TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading. (Q37543793)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24474754%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading (English)

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6 March 2020

1 reference

3

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6 March 2020

Farshid Guilak

5

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6 March 2020

author name string

Christopher J O'Conor

1

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6 March 2020

Holly A Leddy

2

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6 March 2020

Wolfgang B Liedtke

4

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6 March 2020

language of work or name

English

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publication date

13 January 2014

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Proceedings of the National Academy of Sciences of the United States of America

6 March 2020

published in

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6 March 2020

volume

111

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6 March 2020

page(s)

1316-1321

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6 March 2020

issue

4

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Chondrocyte channel transcriptomics: do microarray data fit with expression and functional data?

6 March 2020

cites work

1 reference

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Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice.

23 August 2017

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Evaluation of the complex transcriptional topography of mesenchymal stem cell chondrogenesis for cartilage tissue engineering.

23 August 2017

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Dynamic loading enhances integrative meniscal repair in the presence of interleukin-1.

23 August 2017

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Dependence of zonal chondrocyte water transport properties on osmotic environment

23 August 2017

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The vanilloid transient receptor potential channel TRPV4: from structure to disease

23 August 2017

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Signalling cascades in mechanotransduction: cell-matrix interactions and mechanical loading.

23 August 2017

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TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling

23 August 2017

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Calcium signaling in vertebrate embryonic patterning and morphogenesis

23 August 2017

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The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage.

23 August 2017

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Mechanobiology and diseases of mechanotransduction

23 August 2017

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TRPV4 calcium entry channel: a paradigm for gating diversity.

23 August 2017

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Microfilament-associated Protein 7 Increases the Membrane Expression of Transient Receptor Potential Vanilloid 4 (TRPV4)

23 August 2017

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Hypo-osmotic stress induces calcium-dependent actin reorganization in articular chondrocytes.

23 August 2017

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The role of calcium-binding proteins in the control of transcription: structure to function

23 August 2017

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Integrins and stretch activated ion channels; putative components of functional cell surface mechanoreceptors in articular chondrocytes

23 August 2017

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Hyper-osmotic stress induces volume change and calcium transients in chondrocytes by transmembrane, phospholipid, and G-protein pathways.

23 August 2017

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The extracellular matrix, interstitial fluid and ions as a mechanical signal transducer in articular cartilage

23 August 2017

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Biosynthetic response of cartilage explants to dynamic compression

23 August 2017

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Targeting mechanotransduction pathways in osteoarthritis: a focus on the pericellular matrix

23 August 2017

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Mutations in TRPV4 cause an inherited arthropathy of hands and feet.

6 September 2017

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Calmodulin transduces Ca2+ oscillations into differential regulation of its target proteins

6 September 2017

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Depletion of primary cilia in articular chondrocytes results in reduced Gli3 repressor to activator ratio, increased Hedgehog signaling, and symptoms of early osteoarthritis.

14 September 2017

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Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes

14 September 2017

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Functional gene screening system identified TRPV4 as a regulator of chondrogenic differentiation

14 September 2017

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Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins

14 September 2017

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The beneficial effect of delayed compressive loading on tissue-engineered cartilage constructs cultured with TGF-beta3.

25 June 2018

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Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles

25 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910592

Changes in proteoglycan synthesis of chondrocytes in articular cartilage are associated with the time-dependent changes in their mechanical environment.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910592

A triphasic theory for the swelling and deformation behaviors of articular cartilage

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910592

The role of shear-induced transforming growth factor-β signaling in the endothelium

25 June 2018

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Effect of preculture and loading on expression of matrix molecules, matrix metalloproteinases, and cytokines by expanded osteoarthritic chondrocytes

1 September 2018

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TGF-β and osteoarthritis--the good and the bad.

1 September 2018

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Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo.

1 September 2018

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Calcium regulates cyclic compression-induced early changes in chondrocytes during in vitro cartilage tissue formation

1 September 2018

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A mechano-chemical model for the passive swelling response of an isolated chondron under osmotic loading

1 September 2018

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Temporal expression patterns and corresponding protein inductions of early responsive genes in rabbit bone marrow-derived mesenchymal stem cells under cyclic compressive loading.

1 September 2018

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Cyclic mechanical strain regulates the PTHrP expression in cultured chondrocytes via activation of the Ca2+ channel

1 September 2018

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Mechanisms involved in the increase in intracellular calcium following hypotonic shock in bovine articular chondrocytes

1 September 2018

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Mechanical compression influences intracellular Ca2+ signaling in chondrocytes seeded in agarose constructs

1 September 2018

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The effects of matrix compression on proteoglycan metabolism in articular cartilage explants

1 September 2018

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12 December 2020

Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels

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12 December 2020

The influence of mechanical loading on isolated chondrocytes seeded in agarose constructs

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12 December 2020

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The influence of elaborated pericellular matrix on the deformation of isolated articular chondrocytes cultured in agarose

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12 December 2020

Mechanical compression modulates matrix biosynthesis in chondrocyte/agarose culture

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1319569111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24474754%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24474754%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24474754%20AND%20SRC:MED&resulttype=core&format=json