Activated astrocytes: a therapeutic target in Alzheimer's disease? (Q37630535)

21 August 2017

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title

Activated astrocytes: a therapeutic target in Alzheimer's disease? (English)

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21 August 2017

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Stacey Fuller

1

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PubMed ID

19903019

21 August 2017

Gerald Münch

series ordinal

2

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PubMed ID

19903019

21 August 2017

Megan Steele

series ordinal

3

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21 August 2017

1 November 2009

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Expert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disorders

21 August 2017

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21 August 2017

9

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21 August 2017

11

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21 August 2017

1585-1594

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Staging of Alzheimer's disease-related neurofibrillary changes

21 August 2017

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Alzheimer's disease and inflammation: a review of cellular and therapeutic mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Activation of microglial cells by beta-amyloid protein and interferon-gamma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Inflammatory mechanisms in Alzheimer disease: the role of beta-amyloid/glial interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Modulation of astrocytic metabolic phenotype by proinflammatory cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Astroglia in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Lactate involvement in neuron-glia metabolic interaction: (13)C-NMR spectroscopy contribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Neuron-astrocyte interactions: partnership for normal function and disease in the central nervous system

21 January 2018

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https://api.crossref.org/works/10.1586%2FERN.09.111

Human brain glycogen content and metabolism: implications on its role in brain energy metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Imaging the metabolic footprint of Glut1 deficiency on the brain

21 January 2018

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https://api.crossref.org/works/10.1586%2FERN.09.111

Interaction between astrocytes and neurons studied using a mathematical model of compartmentalized energy metabolism

21 January 2018

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https://api.crossref.org/works/10.1586%2FERN.09.111

Cellular bases of functional brain imaging: insights from neuron-glia metabolic coupling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging.

21 January 2018

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https://api.crossref.org/works/10.1586%2FERN.09.111

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Astrocytes generate Na+-mediated metabolic waves

21 January 2018

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https://api.crossref.org/works/10.1586%2FERN.09.111

Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Pathways of neuron-astrocyte interactions and their possible role in neuroprotection.

21 January 2018

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https://api.crossref.org/works/10.1586%2FERN.09.111

Aminopeptidase N mediates the utilization of the GSH precursor CysGly by cultured neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Metabolism and functions of glutathione in brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Advanced glycation endproducts change glutathione redox status in SH-SY5Y human neuroblastoma cells by a hydrogen peroxide dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Regulation of astrocyte GFAP expression by TGF-beta1 and FGF-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Reactive astrocytes: cellular and molecular cues to biological function

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Inflammation and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Pro-inflammatory effect of freshly solubilized beta-amyloid peptides in the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Coexistence of paired helical filaments and glial filaments in astrocytic processes within ghost tangles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Alarmins: chemotactic activators of immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Toll-like receptor 3 on adult human astrocytes triggers production of neuroprotective mediators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Cultured astrocytes express toll-like receptors for bacterial products.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

A new in vitro model of the glial scar inhibits axon growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Cultured human fetal astrocytes can be induced by interferon-gamma to express HLA-DR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Immunohistochemical studies of adult human glial cells

21 January 2018

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https://api.crossref.org/works/10.1586%2FERN.09.111

The role of inflammation in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Immune function of astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Lamina-specific arrangement of astrocytic gliosis and senile plaques in Alzheimer's disease visual cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Increased S100 beta neurotrophic activity in Alzheimer's disease temporal lobe

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

RAGE and Alzheimer's disease: a progression factor for amyloid-beta-induced cellular perturbation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Glial cytokines in Alzheimer's disease: review and pathogenic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Inflammation and the degenerative diseases of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Oxidative modification of creatine kinase BB in Alzheimer's disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Protein oxidation in the brain in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Proteomic identification of nitrated proteins in Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Aberrant expression of NOS isoforms in Alzheimer's disease is structurally related to nitrotyrosine formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Expression of nitric oxide system in clinically evaluated cases of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Nitric oxide and peroxynitrite in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Omega-3 fatty acids, energy substrates, and brain function during aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer's Disease Treatment Studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Immature type-1 astrocytes suppress glial scar formation, are motile and interact with blood vessels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Nitrosative stress, cellular stress response, and thiol homeostasis in patients with Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

The cerebrocortical areas in normal brain aging and in Alzheimer's disease: noticeable differences in the lipid peroxidation level and in antioxidant defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

An increase in S-glutathionylated proteins in the Alzheimer's disease inferior parietal lobule, a proteomics approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

S-glutathionylation: from redox regulation of protein functions to human diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Molecular mechanisms and potential clinical significance of S-glutathionylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Reactive oxygen species, cell signaling, and cell injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Inhibitors of protein phosphatase 1 and 2A differentially regulate the expression of inducible nitric-oxide synthase in rat astrocytes and macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Controlled trial of N-acetylcysteine for patients with probable Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Oxidative stress impairs glutamate uptake in fibroblasts from patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

Effects of peroxynitrite-induced protein modifications on tyrosine phosphorylation and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.111

21 January 2018

Identifiers

DOI

10.1586/ERN.09.111

1 reference

21 August 2017

1 reference

PubMed ID

19903019