Role of hypoxia-inducible factor-1alpha in angiogenic-osteogenic coupling (Q37470198)

20 August 2017

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title

Role of hypoxia-inducible factor-1alpha in angiogenic-osteogenic coupling (English)

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20 August 2017

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Ryan C Riddle

1

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20 August 2017

Richa Khatri

series ordinal

2

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20 August 2017

Ernestina Schipani

series ordinal

3

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20 August 2017

Thomas L Clemens

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4

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20 August 2017

5 May 2009

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Journal of Molecular Medicine

20 August 2017

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20 August 2017

87

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20 August 2017

583-590

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20 August 2017

6

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https://scigraph.springernature.com/pub.10.1007/s00109-009-0477-9

20 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

23 August 2017

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23 August 2017

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Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival

23 August 2017

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23 August 2017

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23 August 2017

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Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

23 August 2017

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Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand

23 August 2017

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Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1

23 August 2017

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Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

23 August 2017

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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

23 August 2017

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23 August 2017

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Vasculotropin/vascular endothelial growth factor induces differentiation in cultured osteoblasts

23 August 2017

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23 August 2017

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Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4.

23 August 2017

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The influence of diabetes mellitus on the healing of closed fractures.

14 September 2017

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Analysis of the Runx2 promoter in osseous and non-osseous cells and identification of HIF2A as a potent transcription activator.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Vascular endothelial growth factor (VEGF) directly enhances osteoclastic bone resorption and survival of mature osteoclasts

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Transforming growth factor-beta1 modulates the expression of vascular endothelial growth factor by osteoblasts

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Does adult fracture repair recapitulate embryonic skeletal formation?

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Neurohumoral regulation of blood flow to bones and marrow

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

VEGF producing bone marrow stromal cells (BMSC) enhance vascularization and resorption of a natural coral bone substitute.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Flt-1 tyrosine kinase-deficient homozygous mice result in decreased trabecular bone volume with reduced osteogenic potential.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Vascular endothelial growth factor gene-activated matrix (VEGF165-GAM) enhances osteogenesis and angiogenesis in large segmental bone defects.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Vascular endothelial growth factor (VEGF-A) expression in human mesenchymal stem cells: autocrine and paracrine role on osteoblastic and endothelial differentiation

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Combined angiogenic and osteogenic factor delivery enhances bone marrow stromal cell-driven bone regeneration.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Distinguishing the contributions of the perichondrium, cartilage, and vascular endothelium to skeletal development.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

THE VASCULAR CONTRIBUTION TO OSTEOGENESIS. V. THE VASCULATURE SUPPLYING THE EPIPHYSIAL CARTILAGE IN RACHITIC RATS

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Adenoviral VEGF-A gene transfer induces angiogenesis and promotes bone formation in healing osseous tissues

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Vascular endothelial growth factor principally acts as the main angiogenic factor in the early stage of human osteoblastogenesis

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Molecular aspects of healing in stabilized and non-stabilized fractures

2 September 2018

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A molecular analysis of matrix remodeling and angiogenesis during long bone development

2 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Mouse hypoxia-inducible factor-1alpha is encoded by two different mRNA isoforms: expression from a tissue-specific and a housekeeping-type promoter.

2 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Does diabetes delay fracture healing?

2 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189695

Increase of vascular endothelial growth factor mRNA expression by 1,25-dihydroxyvitamin D3 in human osteoblast-like cells

2 September 2018

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12 December 2020

Angiogenesis in fracture repair

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12 December 2020

Effects of reduced blood supply on bone

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12 December 2020

The vascular contribution to osteogenesis. III. Changes in the growth cartilage caused by experimentally induced ischaemia

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12 December 2020

Vascular endothelial growth factor (VEGF) in cartilage neovascularization and chondrocyte differentiation: auto-paracrine role during endochondral bone formation

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12 December 2020

Endothelin-1 induces vascular endothelial growth factor synthesis in osteoblasts: involvement of p38 mitogen-activated protein kinase

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12 December 2020

Effect of human endothelial cells on human bone marrow stromal cell phenotype: role of VEGF?

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12 December 2020

Vascular proliferation and blood supply during distraction osteogenesis: a scanning electron microscopic observation

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12 December 2020

Cancellous bone remodeling occurs in specialized compartments lined by cells expressing osteoblastic markers

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12 December 2020

[Mechanism of bone lengthening by the Ilizarov technique]

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12 December 2020

Induction of vascular endothelial growth factor by IGF-I in osteoblast-like cells is mediated by the PI3K signaling pathway through the hypoxia-inducible factor-2alpha

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12 December 2020

Vascular endothelial growth factor stimulates chemotactic migration of primary human osteoblasts

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12 December 2020

The distribution of blood flow to the whole skeleton in dogs, rabbits and rats measured with microspheres

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12 December 2020

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

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12 December 2020

10.1007/S00109-009-0477-9

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DOI

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release_dbuwikljrvemfffo4egbmzobwu

20 August 2017

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24 November 2022

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20 August 2017

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