AICAR positively regulate glycogen synthase activity and LDL receptor expression through Raf-1/MEK/p42/44MAPK/p90RSK/GSK-3 signaling cascade (Q37645697)

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scientific article published on September 2007

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English	AICAR positively regulate glycogen synthase activity and LDL receptor expression through Raf-1/MEK/p42/44MAPK/p90RSK/GSK-3 signaling cascade	scientific article published on September 2007

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

AICAR positively regulate glycogen synthase activity and LDL receptor expression through Raf-1/MEK/p42/44MAPK/p90RSK/GSK-3 signaling cascade (English)

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

author name string

Hsiang-Ming Wang

1

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Sonya Mehta

2

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Rishipal Bansode

3

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Wei Huang

4

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Europe PubMed Central

PMC publication ID

21 August 2017

Kamal D Mehta

5

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Europe PubMed Central

PMC publication ID

21 August 2017

language of work or name

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publication date

1 September 2007

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Europe PubMed Central

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21 August 2017

Biochemical Pharmacology

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Europe PubMed Central

PMC publication ID

21 August 2017

75

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Europe PubMed Central

PMC publication ID

21 August 2017

2

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

457-467

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Glycogen branches out: new perspectives on the role of glycogen metabolism in the integration of metabolic pathways.

1 reference

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Selective repression of low-density lipoprotein receptor expression by SP600125: coupling of histone H3-Ser10 phosphorylation and Sp1 occupancy

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AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

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Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke

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AMP-activated protein kinase regulates gene expression by direct phosphorylation of nuclear proteins

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Role of mitogen-activated protein kinases and protein kinase C in regulating low-density lipoprotein receptor expression

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A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta

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Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway

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S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3

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Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A

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Regulation of glycogen synthesis by amino acids in cultured human muscle cells.

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MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro

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Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism

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A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle

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Troglitazone prevents and reverses dexamethasone induced insulin resistance on glycogen synthesis in 3T3 adipocytes

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Chronic activation of 5'-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle

1 reference

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Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB.

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23 August 2017

AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle

1 reference

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New insights into the role and mechanism of glycogen synthase activation by insulin

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

1 reference

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Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver

1 reference

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Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta.

1 reference

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5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase

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Increases in intracellular calcium dephosphorylate histone H3 at serine 10 in human hepatoma cells: potential role of protein phosphatase 2A-protein kinase CbetaII complex

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Regulatory role of glycogen synthase kinase 3 for transcriptional activity of ADD1/SREBP1c

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Dual regulation of glycogen synthase kinase-3beta by the alpha1A-adrenergic receptor

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Chronic treatment with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside increases insulin-stimulated glucose uptake and GLUT4 translocation in rat skeletal muscles in a fiber type-specific manner

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Inhibition of glycogen synthase kinase-3 by insulin in cultured human skeletal muscle myoblasts

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Prior serum- and AICAR-induced AMPK activation in primary human myocytes does not lead to subsequent increase in insulin-stimulated glucose uptake

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5-Aminoimidazole-4-carboxamide riboside induces apoptosis in Jurkat cells, but the AMP-activated protein kinase is not involved.

1 reference

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1 reference

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Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.

1 reference

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Long-term AICAR administration and exercise prevents diabetes in ZDF rats

1 reference

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5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside causes acute hepatic insulin resistance in vivo

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AMP-activated protein kinase activation by AICAR increases both muscle fatty acid and glucose uptake in white muscle of insulin-resistant rats in vivo

1 reference

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1 September 2018

Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.

1 reference

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5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes

1 reference

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AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5312663

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1 reference

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AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes

1 reference

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The 5'-AMP-activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/17945190

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based on heuristic

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Identification of a novel cis-acting element participating in maximal induction of the human low density lipoprotein receptor gene transcription in response to low cellular cholesterol levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/17945190

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based on heuristic

inferred from PubMed ID database lookup

Glycogen synthase from rabbit skeletal muscle; effect of insulin on the state of phosphorylation of the seven phosphoserine residues in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17945190

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17945190

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin and exercise decrease glycogen synthase kinase-3 activity by different mechanisms in rat skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/17945190

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of glycogen synthase by hierarchal protein phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17945190

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17945190

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

One-way cross-talk between p38(MAPK) and p42/44(MAPK). Inhibition of p38(MAPK) induces low density lipoprotein receptor expression through activation of the p42/44(MAPK) cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/17945190

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-Aminoimidazole-4-Carboxamide-1- -D-Ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-Activated Protein Kinase-Independent Effect on Glucokinase Translocation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17945190

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/17945190

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of multisite phosphorylation and inactivation of rabbit muscle glycogen synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17945190

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AMP-activated protein kinase counteracted the inhibitory effect of glucose on the phosphoenolpyruvate carboxykinase gene expression in rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17945190

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of glucocorticoid-induced apoptosis with 5-aminoimidazole-4-carboxamide ribonucleoside, a cell-permeable activator of AMP-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17945190

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human muscle glycogen resynthesis after exercise: insulin-dependent and -independent phases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17945190

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BCP.2007.08.028

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

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