Phospholipase A2 inhibitors as potential therapeutic agents for the treatment of inflammatory diseases. (Q37658843)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20021282%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

review article

1 reference

title

Phospholipase A2 inhibitors as potential therapeutic agents for the treatment of inflammatory diseases (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20021282%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20021282%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

author name string

George Kokotos

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20021282%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

language of work or name

English

0 references

publication date

1 January 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20021282%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Therapeutic Patents

15 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20021282%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

volume

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20021282%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

page(s)

1-18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20021282%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20021282%20AND%20SRC:MED&resulttype=core&format=json

Phospholipase A2 structure/function, mechanism, and signaling

15 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Phospholipase A2 biochemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Prostaglandins and leukotrienes: advances in eicosanoid biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

The phospholipase A2 superfamily and its group numbering system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Inhibitors of secretory phospholipase A2 group IIA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Various secretory phospholipase A2 enzymes are expressed in rheumatoid arthritis and augment prostaglandin production in cultured synovial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Interfacial enzymology: the secreted phospholipase A(2)-paradigm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Biochemistry and physiology of mammalian secreted phospholipases A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Biology of secretory phospholipase A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Secretory phospholipase A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Group V sPLA2: classical and novel functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Distinctiveness of secretory phospholipase A2 group IIA and V suggesting unique roles in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Potent modification of low density lipoprotein by group X secretory phospholipase A2 is linked to macrophage foam cell formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Group V sPLA2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Group v secretory phospholipase A2 promotes atherosclerosis: evidence from genetically altered mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Diverse cellular localizations of secretory phospholipase A2 enzymes in several human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Increasing molecular diversity of secreted phospholipases A(2) and their receptors and binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Both group IB and group IIA secreted phospholipases A2 are natural ligands of the mouse 180-kDa M-type receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Recombinant production and properties of binding of the full set of mouse secreted phospholipases A2 to the mouse M-type receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Properties of the Group IV phospholipase A2 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Functional identification of the active-site nucleophile of the human 85-kDa cytosolic phospholipase A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Acute lung injury by sepsis and acid aspiration: a key role for cytosolic phospholipase A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Cytosolic phospholipase A2-alpha: a potential therapeutic target for prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Cellular regulation and proposed biological functions of group VIA calcium-independent phospholipase A2 in activated cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Calcium-independent phospholipase A2 and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Role of Ca2+-independent phospholipase A2 in cell growth and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Group VI phospholipases A2: homeostatic phospholipases with significant potential as targets for novel therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Male mice that do not express group VIA phospholipase A2 produce spermatozoa with impaired motility and have greatly reduced fertility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Biology of platelet-activating factor acetylhydrolase (PAF-AH, lipoprotein associated phospholipase A2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Plasma platelet-activating factor acetylhydrolase is a secreted phospholipase A2 with a catalytic triad

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Anti-inflammatory properties of a platelet-activating factor acetylhydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Role of lipoprotein-associated phospholipase A2 in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Lipoprotein-associated phospholipase A2: a risk marker or a risk factor?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Future role for selective phospholipase A2 inhibitors in the prevention of atherosclerotic cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Lipoprotein-associated and secretory phospholipase A2 in cardiovascular disease: the epidemiological evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Inhibition of cytosolic phospholipase A2alpha: hit to lead optimization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2alpha: optimization of in vitro potency and rat pharmacokinetics for oral efficacy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Blockade of cytosolic phospholipase A2 alpha prevents experimental autoimmune encephalomyelitis and diminishes development of Th1 and Th17 responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Reactions of functionalized sulfonamides: application to lowering the lipophilicity of cytosolic phospholipase A2alpha inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Benzhydrylquinazolinediones: novel cytosolic phospholipase A2alpha inhibitors with improved physicochemical properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

1-(5-Carboxyindol-1-yl)propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: synthesis and properties of bioisosteric benzimidazole, benzotriazole and indazole analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Inhibition of group IVA cytosolic phospholipase A2 by novel 2-oxoamides in vitro, in cells, and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Differential inhibition of group IVA and group VIA phospholipases A2 by 2-oxoamides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Structure-activity relationship of 2-oxoamide inhibition of group IVA cytosolic phospholipase A2 and group V secreted phospholipase A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

2-Oxoamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudodipeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Pyrrolidine inhibitors of human cytosolic phospholipase A(2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Inhibitory effect of a potent and selective cytosolic phospholipase A2alpha inhibitor RSC-3388 on skin inflammation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Synthesis of medicinally interesting polyfluoro ketones via perfluoroalkyl lithium reagents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Intracellular phospholipase A(2) group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

The effect of darapladib on plasma lipoprotein-associated phospholipase A2 activity and cardiovascular biomarkers in patients with stable coronary heart disease or coronary heart disease risk equivalent: the results of a multicenter, randomized, dou

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Effects of the direct lipoprotein-associated phospholipase A(2) inhibitor darapladib on human coronary atherosclerotic plaque

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

The role of lipoprotein-associated phospholipase A2 on cardiovascular disease risk assessment and plaque rupture: a clinical review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Phospholipase A2 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Inhibition of cyclooxygenases 1 and 2 by the phospholipase-blocker, arachidonyl trifluoromethyl ketone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Bromoenol lactone inhibits magnesium-dependent phosphatidate phosphohydrolase and blocks triacylglycerol biosynthesis in mouse P388D1 macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Function and inhibition of intracellular calcium-independent phospholipase A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

A bromoenol lactone suicide substrate inactivates group VIA phospholipase A2 by generating a diffusible bromomethyl keto acid that alkylates cysteine thiols

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Antibacterial actions of secreted phospholipases A2. Review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Phospholipase A2 as targets for anti-cancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

21 January 2018

Phospholipase A2 enzymes

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Trifluoromethyl ketones and methyl fluorophosphonates as inhibitors of group IV and VI phospholipases A2: structure-function studies with vesicle, micelle, and membrane assays1This paper is dedicated to the memory of Prof. H.M. Verheij.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

Role of cytosolic phospholipase A2 in allergic response and parturition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903463905

10.1517/13543770903463905

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20021282%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference