NMR spectroscopy brings invisible protein states into focus (Q37617946)

21 August 2017

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title

NMR spectroscopy brings invisible protein states into focus (English)

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21 August 2017

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2

Lewis E Kay

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21 August 2017

Andrew J Baldwin

1

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21 August 2017

1 November 2009

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21 August 2017

Nature Chemical Biology

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21 August 2017

5

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21 August 2017

808-814

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21 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nchembio.238

21 August 2017

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Open-to-closed transition in apo maltose-binding protein observed by paramagnetic NMR

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Alternate binding modes for a ubiquitin-SH3 domain interaction studied by NMR spectroscopy

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Direct observation of the dynamic process underlying allosteric signal transmission.

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Enzyme dynamics during catalysis

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Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle.

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Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair

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Visualizing transient events in amino-terminal autoprocessing of HIV-1 protease.

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Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR.

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An 15N NMR spin relaxation dispersion study of the folding of a pair of engineered mutants of apocytochrome b562.

21 January 2018

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Millisecond protein folding studied by NMR spectroscopy

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Abp1p and Fyn SH3 domains fold through similar low-populated intermediate states

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Multistate folding of the villin headpiece domain

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Identification of a collapsed intermediate with non-native long-range interactions on the folding pathway of a pair of Fyn SH3 domain mutants by NMR relaxation dispersion spectroscopy

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Phi-value analysis of a three-state protein folding pathway by NMR relaxation dispersion spectroscopy

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Visualizing lowly-populated regions of the free energy landscape of macromolecular complexes by paramagnetic relaxation enhancement

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Sending signals dynamically

21 January 2018

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Complexity and simplicity of ligand-macromolecule interactions: the energy landscape perspective

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli

21 January 2018

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The dynamic energy landscape of dihydrofolate reductase catalysis

21 January 2018

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Conformational relaxation following hydride transfer plays a limiting role in dihydrofolate reductase catalysis

21 January 2018

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Sub-microsecond protein folding

21 January 2018

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Comparison of the backbone dynamics of a folded and an unfolded SH3 domain existing in equilibrium in aqueous buffer.

21 January 2018

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Theoretical and experimental demonstration of the importance of specific nonnative interactions in protein folding

21 January 2018

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The folding kinetics and thermodynamics of the Fyn-SH3 domain.

21 January 2018

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Dramatic acceleration of protein folding by stabilization of a nonnative backbone conformation

21 January 2018

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Protein folding: the stepwise assembly of foldon units

21 January 2018

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From the first protein structures to our current knowledge of protein folding: delights and scepticisms

21 January 2018

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NMR analysis of the conformational properties of the trapped on-pathway folding intermediate of the bacterial immunity protein Im7.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.238

Quantitative NMR spectroscopy of supramolecular complexes: dynamic side pores in ClpP are important for product release

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.238

Slow dynamics in folded and unfolded states of an SH3 domain

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.238

Carbonyl carbon transverse relaxation dispersion measurements and ms-micros timescale motion in a protein hydrogen bond network

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.238

Measurement of bond vector orientations in invisible excited states of proteins

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.238

Measurement of methyl axis orientations in invisible, excited states of proteins by relaxation dispersion NMR spectroscopy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.238

Reconstructing NMR spectra of "invisible" excited protein states using HSQC and HMQC experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.238

Fractional 13C enrichment of isolated carbons using [1-13C]- or [2-13C]-glucose facilitates the accurate measurement of dynamics at backbone Cα and side-chain methyl positions in proteins

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.238

A microscopic view of chemical exchange: Monte Carlo simulation of molecular association

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.238

Nature of Forces between Large Molecules of Biological Interest*

21 January 2018

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Quantitative dynamics and binding studies of the 20S proteasome by NMR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.238

Probing Chemical Shifts of Invisible States of Proteins with Relaxation Dispersion NMR Spectroscopy: How Well Can We Do?

21 January 2018

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Evidence for flexibility in the function of ribonuclease A

21 January 2018

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12 December 2020

Quantifying two-bond 1HN-13CO and one-bond 1H(alpha)-13C(alpha) dipolar couplings of invisible protein states by spin-state selective relaxation dispersion NMR spectroscopy

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12 December 2020

Investigation of protein motions via relaxation measurements

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12 December 2020

The folding pathway of an FF domain: characterization of an on-pathway intermediate state under folding conditions by (15)N, (13)C(alpha) and (13)C-methyl relaxation dispersion and (1)H/(2)H-exchange NMR spectroscopy

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12 December 2020

Proton magnetic resonance studies of the tyrosine residues of hen lysozyme-assignment and detection of conformational mobility

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12 December 2020

An x-ray study of azide methaemoglobin

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Probing structure in invisible protein states with anisotropic NMR chemical shifts

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Dynamics of ligand binding to myoglobin

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12 December 2020

Flap opening and dimer-interface flexibility in the free and inhibitor-bound HIV protease, and their implications for function

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12 December 2020

Exchange of hydrogen atoms in insulin with deuterium atoms in aqueous solutions

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12 December 2020

Using relaxation dispersion NMR spectroscopy to determine structures of excited, invisible protein states

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12 December 2020

Isotope labeling methods for studies of excited protein states by relaxation dispersion NMR spectroscopy

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12 December 2020

MECHANISM OF ENZYME CATALYSIS

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12 December 2020

Internal motion of proteins: nuclear magnetic resonance measurements and dynamic simulations

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12 December 2020

Extending the range of amide proton relaxation dispersion experiments in proteins using a constant-time relaxation-compensated CPMG approach

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12 December 2020

Remarkably slow folding of a small protein

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12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.238

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21 August 2017

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PubMed ID

19841630