The LRRK2 G2019S mutation as the cause of Parkinson's disease in Ashkenazi Jews (Q37597933)

21 August 2017

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title

The LRRK2 G2019S mutation as the cause of Parkinson's disease in Ashkenazi Jews (English)

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21 August 2017

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3

Ziv Gan-Or

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21 August 2017

5

Nir Giladi

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21 August 2017

4

Avi Orr-Urtreger

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21 August 2017

2

Elissa Ash

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21 August 2017

1

Avner Thaler

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PubMed ID

19756366

21 August 2017

language of work or name

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1 November 2009

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Journal of Neural Transmission

21 August 2017

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21 August 2017

116

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21 August 2017

11

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21 August 2017

1473-1482

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https://scigraph.springernature.com/pub.10.1007/s00702-009-0303-0

21 August 2017

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The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

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LRRK2 G2019S is a common mutation in Spanish patients with late-onset Parkinson's disease

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Contrasting patterns of Y chromosome variation in Ashkenazi Jewish and host non-Jewish European populations

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Genetic analysis for five LRRK2 mutations in a Sardinian parkinsonian population: importance of G2019S and R1441C mutations in sporadic Parkinson's disease patients.

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LRRK2 and neurodegeneration

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The G2019S LRRK2 mutation is rare in Korean patients with Parkinson's disease.

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Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration

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Identification and haplotype analysis of LRRK2 G2019S in Japanese patients with Parkinson disease

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A clinic-based screening of mutations in exons 31, 34, 35, 41, and 48 of LRRK2 in Iranian Parkinson's disease patients.

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LRRK2 G2019S mutation and Parkinson's disease: a clinical, neuropsychological and neuropsychiatric study in a large Italian sample

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Validity and Utility of a LRRK2 G2019S Mutation Test for the Diagnosis of Parkinson's Disease

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12 December 2020

The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor

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Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies

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Ashkenazi Parkinson's disease patients with the LRRK2 G2019S mutation share a common founder dating from the second to fifth centuries

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12 December 2020

Clinical characteristics of Parkinson's disease among Jewish Ethnic groups in Israel

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The familial Parkinsonism gene LRRK2 regulates neurite process morphology

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LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews.

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The prevalence of the G2019S and R1441C/G/H mutations in LRRK2 in German patients with Parkinson's disease

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LRRK2 mutations are a common cause of Parkinson's disease in Spain

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Increased frequency of the LRRK2 G2019S mutation in an elderly Ashkenazi Jewish population is not associated with dementia

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Leucine-rich repeat kinase 2 (LRRK2) mutations in a Swedish Parkinson cohort and a healthy nonagenarian

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LRRK2 G2019S in families with Parkinson disease who originated from Europe and the Middle East: evidence of two distinct founding events beginning two millennia ago.

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Lrrk2 pathogenic substitutions in Parkinson's disease

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Update on the functional biology of Lrrk2.

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LRRK2 haplotype analyses in European and North African families with Parkinson disease: a common founder for the G2019S mutation dating from the 13th century

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PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation

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Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations

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Clinical features of LRRK2-associated Parkinson's disease in central Norway

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12 December 2020

Genetic and clinical identification of Parkinson's disease patients with LRRK2 G2019S mutation

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Hyposmia in G2019S LRRK2-related parkinsonism: clinical and pathologic data.

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Frequency and phenotypes of LRRK2 G2019S mutation in Italian patients with Parkinson's disease

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LRRK2 mutation in familial Parkinson’s disease in a Taiwanese population: clinical, PET, and functional studies

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Evaluation of LRRK2 G2019S penetrance: Relevance for genetic counseling in Parkinson disease

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12 December 2020

LRRK2 mutations in Parkinson disease

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Parkinson disease in twins: an etiologic study

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12 December 2020

Genetic screening for LRRK2 gene G2019S mutation in Parkinson's disease patients from Southern Italy

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12 December 2020

Progression of dopaminergic dysfunction in a LRRK2 kindred: a multitracer PET study

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12 December 2020

LRRK2 mutations in patients with Parkinson's disease from Peru and Uruguay

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12 December 2020

LRRK2G2019S as a Cause of Parkinson's Disease in North African Arabs

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12 December 2020

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

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12 December 2020

LRRK2 low-penetrance mutations (Gly2019Ser) and risk alleles (Gly2385Arg)-linking familial and sporadic Parkinson's disease

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12 December 2020

Genetic screening of the G2019S mutation of the LRRK2 gene in Southwest European, North African, and Sephardic Jewish subjects

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12 December 2020

The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study

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12 December 2020

A common leucine-rich repeat kinase 2 gene mutation in familial and sporadic Parkinson's disease in Russia

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12 December 2020

Prevalence and clinical features of common LRRK2 mutations in Australians with Parkinson's disease.

