2018

A solid-phase approach to analogues of the antibiotic mureidomycin

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Solid-phase synthesis and biological evaluation of a uridinyl branched peptide urea library

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Caprazamycins, novel lipo-nucleoside antibiotics, from Streptomyces sp. II. Structure elucidation of caprazamycins

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21 January 2018

Fine synthetic nucleoside chemistry based on nucleoside natural products synthesis.

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Identification and manipulation of the caprazamycin gene cluster lead to new simplified liponucleoside antibiotics and give insights into the biosynthetic pathway

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21 January 2018

Assignment of the liposidomycin diazepanone stereochemistry.

1 reference

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Synthesis of the nucleoside moiety of liposidomycins: elucidation of the pharmacophore of this family of MraY inhibitors

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Synthesis of analogues of the O-beta-D-ribofuranosyl nucleoside moiety of liposidomycins. Part 1: contribution of the amino group and the uracil moiety upon the inhibition of MraY.

1 reference

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Synthesis of analogues of the O-beta-D-ribofuranosyl nucleoside moiety of liposidomycins. Part 2: role of the hydroxyl groups upon the inhibition of MraY.

1 reference

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Synthesis of sub-micromolar inhibitors of MraY by exploring the region originally occupied by the diazepanone ring in the liposidomycin structure

1 reference

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Total synthesis of caprazol, a core structure of the caprazamycin antituberculosis antibiotics

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Development of a highly beta-selective ribosylation reaction without using neighboring group participation: total synthesis of (+)-caprazol, a core structure of caprazamycins

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Design and synthesis of diketopiperazine and acyclic analogs related to the caprazamycins and liposidomycins as potential antibacterial agents.

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Structure-activity relationship of truncated analogs of caprazamycins as potential anti-tuberculosis agents

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Synthesis of caprazamycin analogues and their structure--activity relationship for antibacterial activity.

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Synthesis and antimycobacterial activity of capuramycin analogues. Part 1: substitution of the azepan-2-one moiety of capuramycin

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Synthesis and antimycobacterial activity of capuramycin analogues. Part 2: acylated derivatives of capuramycin-related compounds

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Activity of capuramycin analogues against Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium intracellulare in vitro and in vivo

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In vitro antimycobacterial activities of capuramycin analogues

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Conformational analysis of chirally deuterated tunicamycin as an active site probe of UDP-N-acetylhexosamine:polyprenol-P N-acetylhexosamine-1-P translocases

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Novel inhibitory action of tunicamycin homologues suggests a role for dynamic protein fatty acylation in growth cone-mediated neurite extension

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Structures of the muraymycins, novel peptidoglycan biosynthesis inhibitors

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Muraymycins, novel peptidoglycan biosynthesis inhibitors: semisynthesis and SAR of their derivatives

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Muraymycins, novel peptidoglycan biosynthesis inhibitors: synthesis and SAR of their analogues

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Metabolic products of microorganisms 181. Chitin synthase from fungi, a test model for substances with insecticidal properties

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Recent advances in antifungal agents

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Cloning and heterologous expression of the entire set of structural genes for nikkomycin synthesis from Streptomyces tendae Tü901 in Streptomyces lividans

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Cloning, sequencing, and function of sanF: A gene involved in nikkomycin biosynthesis of Streptomyces ansochromogenes

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Molecular characterization of co-transcribed genes from Streptomyces tendae Tü901 involved in the biosynthesis of the peptidyl moiety and assembly of the peptidyl nucleoside antibiotic nikkomycin

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The Streptomyces tendae Tü901 L-lysine 2-aminotransferase catalyzes the initial reaction in nikkomycin D biosynthesis.

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Nikkomycin biosynthesis: formation of a 4-electron oxidation product during turnover of NikD with its physiological substrate

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A mobile tryptophan is the intrinsic charge transfer donor in a flavoenzyme essential for nikkomycin antibiotic biosynthesis

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SanJ, an ATP-dependent picolinate-CoA ligase, catalyzes the conversion of picolinate to picolinate-CoA during nikkomycin biosynthesis in Streptomyces ansochromogenes.

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Identification and characterization of sanH and sanI involved in the hydroxylation of pyridyl residue during nikkomycin biosynthesis in Streptomyces ansochromogenes

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SanT, a bidomain protein, is essential for nikkomycin biosynthesis of Streptomyces ansochromogenes.

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Formation of beta-hydroxy histidine in the biosynthesis of nikkomycin antibiotics

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Identifiers

10.1039/B816215H

1 reference

Europe PubMed Central

22 August 2017

1 reference

Europe PubMed Central

22 August 2017

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