Regulation of human hepatic drug transporter expression by pro-inflammatory cytokines (Q37604385)

21 August 2017

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title

Regulation of human hepatic drug transporter expression by pro-inflammatory cytokines (English)

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21 August 2017

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Olivier Fardel

1

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PubMed ID

19785515

21 August 2017

Marc Le Vée

series ordinal

2

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PubMed ID

19785515

21 August 2017

language of work or name

English

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publication date

1 December 2009

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Expert Opinion on Drug Metabolism & Toxicology

21 August 2017

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21 August 2017

5

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21 August 2017

12

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21 August 2017

1469-1481

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Altered theophylline pharmacokinetics during acute respiratory viral illness

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Inflammatory response: an unrecognised source of variability in the pharmacokinetics and pharmacodynamics of cancer chemotherapy

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Regulation of cytochromes P450 during inflammation and infection.

21 January 2018

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Endotoxin depresses hepatic cytochrome P450-mediated drug metabolism in women

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Regulation of drug-metabolizing enzymes and transporters in inflammation

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Cytokines in acute and chronic inflammation

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Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes.

21 January 2018

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Decreased expression of cytochromes P450 1A2, 2E1, and 3A4 and drug transporters Na+-taurocholate-cotransporting polypeptide, organic cation transporter 1, and organic anion-transporting peptide-C correlates with the progression of liver fibrosis in

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Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance

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Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes.

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Transporters as a determinant of drug clearance and tissue distribution

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Drug transport proteins in the liver

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Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration

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Hepatocyte transport of bile acids and organic anions in endotoxemic rats: impaired uptake and secretion

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Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats

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Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis

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Cytokine-dependent regulation of hepatic organic anion transporter gene transactivators in mouse liver

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Regulation of drug transporters during infection and inflammation.

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Regulation of transporters by nuclear hormone receptors: implications during inflammation.

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Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta

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Regulation of drug transporter expression in human hepatocytes exposed to the proinflammatory cytokines tumor necrosis factor-alpha or interleukin-6.

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Identification of interspecies difference in efflux transporters of hepatocytes from dog, rat, monkey and human.

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Clinical versatility of porcine hepatocytes in the light of interspecies differences in cytochrome P450 regulation and expression

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Expression and regulation of hepatic drug and bile acid transporters

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Drug uptake systems in liver and kidney

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Bile acid transporters: structure, function, regulation and pathophysiological implications

21 January 2018

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Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.

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Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family

21 January 2018

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Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination

21 January 2018

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The organic anion transporter (OATP) family.

21 January 2018

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Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties

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Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

21 January 2018

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Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles

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Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3).

21 January 2018

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Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications

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The complexities of hepatic drug transport: current knowledge and emerging concepts.

21 January 2018

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Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception

21 January 2018

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A human transporter protein that mediates the final excretion step for toxic organic cations

21 January 2018

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The P-glycoprotein multidrug transporter

21 January 2018

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The ATP-binding cassette transporters and their implication in drug disposition: a special look at the heart

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The bile salt export pump

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Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin

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Physiological, pharmacological and clinical features of the multidrug resistance protein 2.

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The apical conjugate efflux pump ABCC2 (MRP2).

21 January 2018

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ABCG2: a perspective.

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Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2.

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Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes.

21 January 2018

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Differential regulation of multidrug resistance-associated protein 2 (MRP2) and cytochromes P450 2B1/2 and 3A1/2 in phenobarbital-treated hepatocytes.

21 January 2018

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Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump

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LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process.

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Evidence for anti-inflammatory activity of statins and PPARalpha activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro

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Cytokines Alter the Expression and Activity of the Multidrug Resistance Transporters in Human Hepatoma Cell Lines; Analysis Using RT‐PCR and cDNA Microarrays

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Production of serum amyloid A and C-reactive protein by HepG2 cells stimulated with combinations of cytokines or monocyte conditioned media: the effects of prednisolone

21 January 2018

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Induction of ABCC3 (MRP3) by pregnane X receptor activators

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Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line

21 January 2018

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The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics

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Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells

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21 January 2018

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Functional expression of sinusoidal drug transporters in primary human and rat hepatocytes

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P-glycoprotein expression in human, mouse, hamster and rat hepatocytes in primary culture.

21 January 2018

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Decreased expression of an ATP-binding cassette transporter, MRP2, in human livers with hepatitis C virus infection

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Interleukin-1beta represses MRP2 gene expression through inactivation of interferon regulatory factor 3 in HepG2 cells

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A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene

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Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.

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Human hepatocytes: isolation, cryopreservation and applications in drug development

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In vitro-in vivo correlation of hepatobiliary drug clearance in humans.

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Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia.

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Interleukin-1 beta-mediated suppression of RXR:RAR transactivation of the Ntcp promoter is JNK-dependent

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Inflammation and interleukin-6 mediate reductions in the hepatic expression and transcription of the mdr1a and mdr1b Genes.

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Decreased expression of P-glycoprotein in interleukin-1beta and interleukin-6 treated rat hepatocytes.

21 January 2018

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Effect of tumor necrosis factor-alpha and interferon-gamma on intestinal P-glycoprotein expression, activity, and localization in Caco-2 cells

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The impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC.

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Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver.

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The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice

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The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha

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Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors

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Taurine supplementation induces multidrug resistance protein 2 and bile salt export pump expression in rats and prevents endotoxin-induced cholestasis

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An update on metabolism studies using human hepatocytes in primary culture

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Acute-phase response of human hepatocytes: Regulation of acute-phase protein synthesis by interleukin-6

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10.1517/17425250903304056

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference

PubMed ID

19785515