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12 December 2020

LRRK2 and GBA mutations differentially affect the initial presentation of Parkinson disease.

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12 December 2020

Striatal dopamine transporter binding in Parkinson's disease associated with the LRRK2 Gly2019Ser mutation.

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12 December 2020

Analysis of LRRK2 G2019S and I2020T mutations in Parkinson's disease

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12 December 2020

The leucine rich repeat kinase 2 (LRRK2) G2019S substitution mutation. Association with Parkinson disease, malignant melanoma and prevalence in ethnic groups in Israel.

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12 December 2020

LRRK2 is not a significant cause of Parkinson's disease in French-Canadians

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12 December 2020

Frequency of the LRRK2 G2019S mutation in Italian patients affected by Parkinson's disease.

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12 December 2020

Clinicogenetic study of mutations inLRRK2 exon 41 in Parkinson's disease patients from 18 countries

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12 December 2020

Genetics of Parkinson's disease and parkinsonism

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12 December 2020

The G2019S LRRK2 mutation is uncommon amongst Greek patients with sporadic Parkinson's disease

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12 December 2020

G2019S LRRK2 mutation in French and North African families with Parkinson's disease

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12 December 2020

Parkinsonism, Lrrk2 G2019S, and tau neuropathology

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12 December 2020

LRRK2 mutations in Spanish patients with Parkinson disease: frequency, clinical features, and incomplete penetrance

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12 December 2020

Clinical Heterogeneity of the LRRK2 G2019S Mutation

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12 December 2020

A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations

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12 December 2020

Parkinson disease, 10 years after its genetic revolution: multiple clues to a complex disorder

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12 December 2020

LRRK2 G2019S and R1441G mutations associated with Parkinson's disease are common in the Basque Country, but relative prevalence is determined by ethnicity.

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12 December 2020

High prevalence of LRRK2 mutations in familial and sporadic Parkinson's disease in Portugal

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12 December 2020

Screening for LRRK2 mutations in patients with Parkinson's disease in Russia: identification of a novel LRRK2 variant

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12 December 2020

Contribution of somal Lewy bodies to neuronal death.

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12 December 2020

Genetic screening for two LRRK2 mutations in French patients with idiopathic Parkinson's disease

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12 December 2020

LRRK2 expression in normal and pathologic human brain and in human cell lines

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12 December 2020

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

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12 December 2020

Frequency of LRRK2 mutations in early- and late-onset Parkinson disease.

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12 December 2020

The G2019S LRRK2 mutation is uncommon in an Asian cohort of Parkinson's disease patients.

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12 December 2020

G2019S LRRK2 mutation in familial and sporadic Parkinson's disease in Russia

1 reference

12 December 2020

The LRRK2 G2019S mutation in Ashkenazi Jews with Parkinson disease: is there a gender effect?

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12 December 2020

Is the G2019S LRRK2 mutation common in all southern European populations?

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12 December 2020

Clinical features of Parkinson disease patients with homozygous leucine-rich repeat kinase 2 G2019S mutations.

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12 December 2020

G2019S dardarin substitution is a common cause of Parkinson's disease in a Portuguese cohort

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12 December 2020

LRRK2 Gly2019Ser penetrance in Arab-Berber patients from Tunisia: a case-control genetic study

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12 December 2020

Genotype-phenotype correlations between GBA mutations and Parkinson disease risk and onset

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12 December 2020

Molecular biology changes associated with LRRK2 mutations in Parkinson's disease

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12 December 2020

Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data

1 reference

12 December 2020

Roc, a Ras/GTPase domain in complex proteins

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12 December 2020

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

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12 December 2020

Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease

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12 December 2020

10.1007/S00702-009-0303-0

Identifiers

DOI

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21 August 2017

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PubMed ID

19756366