Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth (Q37568665)

21 August 2017

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth (English)

1 reference

21 August 2017

reactive oxygen species

1 reference

0 references

12

Michael J Keating

1 reference

21 August 2017

Shira L Cramer

1

1 reference

21 August 2017

Achinto Saha

2

1 reference

21 August 2017

Jinyun Liu

3

1 reference

21 August 2017

Surendar Tadi

4

1 reference

21 August 2017

Stefano Tiziani

5

1 reference

21 August 2017

Wupeng Yan

6

1 reference

21 August 2017

Kendra Triplett

7

1 reference

21 August 2017

Candice Lamb

8

1 reference

21 August 2017

Susan E Alters

9

1 reference

21 August 2017

Scott Rowlinson

10

1 reference

21 August 2017

Yan Jessie Zhang

11

1 reference

21 August 2017

Peng Huang

13

1 reference

21 August 2017

John DiGiovanni

14

1 reference

21 August 2017

George Georgiou

15

1 reference

21 August 2017

Everett Stone

16

1 reference

21 August 2017

language of work or name

English

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publication date

21 November 2016

1 reference

21 August 2017

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21 August 2017

23

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21 August 2017

120-127

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21 August 2017

1

1 reference

describes a project that uses

21 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5218918/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/nm.4232

0 references

cites work

Effective elimination of chronic lymphocytic leukemia cells in the stromal microenvironment by a novel drug combination strategy using redox-mediated mechanisms

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Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stress

23 August 2017

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ROS signaling by NADPH oxidase 5 modulates the proliferation and survival of prostate carcinoma cells.

23 August 2017

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23 August 2017

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Transsulfuration Is a Significant Source of Sulfur for Glutathione Production in Human Mammary Epithelial Cells

23 August 2017

1 reference

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The role of iron and reactive oxygen species in cell death

23 August 2017

1 reference

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Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target

23 August 2017

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Loss of p53 and altered miR15-a/16-1MCL-1 pathway in CLL: insights from TCL1-Tg:p53(-/-) mouse model and primary human leukemia cells

23 August 2017

1 reference

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Frequent epigenetic silencing of the folate-metabolising gene cystathionine-beta-synthase in gastrointestinal cancer

23 August 2017

1 reference

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De novo engineering of a human cystathionine-γ-lyase for systemic (L)-Methionine depletion cancer therapy

23 August 2017

1 reference

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The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities.

23 August 2017

1 reference

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Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia

23 August 2017

1 reference

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Regulation of prostate cancer cell invasion by modulation of extra- and intracellular redox balance

23 August 2017

1 reference

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Expression of cystathionine β-synthase and cystathionine γ-lyase in human pregnant myometrium and their roles in the control of uterine contractility

23 August 2017

1 reference

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Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia.

23 August 2017

1 reference

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Features and development of Coot

23 August 2017

1 reference

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23 August 2017

1 reference

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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

23 August 2017

1 reference

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Phasercrystallographic software

23 August 2017

1 reference

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Molecular formula and METLIN Personal Metabolite Database matching applied to the identification of compounds generated by LC/TOF-MS

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218918

Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism

23 August 2017

1 reference

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KEGG Atlas mapping for global analysis of metabolic pathways

23 August 2017

1 reference

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The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

23 August 2017

1 reference

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HMDB: the Human Metabolome Database

23 August 2017

1 reference

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Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity

23 August 2017

1 reference

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

23 August 2017

1 reference

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The origin of allometric scaling laws in biology from genomes to ecosystems: towards a quantitative unifying theory of biological structure and organization

23 August 2017

1 reference

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Linneg Sca-1high CD49fhigh prostate cancer cells derived from the Hi-Myc mouse model are tumor-initiating cells with basal-epithelial characteristics and differentiation potential in vitro and in vivo

23 August 2017

1 reference

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The Yin and Yang of redox regulation.

6 September 2017

1 reference

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xCT, component of cysteine/glutamate transporter, as an independent prognostic factor in human esophageal squamous cell carcinoma

6 September 2017

1 reference

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Redox implications of AMPK-mediated signal transduction beyond energetic clues

6 September 2017

1 reference

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Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels

6 September 2017

1 reference

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The distribution of cystathionine beta-synthase (CBS) in the eye: implication of the presence of a trans-sulfuration pathway for oxidative stress defense

6 September 2017

1 reference

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Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype

6 September 2017

1 reference

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Sulfasalazine-induced cystine starvation: potential use for prostate cancer therapy

14 September 2017

1 reference

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Expression profiling of homocysteine junction enzymes in the NCI60 panel of human cancer cell lines.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218918

Suppression of cystine uptake by sulfasalazine inhibits proliferation of human mammary carcinoma cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218918

Withdrawal of essential amino acids increases autophagy by a pathway involving Ca2+/calmodulin-dependent kinase kinase-β (CaMKK-β)

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218918

Guidelines for clinical protocols for chronic lymphocytic leukemia: recommendations of the National Cancer Institute-sponsored working group

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218918

Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218918

System x(c)- and thioredoxin reductase 1 cooperatively rescue glutathione deficiency

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218918

A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin) in cancer patients

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218918

Increased xCT expression correlates with tumor invasion and outcome in patients with glioblastomas.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218918

Reactive oxygen species signaling in cancer: comparison with aging

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218918

Curcumin stimulates reactive oxygen species production and potentiates apoptosis induction by the antitumor drugs arsenic trioxide and lonidamine in human myeloid leukemia cell lines.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218918

Site-directed mutagenesis on human cystathionine-gamma-lyase reveals insights into the modulation of H2S production

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218918

A functional transsulfuration pathway in the brain links to glutathione homeostasis.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218918

Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218918

Myc-driven murine prostate cancer shares molecular features with human prostate tumors

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218918

Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5218918

Processing of X-ray diffraction data collected in oscillation mode

1 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.4232

Optimized metabolite extraction from blood serum for 1H nuclear magnetic resonance spectroscopy

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.4232

Cystine/glutamate antiporter expression in retinal Müller glial cells: implications for DL-alpha-aminoadipate toxicity

21 January 2018

1 reference

12 December 2020

Expression of cystathionine beta-synthase is downregulated in hepatocellular carcinoma and associated with poor prognosis

1 reference

12 December 2020

[Effect of phenethyl isothiocyanate given at different duration of gestation on the outcome of pregnancy in rats]

1 reference

12 December 2020

Inhibition of RNA transcription: a biochemical mechanism of action against chronic lymphocytic leukemia cells by fludarabine

1 reference

12 December 2020

A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer

1 reference

12 December 2020

Identifiers

DOI

10.1038/NM.4232

1 reference

21 August 2017

1 reference

21 August 2017

1 reference