HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response. (Q37612752)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24516159%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

title

HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response (English)

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7 March 2020

2

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Dagmar E Ehrnhoefer

3

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Niels Skotte

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Syam Prakash Somasekharan

7 March 2020

8

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Mads Daugaard

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Roberto Nitsch

19

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Christopher A Ahern

21

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Josef Penninger

23

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Michael R. Hayden

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1

Barak Rotblat

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7 March 2020

author name string

Martina Metzler

5

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Sonia Franciosi

6

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Gabriel Leprivier

7

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Adi Barokas

9

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Yu Deng

10

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7 March 2020

Tiffany Tang

11

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7 March 2020

Joan Mathers

12

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Naniye Cetinbas

13

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Brian Kwok

15

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7 March 2020

Liheng Li

16

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7 March 2020

Christopher J Carnie

17

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Dieter Fink

18

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7 March 2020

Jason D Galpin

20

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7 March 2020

Gerry Melino

22

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7 March 2020

Poul H Sorensen

25

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language of work or name

English

0 references

publication date

10 February 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24516159%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

7 March 2020

published in

1 reference

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volume

111

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issue

8

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7 March 2020

page(s)

3032-3037

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describes a project that uses

7 March 2020

ImageJ

1 reference

11 June 2022

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based on heuristic

inferred from PubMed Central ID database lookup

cites work

Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin

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Role of cerebral cortex in the neuropathology of Huntington's disease

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The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1

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Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

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In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons

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Molecular mechanisms and potential therapeutical targets in Huntington's disease

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Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

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23 August 2017

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25 June 2018

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1 September 2018

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Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

1 September 2018

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1 September 2018

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The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers

1 September 2018

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2 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24516159

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1314421111

1 reference

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7 March 2020

0 references

1 reference

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7 March 2020

1 reference

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