p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway (Q37454369)

20 August 2017

p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway (English)

1 reference

20 August 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27901115%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Yizhou Joseph He

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27901115%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

author name string

Patrick L Leslie

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27901115%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Andrey P Tikunov

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27901115%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Nick Fenger

5

1 reference

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6 June 2020

Jeffrey M Macdonald

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27901115%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Yanping Zhang

7

1 reference

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6 June 2020

language of work or name

English

0 references

publication date

30 November 2016

1 reference

20 August 2017

1 reference

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6 June 2020

volume

6

1 reference

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6 June 2020

page(s)

38067

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Creative Commons Attribution 4.0 International

6 June 2020

copyright license

start time

30 November 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/srep38067

0 references

cites work

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Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway

23 August 2017

1 reference

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Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism

23 August 2017

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The glycolytic enzyme PFKFB3/phosphofructokinase regulates autophagy

23 August 2017

1 reference

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Emerging landscape of oncogenic signatures across human cancers

23 August 2017

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Strategies for optimizing the response of cancer and normal tissues to radiation

23 August 2017

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TAp73 enhances the pentose phosphate pathway and supports cell proliferation

23 August 2017

1 reference

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PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli

23 August 2017

1 reference

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p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2

23 August 2017

1 reference

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p53-Inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation

23 August 2017

1 reference

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Nucleotide deficiency promotes genomic instability in early stages of cancer development

23 August 2017

1 reference

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p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

23 August 2017

1 reference

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p53 Research: the past thirty years and the next thirty years.

23 August 2017

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gammaH2AX: a sensitive molecular marker of DNA damage and repair

23 August 2017

1 reference

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Tumour suppression by p53: a role for the DNA damage response?

23 August 2017

1 reference

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Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases

23 August 2017

1 reference

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p53 in health and disease

23 August 2017

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TIGAR, a p53-inducible regulator of glycolysis and apoptosis

23 August 2017

1 reference

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Glycolytic enzymes can modulate cellular life span

23 August 2017

1 reference

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Dehydroepiandrosterone, glucose-6-phosphate dehydrogenase, and longevity

23 August 2017

1 reference

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The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression

23 August 2017

1 reference

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5-Fluorouracil: mechanisms of action and clinical strategies

23 August 2017

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p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene

23 August 2017

1 reference

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p53 Binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice.

23 August 2017

1 reference

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A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

23 August 2017

1 reference

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Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair

23 August 2017

1 reference

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

23 August 2017

1 reference

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Control of liver 6-phosphofructokinase by fructose 2,6-bisphosphate and other effectors

23 August 2017

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Cancer. p53, guardian of the genome

23 August 2017

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

23 August 2017

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Glucose-6-phosphate dehydrogenase deficiency: disadvantages and possible benefits

23 August 2017

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AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5128917

Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption.

6 September 2017

1 reference

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Fructose 2,6-bisphosphate and the control of glycolysis by growth factors, tumor promoters and oncogenes

6 September 2017

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Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis

28 September 2017

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Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5128917

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

26 June 2018

1 reference

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The influence of ribose 5-phosphate availability on purine synthesis of cultured human lymphoblasts and mitogen-stimulated lymphocytes

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5128917

p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5128917

Radiosensitization by 6-aminonicotinamide and 2-deoxy-D-glucose in human cancer cells

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5128917

Human glucose-6-phosphate dehydrogenase (G6PD) gene transforms NIH 3T3 cells and induces tumors in nude mice

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5128917

A common phosphorylation site for cyclic AMP-dependent protein kinase and protein kinase C in human placental 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27901115

12 December 2020

inferred from PubMed ID database lookup

Inhibition of nucleotide excision repair by the cyclin-dependent kinase inhibitor p21

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27901115

12 December 2020

inferred from PubMed ID database lookup

Identifiers

1 reference

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30 July 2022

release_5alk3pw2tndc5isdbyvmehzkcq

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/5alk3pw2tndc5isdbyvmehzkcq

30 July 2022

https://api.fatcat.wiki/v0/release/5alk3pw2tndc5isdbyvmehzkcq

1 reference

30 July 2022

https://api.fatcat.wiki/v0/release/5alk3pw2tndc5isdbyvmehzkcq

1 reference

30 July 2022