Cardiovascular disease-related genes and regulation by diet (Q37620446)

21 August 2017

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title

Cardiovascular disease-related genes and regulation by diet (English)

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21 August 2017

cardiovascular disease

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John P Vanden Heuvel

1

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21 August 2017

1 November 2009

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Current Atherosclerosis Reports

21 August 2017

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21 August 2017

11

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21 August 2017

6

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21 August 2017

448-455

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https://scigraph.springernature.com/pub.10.1007/s11883-009-0067-x

21 August 2017

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Conjugated linoleic acid activates peroxisome proliferator-activated receptor alpha and beta subtypes but does not induce hepatic peroxisome proliferation in Sprague-Dawley rats

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The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation

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Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets

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Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor.

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PPAR gamma is required for placental, cardiac, and adipose tissue development

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Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.

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A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia

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Antiatherosclerotic effect of farnesoid X receptor

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LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

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Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain.

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Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha

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PPARdelta is a very low-density lipoprotein sensor in macrophages

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Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha

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Differential activation of adipogenesis by multiple PPAR isoforms.

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Differential activation of peroxisome proliferator-activated receptors by eicosanoids.

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Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay

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FXR as a novel therapeutic target for vascular disease

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Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta)

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Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs

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Synthetic LXR ligand inhibits the development of atherosclerosis in mice

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Modulation of enzymatic activities by n-3 polyunsaturated fatty acids to support cardiovascular health

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The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands

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Optimal diets for prevention of coronary heart disease

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Peroxisome proliferator-activated receptor agonists.

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Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice

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The role of liver X receptor-alpha in the fatty acid regulation of hepatic gene expression

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Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis.

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12 December 2020

Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain

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12 December 2020

Phytanic acid is a retinoid X receptor ligand

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12 December 2020

The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta)

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12 December 2020

Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase

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12 December 2020

PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL

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12 December 2020

10.1007/S11883-009-0067-X

Identifiers

DOI

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21 August 2017

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PubMed ID

19852886