Organ patterning in the adult stage: the role of Wnt/beta-catenin signaling in liver zonation and beyond (Q37586372)

21 August 2017

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title

Organ patterning in the adult stage: the role of Wnt/beta-catenin signaling in liver zonation and beyond (English)

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21 August 2017

Rolf Gebhardt

1

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PubMed ID

19705440

21 August 2017

Amalya Hovhannisyan

series ordinal

2

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21 August 2017

1 January 2010

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21 August 2017

Developmental Dynamics

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21 August 2017

239

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21 August 2017

1

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21 August 2017

45-55

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Controversy: PPARgamma as a target for treatment of colorectal cancer

21 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

Hepatic nuclear factor 3- and hormone-regulated expression of the phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein 1 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

Zonation of hepatic cytochrome P-450 expression and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Activation of Wnt/beta-catenin pathway during hepatocyte growth factor-induced hepatomegaly in mice

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Diversity of LEF/TCF action in development and disease

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Correlation between beta-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Transgenic Wnt/TCF pathway reporters: all you need is Lef?

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

FoxO proteins in insulin action and metabolism

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Apc tumor suppressor gene is the "zonation-keeper" of mouse liver

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Zonal gene expression in mouse liver resembles expression patterns of Ha-ras and beta-catenin mutated hepatomas

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Serum components and activated Ha-ras antagonize expression of perivenous marker genes stimulated by beta-catenin signaling in mouse hepatocytes

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

The Wnt/beta-catenin pathway: master regulator of liver zonation?

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Liver specification: a new role for Wnts in liver development.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Wnt/beta-catenin pathway in hepatocellular carcinoma pathogenesis and liver physiology.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Convergence of Wnt signaling on the HNF4alpha-driven transcription in controlling liver zonation.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Stabilization of beta-catenin affects mouse embryonic liver growth and hepatoblast fate.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Cross-regulation of beta-catenin-LEF/TCF and retinoid signaling pathways

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Liver microvascular architecture: an insight into the pathophysiology of portal hypertension

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Functional interaction between beta-catenin and FOXO in oxidative stress signaling

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Metabolic zonation of the liver: regulation and implications for liver function

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Cell-cell interactions: clues to hepatocyte heterogeneity and beyond?

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Cell-cell interactions in the regulation of the expression of hepatic enzymes.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Heterogeneous distribution of glutamine synthetase among rat liver parenchymal cells in situ and in primary culture.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Glutamine synthetase and hepatocarcinogenesis.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Zonal gene expression in murine liver: Are tumors helping us to solve the mystery?

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Differential effect of growth factors on growth stimulation and phenotypic stability of glutamine-synthetase-positive and -negative hepatocytes in primary culture

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Glutamine synthetase heterogeneous expression as a marker for the cellular lineage of preneoplastic and neoplastic liver populations.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Heterogeneous (positional) expression of hepatic glutamine synthetase: features, regulation and implications for hepatocarcinogenesis

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Hepatocellular expression of glutamine synthetase: an indicator of morphogen actions as master regulators of zonation in adult liver

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

A theory of biological pattern formation.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

FOXO transcription factors at the interface between longevity and tumor suppression

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

The role of FoxO in the regulation of metabolism.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Zonal gene expression in murine liver: lessons from tumors

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Regulation of Wnt/beta-catenin pathway by cPLA2alpha and PPARdelta

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Interaction of FOXO with beta-catenin inhibits beta-catenin/T cell factor activity

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Wnt/beta-catenin signaling in murine hepatic transit amplifying progenitor cells.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Wnt impacts growth and differentiation in ex vivo liver development.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

The Wnt/beta-catenin signaling pathway targets PPARgamma activity in colon cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

The WNT signalling pathway and diabetes mellitus

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Wnt and beyond Wnt: multiple mechanisms control the transcriptional property of beta-catenin

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Oxygen: modulator of metabolic zonation and disease of the liver

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

From individual Wnt pathways towards a Wnt signalling network.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Oxygen: modulator of physiological and pathophysiological processes in the liver

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Hepatic enzymic zonation: a reevaluation of the concept of the liver acinus

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Deficiency of manganese superoxide dismutase in hepatocytes disrupts zonated gene expression in mouse liver

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Synergistic effects of coactivators GRIP1 and beta-catenin on gene activation: cross-talk between androgen receptor and Wnt signaling pathways

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Hypoxia-inducible factor-1alpha obstructs a Wnt signaling pathway by inhibiting the hARD1-mediated activation of beta-catenin

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Regulating the balance between peroxisome proliferator-activated receptor gamma and beta-catenin signaling during adipogenesis. A glycogen synthase kinase 3beta phosphorylation-defective mutant of beta-catenin inhibits expression of a subset of adip

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Functional interaction between peroxisome proliferator-activated receptor gamma and beta-catenin

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

A beta-catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Wnt9a secreted from the walls of hepatic sinusoids is essential for morphogenesis, proliferation, and glycogen accumulation of chick hepatic epithelium

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Dehydroepiandrosterone increases the zone [correction of in zone] of glutamine synthetase-positive hepatocytes in female rat liver: a putative androgenic effect

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

https://api.crossref.org/works/10.1002%2FDVDY.22041

1 reference

7 January 2021

Changes in WNT/beta-catenin pathway during regulated growth in rat liver regeneration

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

GFP transgenic mice reveal active canonical Wnt signal in neonatal brain and in adult liver and spleen.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know?

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Wnt/beta-catenin signaling in hepatic organogenesis

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Mammalian Wnt3a is released on lipoprotein particles

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Liganded androgen receptor interaction with beta-catenin: nuclear co-localization and modulation of transcriptional activity in neuronal cells

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Elevated levels of hepatocyte nuclear factor 3beta in mouse hepatocytes influence expression of genes involved in bile acid and glucose homeostasis

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Hedgehog in Wnterland

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Stereological measurement of porto-central gradients in gene expression in mouse liver

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

https://api.crossref.org/works/10.1002%2FDVDY.22041

1 reference

7 January 2021

Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Zebrafish and the understanding of liver development: the emerging role of the Wnt pathway in liver biology

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Trans-repression of beta-catenin activity by nuclear receptors

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

The molecular basis of vitamin D receptor and beta-catenin crossregulation.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

WNT and DKK determine hair follicle spacing through a reaction-diffusion mechanism.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Strain- and sex-specific variations in hepatic glutamine synthetase activity and distribution in rats and mice.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Transcriptional control in the mammalian liver: liver development, perinatal repression, and zonal gene regulation.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Wnt signaling in liver cancer

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Conditional deletion of beta-catenin reveals its role in liver growth and regeneration

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

The chemical basis of morphogenesis

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Dose response effects of 2-acetylaminofluorene on DNA damage, cytotoxicity, cell proliferation and neoplastic conversion in rat liver

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

FOXO-binding partners: it takes two to tango

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Transcriptional regulation of peroxisome proliferator-activated receptors and liver X receptors.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Unexpected Hedgehog-Wnt interactions in epithelial differentiation

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Growth hormone regulation of sex-dependent liver gene expression

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Hepatic expression of glutamine synthetase in rats is controlled by STAT5 and TCF transcription factors

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Non-linearity of neoplastic conversion induced in rat liver by low exposures to diethylnitrosamine

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

The PPARs: from orphan receptors to drug discovery

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Linking beta-catenin to androgen-signaling pathway

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Wnt'er in liver: expression of Wnt and frizzled genes in mouse.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22041

7 January 2021

Identifiers

DOI

10.1002/DVDY.22041

1 reference

21 August 2017

1 reference

PubMed ID

19705440