Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology (Q37455968)

20 August 2017

Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology (English)

1 reference

20 August 2017

0 references

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Emma Jones

2

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Ceri A Fielding

Ceri Fielding

10

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Philip R Taylor

Philip R Taylor

8

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Awen Gallimore

Awen M Gallimore

13

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Andrew Godkin

Andrew J Godkin

11

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Simon Jones

Simon A Jones

12

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Sarah N Lauder

1

Sarah N Lauder

1 reference

20 August 2017

3

Kathryn Smart

1 reference

20 August 2017

9

Mathew Clement

1 reference

20 August 2017

4

Anja Bloom

1 reference

20 August 2017

5

Anwen S Williams

1 reference

20 August 2017

James P Hindley

6

1 reference

PMCID

3886386

20 August 2017

Beatrice Ondondo

7

1 reference

PMCID

3886386

20 August 2017

language of work or name

English

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publication date

12 August 2013

1 reference

European Journal of Immunology

20 August 2017

1 reference

20 August 2017

43

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20 August 2017

10

1 reference

20 August 2017

2613-2625

1 reference

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

20 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Serial histopathological examination of the lungs of mice infected with influenza A virus PR8 strain

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

The effects of IL-6 on CD4 T cell responses

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Interleukin-6 is crucial for recall of influenza-specific memory CD4 T cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

CD59a deficiency exacerbates influenza-induced lung inflammation through complement-dependent and -independent mechanisms

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Estimation of potential global pandemic influenza mortality on the basis of vital registry data from the 1918-20 pandemic: a quantitative analysis.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Directing transition from innate to acquired immunity: defining a role for IL-6.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Re-emergence of fatal human influenza A subtype H5N1 disease

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Interleukin 6 plays a key role in the development of antigen-induced arthritis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Lethal tuberculosis in interleukin-6-deficient mutant mice

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia

23 August 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

23 August 2017

https://api.crossref.org/works/10.1002%2FEJI.201243018

Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: correlation with inefficient neutrophilia

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Simple method of estimating severity of pulmonary fibrosis on a numerical scale

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Symptom pathogenesis during acute influenza: interleukin-6 and other cytokine responses

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Sickness behavior in mice deficient in interleukin-6 during turpentine abscess and influenza pneumonitis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Protective role of interleukin 6 in the lipopolysaccharide-galactosamine septic shock model.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Impaired immune and acute-phase responses in interleukin-6-deficient mice.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Essential role of IL-6 in protection against H1N1 influenza virus by promoting neutrophil survival in the lung

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

EGF receptor activation during allergic sensitization affects IL-6-induced T-cell influx to airways in a rat model of asthma.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Severe seasonal influenza in ferrets correlates with reduced interferon and increased IL-6 induction

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Increased and long-term generation of dendritic cells with reduced function from IL-6-deficient bone marrow

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Inhibition of tumor necrosis factor reduces the severity of virus-specific lung immunopathology

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Influenza virus: a novel method to assess viral and neutralizing antibody titers in vitro

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Development of a murine hypothermia model for study of respiratory tract influenza virus infection

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Virus-specific CD8+ T-cell memory determined by clonal burst size

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886386

Inhibition of Th1 Differentiation by IL-6 Is Mediated by SOCS1

2 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FEJI.201243018

IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation

21 January 2018

1 reference

12 December 2020

IL-6 Production by Pulmonary Dendritic Cells Impedes Th1 Immune Responses

1 reference

12 December 2020

The influence of macrophage inflammatory protein-1alpha on protective immunity mediated by antiviral cytotoxic T cells

1 reference

12 December 2020

Gene composition of high-yielding influenza vaccine strains obtained by recombination

1 reference

12 December 2020

Accessory signals in murine cytolytic T cell responses. Dual requirement for IL-1 and IL-6

1 reference

12 December 2020

IL-6 increases primed cell expansion and survival

1 reference

12 December 2020

Identifiers

DOI

10.1002/EJI.201243018

1 reference

20 August 2017

1 reference

20 August 2017

1 reference

PMCID

3886386